DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp5 and USP5

DIOPT Version :9

Sequence 1:	NP_001246589.1	Gene:	Usp5 / 38375	FlyBaseID:	FBgn0035402	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001092006.1	Gene:	USP5 / 8078	HGNCID:	12628	Length:	858	Species:	Homo sapiens

Alignment Length:	872	Identity:	433/872 - (49%)
Similarity:	585/872 - (67%)	Gaps:	71/872 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EELRKHLSKVNVPCASGAGSPPIYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGN 66
            |.|...|..:.||.|...    ::||||.:|:|.||:..|||:|:::|||||:.||..:.:|||.
Human     7 EALLSVLPTIRVPKAGDR----VHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQ 67

  Fly    67 RVFLHIQRVKTIKEGADMEAECAESEAGPERKITRLAIGVEGGYNESDMAKKYEIKDTYSIVVAP 131
            ||:||::|.:..||    |.....:...|.:|.||||||||||::.|:  :|:|:.:...||:.|
Human    68 RVYLHLRRTRRPKE----EDPATGTGDPPRKKPTRLAIGVEGGFDLSE--EKFELDEDVKIVILP 126

  Fly   132 HL-----DKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADNLQQL 191
            ..     |.....|| .:..|||.:|||:|:||||..|.|    :..|||||||.||:|.:|:||
Human   127 DYLEIARDGLGGLPD-IVRDRVTSAVEALLSADSASRKQE----VQAWDGEVRQVSKHAFSLKQL 186

  Fly   192 DNGKRIPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVTGFPLAVKLGTI 256
            ||..||||.||:|.|||:..|||||||||||:|||::|||||||:|||||||.||:|||||||||
Human   187 DNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVKLGTI 251

  Fly   257 TADGKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESES 321
            |.|| :||:||.||:|||||.|..|||||||:|..|:|::|:|.|||:|:|||||||..:.||..
Human   252 TPDG-ADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQESGV 315

  Fly   322 ELQPVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAK 386
            .|:|:.||||||:||||||||:|||:||||.|||||:::|.. .|:.|:..|:||..||:.|:||
Human   316 PLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDK-LEKIFQNAPTDPTQDFSTQVAK 379

  Fly   387 LGTGLQSGKYSSIAENTLDTDH-------STGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLL 444
            ||.||.||:||.....:.|.:.       ..||:|.|||.::||.||:|||.:||||.:|:|||:
Human   380 LGHGLLSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLI 444

  Fly   445 TLLDRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREFQERK 509
            .:::||.|:..||.:..:||:|::::|||:.||||..|.:|..:||||:|.|.|.:|:.|::|:|
Human   445 NMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKK 509

  Fly   510 KAARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIH 574
            :.|.|....||  ::||.:||..:|||.:..||.::.|:|||:.:|:.|.|.||.|:.||.|:|.
Human   510 RQAEEEKMALP--ELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDYLVIQ 572

  Fly   575 VGKFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPEPA------------------ 621
            :.|||.|.||||||||||::||:|||:|..|.. |||||||.||:.|
Human   573 IKKFTFGLDWVPKKLDVSIEMPEELDISQLRGT-GLQPGEEELPDIAPPLVTPDEPKGSLGFYGN 636

  Fly   622 TEEVKFA-----------FDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDI 675
            .:|..|.           .||:|:.:|:.||||.:||::|.|:|.|||.|||.||:|.|:.|.|.
Human   637 EDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDF 701

  Fly   676 SEPFVVPNNS-IGDCAANQFVANP---ESLAMLMSMGFDERQAVAALKATDGNVERATDWIFSHA 736
            :.|.::|.:| .|..:|   .|:|   :.:..::||||...||:.||:||:.::|||.||||||.
Human   702 ANPLILPGSSGPGSTSA---AADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHI 763

  Fly   737 DSIGVEDAAPAANSSAAAAS---STPNKTNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIRKKGE 798
            |.:..|.|...:...:||.|   |.|.....|||.|||:|.|||||||||...|||||||:|:|.
Human   764 DDLDAEAAMDISEGRSAADSISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGR 828

  Fly   799 WVIFNDSKVAKSQNPPKDLGYLYLYMR 825
            |||:||.||..|:.|||||||:|.|.|
Human   829 WVIYNDQKVCASEKPPKDLGYIYFYQR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_001246589.1	UBP14	24..825	CDD:227532	426/848 (50%)
		zf-UBP	204..278	CDD:280334	57/73 (78%)
		Peptidase_C19B	333..823	CDD:239123	250/532 (47%)
		UBA1_UBP5_like	631..674	CDD:270480	23/42 (55%)
		UBA2_UBP5	696..737	CDD:270569	21/43 (49%)
USP5	NP_001092006.1	UBP14	18..855	CDD:227532	429/859 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..96		5/25 (20%)
		Substrate binding	221..224		1/2 (50%)
		Peptidase_C19B	327..854	CDD:239123	250/533 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	487	1.000	Domainoid score	I392
eggNOG	1	0.900	-	-		E1_COG5207
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55758
Inparanoid	1	1.050	829	1.000	Inparanoid score	I464
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53559
OrthoDB	1	1.010	-	-		D556111at2759
OrthoFinder	1	1.000	-	-		FOG0002129
OrthoInspector	1	1.000	-	-		otm41290
orthoMCL	1	0.900	-	-		OOG6_101380
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2324
SonicParanoid	1	1.000	-	-		X1410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870