DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15812 and AgaP_AGAP005748

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_315761.4	Gene:	AgaP_AGAP005748 / 1276418	VectorBaseID:	AGAP005748	Length:	1265	Species:	Anopheles gambiae

Alignment Length:	551	Identity:	101/551 - (18%)
Similarity:	194/551 - (35%)	Gaps:	127/551 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HLKWMGHSSTIMDIQRSLRNDNQHCEVVLA---SRDGVRVRAHLFVLSTCSELMRNL---LVDVP 61
            |||...:...:.:...:|..::::.:|:|.   ..|.:.:.||..||.|.|....|:   :..||
Mosquito   210 HLKQSAYQPNLNNSLTNLCKNDRYADVMLLVCNDDDNIAIPAHRLVLGTFSPYFANVFEKVAFVP 274

  Fly    62 RGQEATIML---PDIRGDLLECMLSFIYMGETSLPSASLP------EFLEAINLLGIKSA--ISF 115
              ..|||.:   |.:....|:|:|.::|.||..:.:.|..      |||......|.:|:  :..
Mosquito   275 --SSATIYVALPPTVTRAALQCLLQYMYTGEAIVHADSFDDVMMCGEFLRINGFAGKRSSGMLKG 337

  Fly   116 ECNPSASPPSVDV-ENHSLAVESAKSITGLQIAEAELLDDEEEPHPMVSVPATTLA--GSQHQPS 177
            :.....|.|.|.| :..::....|:..:....|.|........|.|   ||.|..|  ||...|.
Mosquito   338 QQEELVSVPLVTVTKTINMDAGDARRGSPATPAPANTTTRASTPTP---VPMTMRAYYGSPSPPR 399

  Fly   178 HSSRSLEYID--VYEPPKITYSIEHMDGSSSGNQFILTENTGTFTITQSASSLSKIEADETGTSG 240
            ..:|..|...  |::.|:  |::.|                      |....|..::..:.
Mosquito   400 KIARHYEPAPPAVFQQPR--YTLAH----------------------QPKQDLQSMQQQQQ---- 436

  Fly   241 AEVDLGDDDVDADLAEDSE--EHESQMIDEEFAQADPLMELEAGTEMDDDDDVHDQLVDEEIDDK 303
               .|.......|:.|.:.  .|.|||:.:...|          ...........||...:..:.
Mosquito   437 ---SLRQPMYQEDMLEPTALMGHRSQMLPQRQTQ----------YVQQQQQQQQQQLQQYQPQEM 488

  Fly   304 PRKLGGGKTRIRRPISAKAVKRLSDCKPTRIQQFAALKREVKDDINDALDLAADAVIIEGLSLQK 368
            |..|.....|.::|:.....:.|.       |::..|:   ..|:|    |..:.:::....:|.
Mosquito   489 PDGLFQQPFRQQQPLMMPLRQPLQ-------QRYHPLQ---PLDMN----LGQEDMLLPSQPVQS 539

  Fly   369 AADRFDISKTVL---WRRVRTNPAYMRNN-------------RERPSLQEAYERLKNGHSL---- 413
            |..:..:.:..|   |::::.....:::.             |:.|:||:..::.::..||
Mosquito   540 AQRQQQMMRMQLHRQWQQLQAQAQQLQDELMDPGQDLQPPLVRQPPTLQQTVQKQQSLQSLPQQQ 604

  Fly   414 -----------------KSISSELQIPM---STLHRHKVRLSAQGRLPNFVSCRKRDNTPKDELR 458
                             |.:..:..:|:   :.|...::.|..|.:.|.....::....|:...:
Mosquito   605 SVQQQPRQLQTQQQQQQKEVQQQQSVPIQQPAPLEPPELPLPQQPQCPTVAQAQQPAAPPQPPAQ 669

  Fly   459 DKLAKAVHACLNEGMSQNHAANLFEIPKSTL 489
            .|..:||...   ..|.:.|.:.|:.|:..|
Mosquito   670 QKQPQAVPTV---QQSLDAAQDDFQQPEELL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	29/109 (27%)
		BTB	35..118	CDD:197585	26/96 (27%)
		HTH_psq	348..392	CDD:283007	6/46 (13%)
		HTH_psq	458..501	CDD:283007	8/32 (25%)
AgaP_AGAP005748	XP_315761.4	Myb_DNA-bind_4	10..93	CDD:290549
		BTB	229..325	CDD:279045	26/97 (27%)
		BTB	235..325	CDD:197585	26/91 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920