DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BtbVII and Btbd18

DIOPT Version :9

Sequence 1:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001138572.1	Gene:	Btbd18 / 100270744	MGIID:	3650217	Length:	723	Species:	Mus musculus

Alignment Length:	761	Identity:	160/761 - (21%)
Similarity:	254/761 - (33%)	Gaps:	188/761 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PNFISVCSSLLH----NGTLVDVTLAAEGRQLQAHKIVLSACSSYF-QALFTTNPCQHPIVILK- 73
            |.|:.|....||    :|...|..|.|||..:.||..:|||||.:| :.|....|.|...|:|:
Mouse    14 PRFLRVAFLQLHHQQQSGVFCDALLQAEGEAVPAHCCILSACSPFFTERLERERPVQGRKVVLEM 78

  Fly    74 -DVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLAEMPTDPANLTKSDS-------- 129
             .::...|:.:|||:|..|:.||||:...:|..|..|::..|..:..:...|.|:..
Mouse    79 GGLKIQTLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELETLQLEGGKLVKAPQGRRLNREC 143

  Fly   130 ----KSSTDGTEMVGGAG---VGTGAGNSAGSLGAGSGSSVGDSLWSSSEAQQFQQQQQQQAQQQ 187
                .::.....:||...   .......:...|||....|:|               :::.|.::
Mouse   144 LQPPAAAPISARVVGPKSRPQTPLPVTQTPSPLGAVRLKSLG---------------EEEGAHKK 193

  Fly   188 AQQQHHHHQQQQQLQQQQQ----QAQQQQQQQQHHHHHHQQQQSG-------------------- 228
            ....:.......||:::.:    |..:.....|.......:...|
Mouse   194 TNLPNADSLSDTQLKKKARVCLTQESRSSPSSQREGPKETKSNPGPTALPSLYPSVDEQLLPRKI 258

  Fly   229 QAQAAQTHHHQMRRTPS-----PLSAGTSPATRRKRLRKSSNNGSG-DRNN-AEEQHNSSLDAGS 286
            :...::...|....|||     |.|..|:|..|..|.|..|....| |:.. .|.:...|....|
Mouse   259 RLSRSKPSPHVYTSTPSSILSGPSSMPTAPGRRLWRQRTVSKEAQGVDKQKPGEVRPLQSTPDPS 323

  Fly   287 GAGNAGLSLAQMNQMTFGAGGGLAGHSLHAAKLLK--ESASAELEQQP-----QD-------SDL 337
            ..|....:..|..::.......:....:...||.|  .....|:.|:|     ||       ||:
Mouse   324 DVGKPAENKKQSPELRAPTSSSVEEGQVGRVKLRKIVNGTCWEVVQEPPLRNTQDSPQILEPSDV 388

  Fly   338 DDGHGHLHMQIKPEVDIGGVN-QTMPLDISGGTTPSEHDAPNS--------QSSHSEPSPAHAPH 393
            ::..|.|         :..|| |.:|..|.     ...|:|.|        .:|||
Mouse   389 EEPSGTL---------LSSVNEQEIPARIQ-----LCQDSPESPRLQDILLSASHS--------- 430

  Fly   394 PPHPPLGAASSSSGGSGSFERSFSIGGVGSVECDPDGTPSSPAVMGTKRNRVLTRQP------RV 452
            |.||.:.:...||......|...:|      :|      ..|....|    .|..||      |:
Mouse   431 PDHPMVKSEFGSSPMLTGKESDLNI------DC------REPYTFDT----TLLGQPCEAEQYRI 479

  Fly   453 KRDSDSISSTNQISP--DTAATTLDFDPFNAAGATSATARDYSTTGSHHLHHQSAVHHHHHLLTV 515
                .|.::|:::..  |......|.:|  ..|:..:...:...|.|:||..............:
Mouse   480 ----TSAAATSELEEIFDFMLCGSDVEP--PVGSLESPGAEGCRTPSYHLSETGKNWIEGEEWCL 538

  Fly   516 P-----PR----IERH-ASEPAPSLAPSTPHLLSVPSSTPYLIKQHSDPLLP-----RQSALHMA 565
            |     ||    :|:. .||....:.|.:|.::...::..:      :||.|     ..|...::
Mouse   539 PDMELWPRDLTGLEKEPVSENKEPVEPFSPLVMRSENTESF------EPLSPLVMPSEVSREELS 597

  Fly   566 GSGSGSSSAMATGSNPF-----APLHRQYSHPLSGSNASYVTPAPLHHPHHISLPESIYA-SGSP 624
            ..||.:.....|.|.|.     ..||...|.|   |..||         :|:|.|.|.:| :|..
Mouse   598 LRGSWTPDLEITSSQPLDGQGEKLLHFDSSDP---SQRSY---------NHLSPPCSDWAETGLE 650

  Fly   625 PPAGSSQYLVPTRVVACPVVSSETAATPTNASPGSSSTVSAAVSVV 670
            ...|....|.|.     |....|.:|.|....|...|:....:.||
Mouse   651 VSLGMDDVLCPV-----PKAVREVSANPEQLDPLPGSSEDEEIDVV 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	35/99 (35%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	32/87 (37%)
Btbd18	NP_001138572.1	BTB_POZ_BTBD18	20..138	CDD:349602	37/117 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		2/25 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..350		25/161 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..394		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..637		10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910