DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15812 and CG3726

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	114/557 - (20%)
Similarity:	184/557 - (33%)	Gaps:	191/557 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKWMGHSSTIMDIQRSLRNDNQHCEVVLASRDGVRVRAHLFVLSTCSELMRNLLVDVPRGQEATI 68
            |:|..|.|.:..:...|.:....|:|.||. :|..:|||..||..||.....:|.:....::..|
  Fly     8 LRWKYHHSNLQTMFSQLLDRGCFCDVTLAC-EGQLIRAHRVVLCACSTFFDAVLSNYASERDPII 71

  Fly    69 MLPDIRGDLLECMLSFIYMGETSLPSASLPEFLEAINLLGIKSAISFECNPSASPPSVDVENHSL 133
            ::.|:....::|::.|:|.||.::..:|||..|:..:.|.||.
  Fly    72 IMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKG---------------------- 114

  Fly   134 AVESAKSITGLQIAEAELLDDEEEPHPMVSV-----PATTLAGS-------QHQPS--------- 177
                        :||....|||:.|.|.::.     |..:||.|       |||..
  Fly   115 ------------LAEVTWRDDEDGPPPPMAAAEFHSPPRSLAESYAQDLILQHQQQQQQGPAAPP 167

  Fly   178 ---HSSRSL-----EYIDVYEPPKITYSIEHMDGSSSGNQFILTENTGTFTITQSASSLSKIEAD 234
               |||.:|     |.....:..:::..:|.:    .|...::|..||       ||..:.:.:.
  Fly   168 LNLHSSAALLERDRERERERDRERLSPGMEGV----LGRMPVMTPLTG-------ASGSAGVGSV 221

  Fly   235 ETGTS-----GAEVDLG----------DDDVD-------ADLAEDSEEHESQMID--EEFAQADP 275
            ..|||     ..|..||          ||..|       |..|.:.|..:...::  ..|.:..|
  Fly   222 SGGTSLEGVAPVEHFLGPKRKRGRPPLDDAYDVFNVRKLAQYAANLEPAQRAYLETARHFTEEPP 286

  Fly   276 LMELEAG-------------TEMDDDDDVHDQLVDEEIDDKPRKLGGGKTRIRRPISAKAVKRLS 327
            |....|.             ..:........||:..|..|:.:...|.......|..:...|.||
  Fly   287 LAAHAASMASPPAACPPKQRQRLRHQQQQQQQLLQSESSDQEQPAAGQDWSNLEPNGSATPKLLS 351

  Fly   328 DCKPTRIQQFAALKREVKDDINDALDLAADAVIIEGLS-----LQKAADRFDISKTVLWRRVRTN 387
            |..        |.|:|.:..     |.:..||:....|     |:|..:|
  Fly   352 DGD--------ANKQETEGG-----DESLPAVLTTASSSGTKKLEKIGER--------------- 388

  Fly   388 PAYMRNNRERPSLQEAYERLKNGHSLKSISSELQIPMSTLHRHKVRLSAQGRLPNFVSCRKRDNT 452
                   |||      :.:|::...|...|.|.::                            :.
  Fly   389 -------RER------HGKLRHARRLYEKSGEDEV----------------------------DP 412

  Fly   453 PKDELRDKLAKAVHACLNEGMSQNHAANLFEIPKSTL 489
            ||:| .|:|.:.|....||.:..|.|    |.|:.|:
  Fly   413 PKEE-PDELPQPVEEIENEHLVANRA----ESPRPTV 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	28/92 (30%)
		BTB	35..118	CDD:197585	23/82 (28%)
		HTH_psq	348..392	CDD:283007	7/48 (15%)
		HTH_psq	458..501	CDD:283007	10/32 (31%)
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	29/131 (22%)
		BTB	32..121	CDD:197585	28/123 (23%)
		HTH_psq	587..622	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020