DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BtbVII and ZBTB9

DIOPT Version :9

Sequence 1:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_689948.1	Gene:	ZBTB9 / 221504	HGNCID:	28323	Length:	473	Species:	Homo sapiens

Alignment Length:	393	Identity:	84/393 - (21%)
Similarity:	133/393 - (33%)	Gaps:	130/393 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NHQPNFISV-----CSSLLHN-------GTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNP 64
            |..|..|.:     .||||.:       |...||:|..:||:|:|||.||:|.|.||
Human    17 NPAPRTIQIEFPQHSSSLLESLNRHRLEGKFCDVSLLVQGRELRAHKAVLAAASPYF-------- 73

  Fly    65 CQHPIVILKD---------VQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKI--------K 112
              |..::|.|         ::.|..:.::..:|.|.:.:..:.||..|..|..|::        :
Human    74 --HDKLLLGDAPRLTLPSVIEADAFEGLLQLIYSGRLRLPLDALPAHLLVASGLQMWQVVDQCSE 136

  Fly   113 GLAEMPTDPANLTKSDSKSSTDGTEMVGGAGVGTGAGNSAGSLGAGSGSSVGDSLWSSSEAQQFQ 177
            .|.|:.|                    .|.|:....|||..:|.:.:.|:.|..:.||    .||
Human   137 ILRELET--------------------SGGGISARGGNSYHALLSTTSSTGGWCIRSS----PFQ 177

  Fly   178 QQQQQQAQQQAQQQHHH------HQQQQQLQQQQQQAQQQQQQQQHHHHHHQQQQSGQAQAAQT- 235
            ...|..|..::......      .:..:.||.|.::.:::::..       ..:..|.|..:||
Human   178 TPVQSSASTESPASTESPVGGEGSELGEVLQIQVEEEEEEEEDD-------DDEDQGSATLSQTP 235

  Fly   236 ---------------HHHQMRRTPSPLSAGTS--------PATRRKRL--------RKSSNNGSG 269
                           |...|..||..|..|.|        ||...|..        .|...:|||
Human   236 QPQRVSGVFPRPHGPHPLPMTATPRKLPEGESAPLELPAPPALPPKIFYIKQEPFEPKEEISGSG 300

  Fly   270 DRNNAEEQHNSSLDAGSGAGNAGLSL---------------------AQMNQMTFGAGG-GLAGH 312
            .:....::.......|...||..|..                     ...|::..|.|| |.||.
Human   301 TQPGGAKEETKVFSGGDTEGNGELGFLLPSGPGPTSGGGGPSWKPVDLHGNEILSGGGGPGGAGQ 365

  Fly   313 SLH 315
            ::|
Human   366 AVH 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	30/116 (26%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	27/101 (27%)
ZBTB9	NP_689948.1	BTB	38..140	CDD:306997	28/111 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..279		19/108 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..376		16/76 (21%)
		C2H2 Zn finger	388..405	CDD:275368
		C2H2 Zn finger	413..433	CDD:275368
		zf-C2H2	413..433	CDD:306579
		C2H2 Zn finger	440..457	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910