DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15812 and KLHL24

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001336342.1	Gene:	KLHL24 / 54800	HGNCID:	25947	Length:	625	Species:	Homo sapiens

Alignment Length:	183	Identity:	43/183 - (23%)
Similarity:	69/183 - (37%)	Gaps:	37/183 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HSSTIMDIQRSLRNDNQHCEVVLASRDGVRVRAHLFVLSTCSELMRNLLVDVPRGQEATIMLPDI 73
            |:..|:.|....|:.....:|::.. :|.....|..|||.||...|.:..:..|  |:..||.:|
Human    48 HAENILQIFNEFRDSRLFTDVIICV-EGKEFPCHRAVLSACSSYFRAMFCNDHR--ESREMLVEI 109

  Fly    74 RG---DLLECMLSFIYMGETSLPSAS-----------------------LPEFLEAINLLGIK-- 110
            .|   :.:||.|.::|.|:..:.:.:                       |.|.|:..|.|||:
Human   110 NGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRF 174

  Fly   111 ------SAISFECNPSASPPSVDVENHSLAVESAKSITGLQIAEAELLDDEEE 157
                  ..:..:|...|.....||..|...:|..|......|...||:..:||
Human   175 ADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	28/126 (22%)
		BTB	35..118	CDD:197585	26/116 (22%)
		HTH_psq	348..392	CDD:283007
		HTH_psq	458..501	CDD:283007
KLHL24	NP_001336342.1	BTB	62..591	CDD:333434	39/169 (23%)
		KELCH repeat	354..393	CDD:276965
		KELCH repeat	397..466	CDD:276965
		KELCH repeat	469..514	CDD:276965
		KELCH repeat	517..556	CDD:276965
		KELCH repeat	559..604	CDD:276965
		Kelch	570..616	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910