DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp5 and USP13

DIOPT Version :9

Sequence 1:	NP_001246589.1	Gene:	Usp5 / 38375	FlyBaseID:	FBgn0035402	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_003931.2	Gene:	USP13 / 8975	HGNCID:	12611	Length:	863	Species:	Homo sapiens

Alignment Length:	862	Identity:	385/862 - (44%)
Similarity:	547/862 - (63%)	Gaps:	65/862 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EELRKHLSKVNVPCASGAGSPPIYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGN 66
            |.|..|:..:.|| .||   ..:||:||.:|||:|.:..|||||:::||.||..:|..:..|||.
Human    26 ELLVPHMPTIRVP-RSG---DRVYKNECAFSYDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQ 86

  Fly    67 RVFLHIQRVKTIKEGADMEAECAESEAGPERKITRLAIGVEGGYNESDM-AKKYEIKDTYSIVVA 130
            .|::|::|  .::|    :...|...|.|:|:.:::.:.::   .:.|: :..||.:|...:|:.
Human    87 SVYMHLKR--HVRE----KVRGASGGALPKRRNSKIFLDLD---TDDDLNSDDYEYEDEAKLVIF 142

  Fly   131 P-HLDKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADNLQQLDNG 194
            | |.:..||..: |||..||.:.:|:|::.|...|.:.    .||:.|: ..||||:||.|||||
Human   143 PDHYEIALPNIE-ELPALVTIACDAVLSSKSPYRKQDP----DTWENEL-PVSKYANNLTQLDNG 201

  Fly   195 KRIPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVTGFPLAVKLGTITAD 259
            .|||||||:|.:|||..||||||||||::||:.|||.||||.||:||||..|:||||||||||.|
Human   202 VRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSGGNGHALEHYRDMGYPLAVKLGTITPD 266

  Fly   260 GKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESESELQ 324
            | :||:|:.|:|.||||||.:||:||||:|..|..:|..:  .:.||..|:.||..:.||.::|:
Human   267 G-ADVYSFQEEEPVLDPHLAKHLAHFGIDMLHMHGTENGL--QDNDIKLRVSEWEVIQESGTKLK 328

  Fly   325 PVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAKLGT 389
            |:.||||||::|||||||::||||.:|.||:||:.:|| ...|.|...|.||..|||.||.|||.
Human   329 PMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVG-NLPRIFDYSPLDPTQDFNTQMTKLGH 392

  Fly   390 GLQSGKY------SSIAENTLDTDH---STGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLLT 445
            ||.||:|      |.:.|..:..:|   ..||||.|||..|.|:||:||:.:||||.:|:|||:.
Human   393 GLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVN 457

  Fly   446 LLDRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREFQERKK 510
            |::||.....||:|..:||:|:|::|..:.||:|..|.:|..:|||.::.|||.||:..::..::
Human   458 LVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRR 522

  Fly   511 AARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIHV 575
            .|....:.||  ::||.|:|..|||:.|..||.::.|:|:|:.:|:...|.:|.|:.|:.|::.:
Human   523 EAEANRRPLP--ELVRAKIPFSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQI 585

  Fly   576 GKFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPE-------PATEEVKFA----- 628
            .|||.|.||||||.|||:||||.||:::.| |.|||||||.||:       |...:.:..
Human   586 KKFTFGLDWVPKKFDVSIDMPDLLDINHLR-ARGLQPGEEELPDISPPIVIPDDSKDRLMNQLID 649

  Fly   629 ---FDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDISEPFVVPN-NSIGDC 689
               .||:.:.:|..||||.|||::|.|.|.|.|.|.|.||::.|:.:.|.:||..:|. ......
Human   650 PSDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWIIVHMEEPDFAEPLTMPGYGGAASA 714

  Fly   690 AANQFVAN------PESL-AMLMSMGFDERQAVAALKATDGNVERATDWIFSH----ADSIGVED 743
            .|:.|.|:      ||.: |::.||||...||:.||:||:.|:|||.||||||    .||..|.:
Human   715 GASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIE 779

  Fly   744 AAPAANSSAAAASSTPNKTNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIRKKGEWVIFNDSKVA 808
            ....||:: ..:.:.|.....:||.|.|.|.|||||||||...|||:|||:|:|.|||:||.||.
Human   780 MENNANAN-IISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDHKVC 843

  Fly   809 KSQNPPKDLGYLYLYMR 825
            .|:.|||||||:|.|.|
Human   844 ASERPPKDLGYMYFYRR 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_001246589.1	UBP14	24..825	CDD:227532	377/838 (45%)
		zf-UBP	204..278	CDD:280334	51/73 (70%)
		Peptidase_C19B	333..823	CDD:239123	232/525 (44%)
		UBA1_UBP5_like	631..674	CDD:270480	19/42 (45%)
		UBA2_UBP5	696..737	CDD:270569	24/51 (47%)
USP13	NP_003931.2	UBP14	30..861	CDD:227532	383/858 (45%)
		zf-UBP	211..284	CDD:280334	51/73 (70%)
		Peptidase_C19B	337..859	CDD:239123	232/526 (44%)
		UBA1_UBP13	652..700	CDD:270567	21/47 (45%)
		UBA2_UBP5	728..769	CDD:270569	23/40 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I392
eggNOG	1	0.900	-	-		E1_COG5207
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	829	1.000	Inparanoid score	I464
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53559
OrthoDB	1	1.010	-	-		D556111at2759
OrthoFinder	1	1.000	-	-		FOG0002129
OrthoInspector	1	1.000	-	-		otm41290
orthoMCL	1	0.900	-	-		OOG6_101380
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2324
SonicParanoid	1	1.000	-	-		X1410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870