DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15812 and Klhl40

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001101665.2	Gene:	Klhl40 / 316088	RGDID:	1305368	Length:	621	Species:	Rattus norvegicus

Alignment Length:	339	Identity:	65/339 - (19%)
Similarity:	108/339 - (31%)	Gaps:	103/339 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IQRSLRNDNQH-----CEVVLASRDGVRVRAHLFVLSTCSELMRNLLVDVPRGQEATIMLPDIRG 75
            :|..|::...|     |.|.:..|:   ...|..||:.||...|...:..|.| ...:.|.::..
  Rat    19 LQDGLKDMLDHGKFLDCVVRVGERE---FPCHRLVLAACSPYFRARFLAEPDG-AGELRLEEVSP 79

  Fly    76 DLLECMLSFIYMGETSLPSASLPEFLEAINLLGIKS----AISF--------------------E 116
            |::..:|.::|..|.:|..||:.:...|.:...|.|    .:||                    :
  Rat    80 DVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVFRLGLLLD 144

  Fly   117 CNPSASP---------PSVDVENHSLAVESAKSITGLQIAEAELLDDEEEPHPMVSVPATTLAGS 172
            |...|..         |.|..:|..|.:.:.:.|.   |..::.|:.|:|.....:|.....:|.
  Rat   145 CARLAVAARDFICARFPLVARDNDFLGLSADELIA---IISSDGLNVEKEEAVFEAVMRWASSGD 206

  Fly   173 QHQPSHSSRSLEYID----------------------VYEPPKITYSIEHMDGSSSGNQFILTEN 215
            ....:...|:|..:.                      |...|::...::.:..:..|....|.:
  Rat   207 ADVQAEHQRALPTVFESIRCRLLPRAFLESRVERHPLVRSQPELLRKVQMVKDAHEGRLTTLRK- 270

  Fly   216 TGTFTITQSASSLSKIEADETGTSGAEVDLGDDDVDADLAEDSEEHESQ---------------- 264
                         .|.|..|......|.:.|.:|..   |||.||....
  Rat   271 -------------KKKEKGEQTARTKEANQGTEDTK---AEDDEERVLPGILNDTLRFGMFLQDL 319

  Fly   265 --MIDEEFAQA-DP 275
              ||.||.|.| ||
  Rat   320 IFMISEEGAVAYDP 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	24/101 (24%)
		BTB	35..118	CDD:197585	21/106 (20%)
		HTH_psq	348..392	CDD:283007
		HTH_psq	458..501	CDD:283007
Klhl40	NP_001101665.2	BTB_POZ	6..137	CDD:365784	27/121 (22%)
		PHA03098	47..594	CDD:222983	59/308 (19%)
		KELCH repeat	351..398	CDD:276965
		KELCH repeat	402..448	CDD:276965
		KELCH repeat	452..497	CDD:276965
		KELCH repeat	500..545	CDD:276965
		KELCH repeat	547..594	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910