DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-30 and NDUFS3

DIOPT Version :9

Sequence 1:	NP_647775.1	Gene:	ND-30 / 38378	FlyBaseID:	FBgn0266582	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_004542.1	Gene:	NDUFS3 / 4722	HGNCID:	7710	Length:	264	Species:	Homo sapiens

Alignment Length:	265	Identity:	171/265 - (64%)
Similarity:	201/265 - (75%)	Gaps:	15/265 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ARAAVAALSAKHVVPAAGSTALRMASTTPV--------EPKKAD-KPTVRQPDAVARSHLSDFGR 65
            |.||||.|..:.::   |::||...:..|.        |...|| :||||..:.||...||.||.
Human     2 AAAAVARLWWRGIL---GASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSAFGE 63

  Fly    66 YVAECLPKYVQKVQLTAGDELEVLIAPEGVVPVLQFLKDHHQAQFTNLVDIAGVDVPCRKNRFEV 130
            ||||.||||||:||::..:||||.|.|:||:|||.||:||..|||.:|||:..||||.|:||||:
Human    64 YVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVPTRQNRFEI 128

  Fly   131 VYNLLSLRYNSRIRVKTYTDELTPLDSACEVHKAANWYEREIWDMYGVFFANHPDLRRILTDYGF 195
            ||||||||:|||||||||||||||::||..|.|||||||||||||:|||||||||||||||||||
Human   129 VYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFANHPDLRRILTDYGF 193

  Fly   196 EGHPQRRDFPLSGYVELRYDDEKKRVVCEPLELAQEFRKFDLSAPWEQFPNFRNANPPAEVVPPQ 260
            ||||.|:|||||||||||||||.||||.||:|||||||||||::|||.||.:|.   |.|.:..:
Human   194 EGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWEAFPVYRQ---PPESLKLE 255

  Fly   261 APAKK 265
            |..||
Human   256 AGDKK 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-30	NP_647775.1	PRK06074	60..242	CDD:235691	142/181 (78%)
NDUFS3	NP_004542.1	PRK06074	58..240	CDD:235691	142/181 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160136
Domainoid	1	1.000	210	1.000	Domainoid score	I2837
eggNOG	1	0.900	-	-		E1_COG0852
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3346
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2499
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51846
OrthoDB	1	1.010	-	-		D1276923at2759
OrthoFinder	1	1.000	-	-		FOG0005716
OrthoInspector	1	1.000	-	-		oto91029
orthoMCL	1	0.900	-	-		OOG6_101398
Panther	1	1.100	-	-	LDO	PTHR10884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3435
SonicParanoid	1	1.000	-	-		X4118
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800