DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15812 and klhl40b

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_001334076.1	Gene:	klhl40b / 795319	ZFINID:	ZDB-GENE-060227-1	Length:	618	Species:	Danio rerio

Alignment Length:	379	Identity:	73/379 - (19%)
Similarity:	136/379 - (35%)	Gaps:	91/379 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MGHSSTIMDIQRSLRNDNQHCEVVLASRDGVRVRAHLFVLSTCSELMRNLLVD-VPRGQEATIML 70
            |...:.:.|....|...:...:.||..:| .....|..||:.||...|..... |...::..|:|
Zfish    13 MYQQTLLQDGLYDLLESDMMVDCVLKIKD-KEFPCHRLVLAACSSYFRAFFKSGVEESKQREIVL 76

  Fly    71 PDIRGDLLECMLSFIYMGETSLPSASLPEFLEAINLLGIKSAISFECNPSASPPSVDVENHSLAV 135
            .|:...::..:|.::|....::...::.:.....|:|.|         ||.....|......|::
Zfish    77 EDVEPGVMGIILKYLYTSNINVTEQNVQDIFALSNMLQI---------PSIFTVCVSFLQKRLSL 132

  Fly   136 ESAKSITGLQIAEAELLDDEEEPHPMVSVPATTLAGSQHQPSHSSRSLEYIDVYEPPKITYSIEH 200
            .:..:|..|.:    :||     .|.:::.|...|..:.|  ..:|..|::.: .|.::.
Zfish   133 SNCLAIFRLGL----MLD-----CPRLAISARNFACERFQ--FITRDEEFLQL-TPSELA----- 180

  Fly   201 MDGSSSGNQFILTENTGTFTITQSASSLSK-IEADETGTSGAEVDLGD----DDVDAD-LAEDSE 259
                    ..:.:::....|......:|.| :..|:....|...||.|    ..|..| ..::.|
Zfish   181 --------AVLASDSLNVETEQDVFEALIKWVGHDQENRIGDLPDLLDCIRLRLVPRDYFVKNVE 237

  Fly   260 EHE-----------SQMIDEEFAQADPLMEL----------EAGTEMDDDDDVHDQLVDEEIDDK 303
            :||           .|::.:  |.|..|.||          |.|.:..|:::|      ||.:::
Zfish   238 KHEWLSSNPEITKKLQLVKD--AHAGKLPELKKTKNKKSPSEEGQKKGDEEEV------EEEEEQ 294

  Fly   304 PRKLGGGKTRIRRPISAKAVKRLSDCKPTRIQQFAALKREVKDDINDALDLAAD 357
            ..:|.|               .|:|     ..:|....||:...|||:..:|.|
Zfish   295 EERLPG---------------ILND-----NLRFGMFLRELIFLINDSASVAYD 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	19/93 (20%)
		BTB	35..118	CDD:197585	16/83 (19%)
		HTH_psq	348..392	CDD:283007	5/10 (50%)
		HTH_psq	458..501	CDD:283007
klhl40b	XP_001334076.1	BTB	23..127	CDD:279045	22/113 (19%)
		PHA03098	47..540	CDD:222983	67/344 (19%)
		BACK	135..237	CDD:285009	21/126 (17%)
		KELCH repeat	347..394	CDD:276965
		KELCH repeat	398..444	CDD:276965
		Kelch	410..458	CDD:128874
		KELCH repeat	448..493	CDD:276965
		Kelch	460..506	CDD:128874
		Kelch_1	495..535	CDD:279660
		KELCH repeat	496..535	CDD:276965
		KELCH repeat	543..591	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910