DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15812 and klhl20

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_005163549.1	Gene:	klhl20 / 406274	ZFINID:	ZDB-GENE-040426-1935	Length:	591	Species:	Danio rerio

Alignment Length:	437	Identity:	78/437 - (17%)
Similarity:	152/437 - (34%)	Gaps:	158/437 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HSSTIMDIQRSLRNDNQHCEVVLASRDGVRVRAHLFVLSTCSELMRNLLV-DVPRGQEATIMLPD 72
            |....:::...||...:.|:|||.. ...::.||..:||.||...|.:.. ::...::..:::.|
Zfish    32 HPRQTLEVINLLRKHRELCDVVLVV-GAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRD 95

  Fly    73 IRGDLLECMLSFIYMG---------ETSLPSASLPEF--------------LEAINLLGIKSAIS 114
            |....:|.::.|.|..         :|.||:|.|.:.              |:..|.|||::.
Zfish    96 IDERAMELLIDFAYTSQVTVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF-- 158

  Fly   115 FECNPSASPPSVDVENHSLAVESAKSITGLQIAE-------AELLDDEEEPHPMVSVPATTLAGS 172
                         .:.|     |.:.:  |:||:       .|:::.||    .:.:||..|...
Zfish   159 -------------ADTH-----SCREL--LRIADKFTQHNFQEVMESEE----FMLLPANQLIDI 199

  Fly   173 QHQPSHSSRSLEYI----------DVYE-PPKITYSIEHMDGSSSGNQFILTENTGTFTITQSAS 226
            ......:.||.|.:          .:.| .|::...::|:.......:|::
Zfish   200 ISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLV-------------- 250

  Fly   227 SLSKIEADETGTSGAEVDLGDDDVDADLAEDSEEHESQMIDEEFAQADPLMELEAGTEMDDDDDV 291
                      ||.|::..:..|:...||.::::.:  .::.:|    .|||:
Zfish   251 ----------GTVGSDPLIKSDEECRDLVDEAKNY--LLLPQE----RPLMQ------------- 286

  Fly   292 HDQLVDEEIDDKPRKLGGGKTRIRRPI-------------SAKAVKRLS--DCKPTRIQQFAALK 341
                             |.:||.|:||             |..|:..:.  |.:....:..|::.
Zfish   287 -----------------GPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS 334

  Fly   342 R-------EVKDDINDALDLAADAVIIEGLSLQKAADRFDISKTVLW 381
            :       .|.||:..|:...      :|.|...:.:|:| .||..|
Zfish   335 KRRCGVGVSVLDDLLYAVGGH------DGSSYLNSVERYD-PKTNQW 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	28/116 (24%)
		BTB	35..118	CDD:197585	22/106 (21%)
		HTH_psq	348..392	CDD:283007	8/34 (24%)
		HTH_psq	458..501	CDD:283007
klhl20	XP_005163549.1	BTB	41..144	CDD:279045	23/103 (22%)
		PHA03098	45..568	CDD:222983	75/424 (18%)
		BACK	152..253	CDD:285009	22/150 (15%)
		Kelch	301..347	CDD:128874	5/45 (11%)
		KELCH repeat	337..381	CDD:276965	11/45 (24%)
		Kelch	348..395	CDD:128874	8/34 (24%)
		KELCH repeat	385..429	CDD:276965
		Kelch	397..442	CDD:128874
		KELCH repeat	432..477	CDD:276965
		Kelch	444..489	CDD:128874
		KELCH repeat	479..522	CDD:276965
		Kelch	491..536	CDD:128874
		KELCH repeat	526..571	CDD:276965
		Kelch	537..581	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910