DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BtbVII and BTBD18

DIOPT Version :9

Sequence 1:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001138573.1	Gene:	BTBD18 / 643376	HGNCID:	37214	Length:	712	Species:	Homo sapiens

Alignment Length:	841	Identity:	155/841 - (18%)
Similarity:	255/841 - (30%)	Gaps:	316/841 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PNFISVCSSLLH----NGTLVDVTLAAEGRQLQAHKIVLSACSSYF-QALFTTNPCQHPIVILK- 73
            |.|:.:....||    :....||.|.|||..:.||..:|||||.:| :.|....|.|...|:|:
Human    14 PRFLRLAFLQLHHQQQSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLEL 78

  Fly    74 -DVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLAEMPTDPANLTKSDSKSSTDGTE 137
             .::...|:.:|||:|..|:.||||:...:|..|..|::..|..:..:...|.|:..
Human    79 GGLKISTLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQ-------- 135

  Fly   138 MVGGAGVGTGAGNSAGSLGAGSGSSVGDSLWSSSEAQQFQQQQQQQAQQQAQQQHHHHQQQQQLQ 202
                     |...:...|...|.:.:...:.:.|
Human   136 ---------GRRLNRECLQPTSAAPISARVVTPS------------------------------- 160

  Fly   203 QQQQQAQQQQQQQQHHHHHHQQQQSGQAQAAQTHHHQMRRTPSPLSAGTSPATRRKRLRKSSNNG 267
                            ||.|....:.|             ||.||.     |.|.|.|.|.....
Human   161 ----------------HHPHTPLPTNQ-------------TPCPLG-----AIRLKSLGKEEGPQ 191

  Fly   268 SGDRNNAEEQHNSSLDAGSGAGNAGLSLAQMNQMTFGAGGGLAGHSLHAAKLL-------KESAS 325
            ..:|.||:                                .|:|..|...|..       |.|:.
Human   192 ENNRQNAD--------------------------------NLSGTLLLKRKARACPTPQEKNSSP 224

  Fly   326 AELEQQPQDSDLDDGHGHLHM---QIKPEVD---------------IGGVNQTMPLDISGGT--- 369
            :...|:|:::..|.......:   .:.|.||               ..|:..:.|..|..|:
Human   225 SSHSQEPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSGSSSV 289

  Fly   370 --TPS----EHDAPNSQSSHSEPSPAHAPHPPHPPLGAASSSSG---GSGSFERSFSI------- 418
              ||.    ...:.|.::...:|.|..|     .||.:..:.||   ..||.:||..:
Human   290 PATPGRRLWRQRSVNKETPEDKPKPGRA-----SPLQSTPNPSGLGKTGGSRKRSPEVRAPNSDS 349

  Fly   419 ---GGVGSVE--------C-------------------DPDGTPSSPAVMGTKRNRVLTRQPRVK 453
               |.||.|:        |                   ||.|....|:  ||        ||...
Human   350 AEEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPDPGGDFQEPS--GT--------QPFSS 404

  Fly   454 RDSDSISSTNQISPDTAATTLDFDPFNAAGATSATARDYSTTGSHHLHHQSAVHHHHHLLTVPPR 518
            .:.:...:..::..|:...|              ..:|...:.||...|.
Human   405 NEQEMSPTRTELCQDSPMCT--------------KLQDILVSASHSPDHP--------------- 440

  Fly   519 IERHASEPAPSLAPSTPHLLSVPSSTPY-----LIKQHSDPLLPRQSALHMAGSGSGSSSA---- 574
            :.:...|.:|.|....| :|::....||     |::|      |.::..:...|.:.:|..
Human   441 VVKSEFESSPELVEKEP-MLAIDCREPYAFDTALLEQ------PCEAEEYRITSAAATSELEEIL 498

  Fly   575 --MATGSNPFAPLHRQYSHPLSGSNASYVTPAPLHHPHHISLPESIYASG--------------- 622
              |..||:...|:....|....|..    ||.     :|::.....:..|
Human   499 DFMLCGSDIEPPIGSLESPGAEGCR----TPT-----YHLTETGKNWIEGEEWCLPDMELWPREL 554

  Fly   623 ---SPPPAGSSQYLVPTRVVACPVVSSETAA--------TP----TNASP-----------GSSS 661
               ...|||.::  .||.:::..|:.||.:.        ||    |::.|           .|..
Human   555 TELEKEPAGENR--GPTELLSPLVMPSEVSEVLSVGGRWTPDLEITSSQPLDGQEDKLLHVSSLD 617

  Fly   662 TVSAAVSVVTSP-----NAGLQNSASRHP-LSPTFSIGSDVA-HERRSPHSPSISRSQVVE 715
            |...:...::.|     ..||:.|.:... |.|:...|.:|: |.......|:.|..:.::
Human   618 TPQRSYGDLSPPCSNWVETGLEVSLTTDELLYPSPKAGKEVSGHSELLGSLPASSEEEEID 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	35/99 (35%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	33/87 (38%)
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	34/95 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		7/78 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..355		27/147 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..410		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..676		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910