DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15812 and AgaP_AGAP011142

DIOPT Version :9

Sequence 1:	NP_523897.2	Gene:	CG15812 / 38379	FlyBaseID:	FBgn0035405	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_309506.4	Gene:	AgaP_AGAP011142 / 1270785	VectorBaseID:	AGAP011142	Length:	610	Species:	Anopheles gambiae

Alignment Length:	551	Identity:	112/551 - (20%)
Similarity:	186/551 - (33%)	Gaps:	167/551 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HSSTIMDIQRSLRNDNQHCEVVLASRDGVRVRAHLFVL-STCSELMRNLLVDVPRGQEATIMLPD 72
            ||.::.:|:|.    .:.|:|.| ..|.....||..|| :|..........::...:...|.:.:
Mosquito    59 HSPSMKEIRRM----GKLCDVTL-KVDSHSFSAHRIVLAATIPYFYAMFTHNMAESRIKEITMKE 118

  Fly    73 IRGDLLECMLSFIYMG---------ETSLPSAS---LPEFLEAI-----------NLLGIKS-AI 113
            |....||.:::|.|.|         ::.:..||   |.|..:|.           |:|||:. |.
Mosquito   119 IEPMALESLINFAYSGLVKIDTQNVQSLMVGASFLQLNEVRDACAKFLKRKFHPQNVLGIRQFAD 183

  Fly   114 SFECNPSASPPSVDVENHSLAVESAKSITGLQIAEAELLD------------------------D 154
            :..|:.........:..|...|.:......|  :.:||:|                        .
Mosquito   184 TLGCSKLIVSADRYIHQHFSKVAAGDEFVAL--SYSELIDVIGRDELNVKSEECIFEACMRWVKH 246

  Fly   155 EEEPH-------------PMVSVP--ATTLAGSQ-HQPSHSSRSL--EYIDVYEPPKITYSIEHM 201
            |:|..             |::|..  |.::|..: .:.||..|.|  |..|.:..|:....:...
Mosquito   247 EQETRSEYLPLILANIRLPLLSPQFLADSVATEELIKTSHKCRDLLDEARDFHLMPERRALVSTT 311

  Fly   202 DGSSSGNQFILTENTGTFTITQSASSLSKIEADETGTSGAEVDLGDDDVDADLAEDSEEHESQMI 266
            ........|::........:|::..|:|.:|.....|.  |..:|:              ...|:
Mosquito   312 RTRPRCFDFVVGLIFAVGGLTKNGESVSTVEIYNPATK--EWSMGE--------------AMTML 360

  Fly   267 DEEFAQADPLMELEA-----GTEMDDDDDVHDQLVDEEIDDKPRK---LGGGKTRIRRPISAKAV 323
            ......|....:|.|     |||.....:::|          |||   ..|...|.:|  ||..|
Mosquito   361 RSRVGVAVTNGKLYAFGGFNGTERLSTVEIYD----------PRKHRWSQGTAMRCKR--SAVGV 413

  Fly   324 KRLSD--------------------CKPTRIQQFAALKREVKDDINDALDLAADAVII------E 362
            ..|.|                    |..|  ..::.:...:|  ...|..:||....:      :
Mosquito   414 AALEDYVYVCGGYDGVTSLSTVERYCPKT--DGWSTVAPMMK--YRSAGGVAALGGYVYALGGHD 474

  Fly   363 GLSLQKAADRFD-ISKT------VLWRRVRTNPAYMRN----------NRERPSLQEAYERLKNG 410
            |||:....:|:| .|.|      :|.||.|...|.:.|          |....|: |.|:.:||.
Mosquito   475 GLSIFDTVERYDPFSDTWTKVVSMLNRRCRLGVATLGNKLYACGGYDGNSFLRSV-EVYDPVKNS 538

  Fly   411 HSLKSISSELQIPMSTLHRHKVRLSA-QGRL 440
            .||.:       ||: :.|.:|.|:| .|:|
Mosquito   539 WSLIA-------PMN-VKRSRVALAANMGKL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15812	NP_523897.2	BTB	20..113	CDD:279045	25/117 (21%)
		BTB	35..118	CDD:197585	23/107 (21%)
		HTH_psq	348..392	CDD:283007	15/56 (27%)
		HTH_psq	458..501	CDD:283007
AgaP_AGAP011142	XP_309506.4	BTB	63..167	CDD:279045	23/108 (21%)
		PHA03098	70..541	CDD:222983	98/506 (19%)
		BACK	175..277	CDD:285009	16/103 (16%)
		Kelch	324..371	CDD:128874	9/62 (15%)
		KELCH repeat	361..404	CDD:276965	11/52 (21%)
		Kelch	372..418	CDD:128874	16/57 (28%)
		Kelch_1	408..452	CDD:279660	8/47 (17%)
		KELCH repeat	408..451	CDD:276965	8/46 (17%)
		KELCH repeat	455..498	CDD:276965	10/42 (24%)
		Kelch	467..512	CDD:128874	12/44 (27%)
		Kelch_1	501..546	CDD:279660	14/52 (27%)
		KELCH repeat	502..546	CDD:276965	13/51 (25%)
		Kelch_1	549..593	CDD:279660	6/13 (46%)
		KELCH repeat	549..593	CDD:276965	6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910