DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BtbVII and CG6118

DIOPT Version :9

Sequence 1:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001097806.1	Gene:	CG6118 / 41884	FlyBaseID:	FBgn0038339	Length:	967	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	140/594 - (23%)
Similarity:	217/594 - (36%)	Gaps:	167/594 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVQQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQ 66
            ::.|:.|.|||...|......||..:..:||||:||.|:..:|||:|||.||.|||.:|..||..
  Fly   389 TIDQYLLSWNNFHGNMCRGFHSLQKDEKMVDVTIAAGGKIFKAHKLVLSVCSPYFQQIFLENPSS 453

  Fly    67 HPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGL---AEMPTDPANLTKSD 128
            |||:::.||:...:..::||||.|:|||..|.||..||.||.:|||||   ..:.:|.::::
  Fly   454 HPILLMADVEASHMAGLLDFMYSGQVNVKYEDLPVFLKVAEAMKIKGLHTEKNLDSDASDIS--- 515

  Fly   129 SKSSTDGTEM---VGGAGVGTGAGNSAGSLGAGSGSSVGDSLWSSSEAQQFQQQQQQQAQQQAQQ 190
            |...:||||.   .|...|...:|::||..||.|
  Fly   516 SPHESDGTECRYERGTHSVNITSGHAAGYGGAPS------------------------------- 549

  Fly   191 QHHHHQQQQQLQQQQQQAQQQQQQQQHHHHHHQQQQSGQAQAAQTHHHQMRRTPSPLSAG----- 250
                                             .|||..:.:.    :...|.|:|||:|
  Fly   550 ---------------------------------SQQSSPSPSL----NGPNRCPTPLSSGGSGNP 577

  Fly   251 -------------TSPATRRKRLRKSSNNGSGDRNNAEEQHNSSLDAGSGAGNAGLSLAQMNQMT 302
                         |...|..|.|.:::||     ||:...:|.     .|..|..|:|.:.:..:
  Fly   578 NYAGFREHIKSKATLAETFMKNLNRNNNN-----NNSSNNYNH-----LGGSNGSLNLTEADSNS 632

  Fly   303 FG--------------------AGGGLAGH---SLHAAKLLKESASAELEQQP----QDSDLDDG 340
            |.                    |...:..|   .|...|.|||   .|.::.|    .|..|::.
  Fly   633 FAILQANSKKMLDSARKQHKYLAKRKILMHYNTELGGEKRLKE---MERDRYPSAEQHDDALNNN 694

  Fly   341 HGHLHMQIKPEVDIGGVNQTMPLDISGGT-----TPSEHDAPNSQSSHSEPSPAHAPHPPHPPLG 400
            |.|....|...:....|.||.|.......     ..|.|...||.::.::.|..:.        .
  Fly   695 HSHAQDNIMEPIITTIVPQTPPPSTHNNNFKIRLVESHHLTNNSNNNQNQSSNNNN--------S 751

  Fly   401 AASSSSGGSGSFERSFSI------GGVGSVECDPDGTPSSPAVMGTKRNRVLTRQPRVKRDSDSI 459
            ::|..|....:.|.:.::      .|..:.|..|.....:|.:...||.......|     ::::
  Fly   752 SSSPQSNDCNNDEEALNLVQIPNANGSRNREATPTCATPTPDIQLIKREVKTELSP-----AENL 811

  Fly   460 SSTNQISPDTAATTLD---FDPFNAAGATSAT--ARDYSTTGSHHLHHQSAVHHHHHLLTVPPRI 519
            |:.|....:.|....|   .|..|.:|....|  ..:.|..|..:.:..:.....|.||:.   |
  Fly   812 SNNNGHDDEMAGAGFDRKYDDNNNNSGLDMETDSNNNNSKPGGDNNNGLALALGKHKLLSA---I 873

  Fly   520 ERHASEPAP 528
            .|:..:..|
  Fly   874 NRNIEQDHP 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	47/95 (49%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	45/87 (52%)
CG6118	NP_001097806.1	Myb_DNA-bind_4	20..97	CDD:290549
		BTB	408..508	CDD:279045	48/99 (48%)
		BTB	419..510	CDD:197585	45/90 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020