DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15812 and Nacc2

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001094003.1	Gene:	Nacc2 / 296583	RGDID:	1309292	Length:	585	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	95/512 - (18%)
Similarity:	172/512 - (33%)	Gaps:	159/512 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNHLKWMGHSSTIMDIQRSLRNDNQHCEVVLASRDGVRVRAHLFVLSTCSELMRNLLVDVPRGQE 65
            |.|::.....:|::......|....:|:|.:..: |...:||..||:..|...|:|.   ....:
  Rat     4 MLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVK-GQAFKAHRAVLAASSLYFRDLF---SGNSK 64

  Fly    66 ATIMLP-DIRGDLLECMLSFIYMGETSLPSAS------LPEFLEAINLLGIKSAISFE------- 116
            :...|| .:.....:.:|||.|.|:.::.::.      ...||:..:::...:.:.|:
  Rat    65 SAFELPGTVPPACFQQILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCD 129

  Fly   117 ----------------CN---PS----ASPPSVD------VENHSLAVESAKSITGLQIAEAELL 152
                            ||   |:    |:.|||.      |::.::.:..|   ||..:|....|
  Rat   130 SQTAMIEDASSEPQSPCNQLQPATAAYATSPSVPIPLLTRVKHEAMEMPPA---TGPGLASKRPL 191

  Fly   153 DDEEEPHPMVSVPATTLAGSQHQPSHSSRSLEYIDVYEPPKITYSIEHMDGSSSGNQFILTENTG 217
            |  ..|...|:| ||..||:   |..:...|..:..|..|.:.
  Rat   192 D--TGPRDGVAV-ATGAAGT---PGTAPLKLPRVSYYGVPSLA---------------------- 228

  Fly   218 TFTITQSASSLSKIEADETGTSGAEVDLGDDDVDADLAEDSEEHESQMIDEEFAQADPLMELEAG 282
              |:..|...:...:.:.|....:.:...|        ..:..|
  Rat   229 --TLIPSIQQVPYPQGERTSPGASSLPTTD--------SPTSYH--------------------- 262

  Fly   283 TEMDDDDDVHDQLVDEE-------------IDDKPRKL---GGGKTRIRRPISAKAVKRLSD--- 328
            .|.:|||:.:|.:|:|:             :.:||..:   ......|||.:.|.....:|.
  Rat   263 NEDEDDDEAYDTMVEEQYGQMYIKATGNYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGY 327

  Fly   329 -CKPTRIQQFAALKREVKDDINDALDL-AADAVIIEGLSLQKAADRFDISKTVLWRRVRTNPAYM 391
             |.|         |...:.|..:.|:| |...|.|....|........:...||.||:
  Rat   328 RCHP---------KLYSEGDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKVLLRRL------- 376

  Fly   392 RNNRERPSLQEAYER--LKN--GHSLKSISSE-LQIPMSTLHRHKVRLSAQGRLPNF 443
                    |...::|  |.|  |..::|.:|: .:.|:.:...:.|:|..|...|:|
  Rat   377 --------LATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLYCQNFAPSF 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	20/99 (20%)
		BTB	35..118	CDD:197585	18/112 (16%)
		HTH_psq	348..392	CDD:283007	10/44 (23%)
		HTH_psq	458..501	CDD:283007
Nacc2	NP_001094003.1	BTB_POZ_BTBD14A_NAC2	1..131	CDD:349598	24/130 (18%)
		PHA03247	<138..260	CDD:223021	29/162 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..269		5/59 (8%)
		BEN	370..447	CDD:214981	17/71 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910