DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp5 and UBP14

DIOPT Version :9

Sequence 1:	NP_001246589.1	Gene:	Usp5 / 38375	FlyBaseID:	FBgn0035402	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_009614.2	Gene:	UBP14 / 852349	SGDID:	S000000262	Length:	781	Species:	Saccharomyces cerevisiae

Alignment Length:	867	Identity:	249/867 - (28%)
Similarity:	397/867 - (45%)	Gaps:	141/867 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSKVNVPCASGAGSPPIYKDECVYSYDNP--------ETPT-GLYVCLHSFLGFGEAY------V 57
            |..||||..       :.||||:|.:::|        .:|. .|.:||:.|......:      |
Yeast     6 LENVNVPAV-------VSKDECIYCFESPYNEPLALNASPKHSLNICLNCFQATCNRHVPLHIRV 63

  Fly    58 REYADKTGNRVFLHIQRVKTIKEGADMEAECAESEAGPERKITRLAIGVEGGYNESDMAKKYEIK 122
            .|||..|.:..:|.|.:|:..|     :....|:....:.|:..:....:..:|.....:::..:
Yeast    64 TEYACDTIHSNYLTIAKVEKPK-----QENVEENNNNKKIKLQVIETSEDDTHNTIWSLQRFNGE 123

  Fly   123 DTYSIVVAPHLDKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADN 187
            :....|::...|.       ::.....:.:|.||.|.|...:.:|    .:|..|: ....:.:|
Yeast   124 NVPRTVLSKSTDS-------DISSTALEKIEKILKAKSQDFEDKK----NSWVLEI-STCPHTEN 176

  Fly   188 LQQLDNGKRIP--PSGW----QCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRV-T 245
            .|       ||  |...    ||..||||.||||.|..|:|.|||:.. |..|:.||::|||. .
Yeast   177 FQ-------IPSKPENTVNLNQCSSCDLTQNLWLCLHCGNIGCGREQI-GIDGHSHALDHYRSNN 233

  Fly   246 GFPLAVKLGTITADGKSDVFSYPEDEMVLDP---HLERHLSHFGINMAAMKKSEKSMVELELDIN 307
            ..|||:|||:::: ...|::.|..|:....|   :|...|..:|||:......||::|:|:::.|
Yeast   234 NHPLAIKLGSLSS-STYDLYCYACDDETRFPDNVNLGSALQIYGINIQEKIADEKTLVQLQVEQN 297

  Fly   308 QRIGEWTALTESESELQPV-AGPGY-TGMRNLGNSCYINSVMQVLF--VIPDFQQRFVGTGAERY 368
            :. .::..:..|..|.:.: |...| .|:.|||||||:|||:|.|.  .:|::...|:|:
Yeast   298 EN-WQFRMVDSSGKEFEKLSASKNYGCGLINLGNSCYLNSVIQSLVNGGVPNWSLDFLGS----- 356

  Fly   369 FKEFPSD---PANDFNIQMAKLGTGLQSGKYSSIAENTLDTDHSTGISPAMFKNIVGKNHPDFST 430
              :||.|   |.|:...|..||...::       .|..|   :..||.|..||..:|:||.:||:
Yeast   357 --KFPLDVVYPDNNLKCQWIKLLNAMK-------CEPEL---YPNGIKPTTFKKCIGQNHQEFSS 409

  Fly   431 KQQQDANDFYLHLLTLLDR-----NSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLP 490
            .:||||.:|...||.|||:     :|....||.|.::|::|||::|....||||:  .|.:..:.
Yeast   410 NRQQDAMEFLTFLLDLLDKKFFSSSSSGIPNPNDLVRFMMEDRLQCNICGKVKYS--YEPTEAIQ 472

  Fly   491 VPLDKATNLDEVREFQERKKAARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSK 555
            :||::.   ||.::..||.||                          :|..:.|| |.......|
Yeast   473 IPLEEN---DEPQDMLERIKA--------------------------YFEGQTIE-FKCANCKEK 507

  Fly   556 TNARKITRLATMPDCLMIHVGKFTLGDDWVPKKLDVSVDMP------DELDLSNWRSAGGLQPGE 614
            ..|.|.....::|..|:::..:..| .:|:|.|....:.:|      |.||:|::.|.|.....|
Yeast   508 VTANKKPGFKSLPQTLILNPIRIRL-QNWIPVKTSNELSLPGLIDRDDMLDVSSYLSQGFDPQTE 571

  Fly   615 EALPEPATEEVKFAFDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDISEPF 679
            ..||:.......|..::..:|:|:.|||...|..||.::|.|...|:|.|||.:|:.|.|:::||
Yeast   572 NLLPDEDENRSSFTPNQCSISQLIEMGFTQNASVRALFNTGNQDAESAMNWLFQHMDDPDLNDPF 636

  Fly   680 VVPNNSIGDCAANQFVANPESLAMLMSMGFDERQAVAALKATDGNVERATDWIFSHADSIGVEDA 744
            |.|.|.   ...::...:..||..::|||.:......||...:|:|.|:.:|:|::.|..|....
Yeast   637 VPPPNV---PKKDKREVDEVSLTSMLSMGLNPNLCRKALILNNGDVNRSVEWVFNNMDDDGTFPE 698

  Fly   745 APAANSSAAAASSTPNKTNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIRK----KGEWVIFNDS 805
            ....|..    ........|...: .|.|.|.|.|.|.|...||||..|||    |.:||::||.
Yeast   699 PEVPNEE----QQQKKDLGYSTAK-PYALTAVICHKGNSVHSGHYVVFIRKLVADKWKWVLYNDE 758

  Fly   806 KV--AKSQNPPKDLGYLYLYMR 825
            |:  |.|....|..||:|.|.|
Yeast   759 KLVAADSIEDMKKNGYIYFYTR 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_001246589.1	UBP14	24..825	CDD:227532	243/849 (29%)
		zf-UBP	204..278	CDD:280334	32/77 (42%)
		Peptidase_C19B	333..823	CDD:239123	157/511 (31%)
		UBA1_UBP5_like	631..674	CDD:270480	17/42 (40%)
		UBA2_UBP5	696..737	CDD:270569	12/40 (30%)
UBP14	NP_009614.2	UBP14	1..781	CDD:227532	249/867 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I534
eggNOG	1	0.900	-	-		E1_COG5207
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I568
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53559
OrthoFinder	1	1.000	-	-		FOG0002129
OrthoInspector	1	1.000	-	-		oto99594
orthoMCL	1	0.900	-	-		OOG6_101380
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2324
SonicParanoid	1	1.000	-	-		X1410
TreeFam	1	0.960	-	-
	13	12.860