DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15812 and MYNN

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001172047.1	Gene:	MYNN / 55892	HGNCID:	14955	Length:	610	Species:	Homo sapiens

Alignment Length:	331	Identity:	65/331 - (19%)
Similarity:	116/331 - (35%)	Gaps:	134/331 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CEVVLASRDGVRVRAHLFVLSTCSELM---------RNLLVDVPRGQEATIMLPDIRGDLLECML 82
            |.:|:..   .:.:||..||::.||..         .|:.:|..:          ::.|..:.:|
Human    26 CTIVIGE---FQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQ----------VKADGFQKLL 77

  Fly    83 SFIYMGETSLPSASLPEFLEAINLLGIKSAI----------SFECNPSA---------------- 121
            .|||.|..:|.|.::.|..:|.:.|.::..:          :|..|||:
Human    78 EFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQT 142

  Fly   122 -------------SPPSVDV-----ENHSLAVESAKS----------ITG-----------LQIA 147
                         |..|.|:     :..:||.:|:::          .||           |:.|
Human   143 CLLTLRDYNNREKSEVSTDLIQANPKQGALAKKSSQTKKKKKAFNSPKTGQNKTVQYPSDILENA 207

  Fly   148 EAEL-LDDEEEPHPMVSVPATTLAGSQHQPSHSSRSLEYIDVYE---PPK---ITYSIEHMDGSS 205
            ..|| ||..:.|.|:|         .|....:.:..||...|.|   |.:   .|.:::...|.|
Human   208 SVELFLDANKLPTPVV---------EQVAQINDNSELELTSVVENTFPAQDIVHTVTVKRKRGKS 263

  Fly   206 SGNQFILTENTGTFTITQSASSLSKIEADETGTSGAEVDLGDDDVDADLAEDSEEHESQMIDEEF 270
            ..| ..|.|:    :::..||..|..||:.:|                     ||     :|:.:
Human   264 QPN-CALKEH----SMSNIASVKSPYEAENSG---------------------EE-----LDQRY 297

  Fly   271 AQADPL 276
            ::|.|:
Human   298 SKAKPM 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	21/94 (22%)
		BTB	35..118	CDD:197585	20/101 (20%)
		HTH_psq	348..392	CDD:283007
		HTH_psq	458..501	CDD:283007
MYNN	NP_001172047.1	BTB	14..115	CDD:306997	21/101 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..197		5/27 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		1/15 (7%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	65/331 (20%)
		zf-C2H2	304..324	CDD:306579	65/331 (20%)
		zf-H2C2_2	316..341	CDD:316026
		C2H2 Zn finger	332..352	CDD:275368
		zf-H2C2_2	345..369	CDD:316026
		SFP1	<354..438	CDD:227516
		C2H2 Zn finger	360..380	CDD:275368
		C2H2 Zn finger	389..409	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		zf-H2C2_2	430..453	CDD:316026
		SFP1	<439..522	CDD:227516
		C2H2 Zn finger	445..465	CDD:275368
		C2H2 Zn finger	473..493	CDD:275368
		C2H2 Zn finger	501..522	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910