Protein Alignment Usp5 and USP5

DIOPT Version :10

• Sequence 1: NP_647773.1
• Gene: Usp5 / 38375
• FlyBaseID: FBgn0035402
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001092006.1
• Gene: USP5 / 8078
• HGNCID: 12628
• Length: 858
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 433/872 - (49%)
• Similarity: 585/872 - (67%)
• Gaps: 71/872 - (8%)

  Fly     2 EELRKHLSKVNVPCASGAGSPPIYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGN 66
            |.|...|..:.||.|...    ::||||.:|:|.||:..|||:|:::|||||:.||..:.:|||.
Human     7 EALLSVLPTIRVPKAGDR----VHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQ 67

  Fly    67 RVFLHIQRVKTIKEGADMEAECAESEAGPERKITRLAIGVEGGYNESDMAKKYEIKDTYSIVVAP 131
            ||:||::|.:..||    |.....:...|.:|.||||||||||::.|:  :|:|:.:...||:.|
Human    68 RVYLHLRRTRRPKE----EDPATGTGDPPRKKPTRLAIGVEGGFDLSE--EKFELDEDVKIVILP 126

  Fly   132 HL-----DKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADNLQQL 191
            ..     |.....|| .:..|||.:|||:|:||||..|.|    :..|||||||.||:|.:|:||
Human   127 DYLEIARDGLGGLPD-IVRDRVTSAVEALLSADSASRKQE----VQAWDGEVRQVSKHAFSLKQL 186

  Fly   192 DNGKRIPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVTGFPLAVKLGTI 256
            ||..||||.||:|.|||:..|||||||||||:|||::|||||||:|||||||.||:|||||||||
Human   187 DNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTI 251

  Fly   257 TADGKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESES 321
            |.|| :||:||.||:|||||.|..|||||||:|..|:|::|:|.|||:|:|||||||..:.||..
Human   252 TPDG-ADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGV 315

  Fly   322 ELQPVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAK 386
            .|:|:.||||||:||||||||:|||:||||.|||||:::|.. .|:.|:..|:||..||:.|:||
Human   316 PLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDK-LEKIFQNAPTDPTQDFSTQVAK 379

  Fly   387 LGTGLQSGKYSSIAENTLDTDH-------STGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLL 444
            ||.||.||:||.....:.|.:.       ..||:|.|||.::||.||:|||.:||||.:|:|||:
Human   380 LGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLI 444

  Fly   445 TLLDRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREFQERK 509
            .:::||.|:..||.:..:||:|::::|||:.||||..|.:|..:||||:|.|.|.:|:.|::|:|
Human   445 NMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKK 509

  Fly   510 KAARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIH 574
            :.|.|....||  ::||.:||..:|||.:..||.::.|:|||:.:|:.|.|.||.|:.||.|:|.
Human   510 RQAEEEKMALP--ELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQ 572

  Fly   575 VGKFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPEPA------------------ 621
            :.|||.|.||||||||||::||:|||:|..|.. |||||||.||:.|
Human   573 IKKFTFGLDWVPKKLDVSIEMPEELDISQLRGT-GLQPGEEELPDIAPPLVTPDEPKGSLGFYGN 636

  Fly   622 TEEVKFA-----------FDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDI 675
            .:|..|.           .||:|:.:|:.||||.:||::|.|:|.|||.|||.||:|.|:.|.|.
Human   637 EDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDF 701

  Fly   676 SEPFVVPNNS-IGDCAANQFVANP---ESLAMLMSMGFDERQAVAALKATDGNVERATDWIFSHA 736
            :.|.::|.:| .|..:|   .|:|   :.:..::||||...||:.||:||:.::|||.||||||.
Human   702 ANPLILPGSSGPGSTSA---AADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHI 763

  Fly   737 DSIGVEDAAPAANSSAAAAS---STPNKTNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIRKKGE 798
            |.:..|.|...:...:||.|   |.|.....|||.|||:|.|||||||||...|||||||:|:|.
Human   764 DDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGR 828

  Fly   799 WVIFNDSKVAKSQNPPKDLGYLYLYMR 825
            |||:||.||..|:.|||||||:|.|.|
Human   829 WVIYNDQKVCASEKPPKDLGYIYFYQR 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_647773.1	zf-UBP_var	11..77	CDD:407678	30/65 (46%)
		zf-UBP	204..278	CDD:460464	57/73 (78%)
		Peptidase_C19B	333..823	CDD:239123	250/532 (47%)
		UBA1_UBP5_like	631..674	CDD:270480	23/42 (55%)
		UBA2_UBP5	696..737	CDD:270569	21/43 (49%)
USP5	NP_001092006.1	zf-UBP_var	16..79	CDD:407678	30/66 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..96		5/25 (20%)
		zf-UBP	199..272	CDD:460464	57/73 (78%)
		Peptidase_C19B	327..854	CDD:239123	250/533 (47%)
		UBA1_UBP5	655..702	CDD:270566	25/46 (54%)
		UBA2_UBP5	723..765	CDD:270569	19/41 (46%)