Protein Alignment Usp5 and USP17L25

DIOPT Version :10

• Sequence 1: NP_647773.1
• Gene: Usp5 / 38375
• FlyBaseID: FBgn0035402
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001229255.1
• Gene: USP17L25 / 728373
• HGNCID: 44452
• Length: 530
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 84/522 - (16%)
• Similarity: 146/522 - (27%)
• Gaps: 255/522 - (48%)

  Fly   333 GMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAKLGTGLQSGKYS 397
            |::|:||:||:|:.:|.|...|                               .|...:.|.::|
Human    81 GLQNMGNTCYVNASLQCLTYTP-------------------------------PLANYMLSREHS 114

  Fly   398 SIAENTLDTDHSTGISPAMFKNIVGKNH-------------PDFSTKQQQDANDFYLHLLTLLDR 449
            .....     |...:...|..:|....|             ..|...:|:||::|.:..:
Human   115 QTCHR-----HKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTV----- 169

  Fly   450 NSRNQTNPADALKFLLEDRVECLASHK-VKYNTREEYSFRLPVPLDKATNLDEVREFQERKKAAR 513
                     ||:|      ..||..|| |.:::::             |.|
Human   170 ---------DAMK------KACLPGHKQVDHHSKD-------------TTL-------------- 192

  Fly   514 ETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIHVGKF 578
                                 :.:.||     .::.:.|                .||..|
Human   193 ---------------------IHQIFG-----GYWRSQI----------------KCLHCH---- 211

  Fly   579 TLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPEPATEEVK--------FAFDEAVMS 635
            .:.|.:.| .||:::|:         ::|..:|...|.|.:|  ||:.        .....|..|
Human   212 GISDTFDP-YLDIALDI---------QAAQSVQQALEQLVKP--EELNGENAYHCGVCLQRAPAS 264

  Fly   636 ELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDISEPFVVPNNSIGDCAANQFVAN--- 697
            :.||:            ||.                    ::..::......|...|:...|
Human   265 KTLTL------------HTS--------------------AKVLILVLKRFSDVTGNKIAKNVQY 297

  Fly   698 PESLAMLMSMGFDERQAVAALKATDGNVERATDWIFSHADSIGVEDAAPAANSSAAAASSTPNKT 762
            ||.|.|...|                                                 |.||
Human   298 PECLDMQPYM-------------------------------------------------SQPN-- 311

  Fly   763 NYRDGRGKYRLVAFISHMGTSAQVGHYVCHIR-KKGEWVIFNDSKVAKSQ--NPPKDLGYLYLYM 824
               .|...|.|.|.:.|.|.|...|||..::: ::|:|...:|::|..|.  :......|:..|:
Human   312 ---TGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYI 373

  Fly   825 RE 826
            ::
Human   374 QK 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_647773.1	zf-UBP_var	11..77	CDD:407678
		zf-UBP	204..278	CDD:460464
		Peptidase_C19B	333..823	CDD:239123	83/517 (16%)
		UBA1_UBP5_like	631..674	CDD:270480	6/42 (14%)
		UBA2_UBP5	696..737	CDD:270569	6/43 (14%)
USP17L25	NP_001229255.1	Peptidase_C19E	79..373	CDD:239126	83/518 (16%)
		HABP4_PAI-RBP1	<417..454	CDD:461421