DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp5 and Usp13

DIOPT Version :9

Sequence 1:	NP_001246589.1	Gene:	Usp5 / 38375	FlyBaseID:	FBgn0035402	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_001013042.1	Gene:	Usp13 / 72607	MGIID:	1919857	Length:	858	Species:	Mus musculus

Alignment Length:	862	Identity:	387/862 - (44%)
Similarity:	544/862 - (63%)	Gaps:	68/862 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EELRKHLSKVNVPCASGAGSPPIYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGN 66
            |.|..|:..:.|| .||   ..:||:||.:|||:|.:..|||||:::||.||..:|..:..|||.
Mouse    24 ELLVPHMPTIRVP-RSG---DRVYKNECAFSYDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQ 84

  Fly    67 RVFLHIQRVKTIKEGADMEAECAESEAGPERKITR--LAIGVEGGYNESDMAKKYEIKDTYSIVV 129
            .|::|::|  .::|    :...|...|.|:|:.::  |.:.::...|..|    ||.:|...:|:
Mouse    85 SVYMHLKR--HMRE----KVRGASGGALPKRRNSKIFLDLDMDDDLNSDD----YEYEDEAKLVI 139

  Fly   130 AP-HLDKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADNLQQLDN 193
            .| |.:..||..: |||..||.:.:|:|::.|...|.:.    .||:.|| ..||||:||.||||
Mouse   140 FPDHYEIALPNIE-ELPALVTIACDAVLSSKSPYRKQDP----DTWENEV-PVSKYANNLVQLDN 198

  Fly   194 GKRIPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVTGFPLAVKLGTITA 258
            |.|||||||:|.:|||..||||||||||::||:.|||.||||.||:||||..|:||||||||||.
Mouse   199 GVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSGGNGHALEHYRDMGYPLAVKLGTITP 263

  Fly   259 DGKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESESEL 323
            || :||:|:.|:..|.||||.:||:||||:|...:.:|..:  .:.||..|:.||..:.||.::|
Mouse   264 DG-ADVYSFQEEGPVSDPHLAKHLAHFGIDMLHTQGTENGL--RDNDIKPRVSEWEVIQESGTKL 325

  Fly   324 QPVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAKLG 388
            :|:.||||||::|||||||::||||.:|.||:||:.:|| ...|.|...|.||..|||.||.|||
Mouse   326 KPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVG-NLPRIFDYSPLDPTQDFNTQMTKLG 389

  Fly   389 TGLQSGKY------SSIAENTLDTDH---STGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLL 444
            .||.||:|      |.:.|..:..:|   ..||||.|||..|.|:||:||:.:||||.:|:|||:
Mouse   390 HGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLV 454

  Fly   445 TLLDRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREFQERK 509
            .|::||.....||:|..:||:|:|::|..:.||:|..|.:|..:|||.::.|||.||:..::..:
Mouse   455 NLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELITYELMR 519

  Fly   510 KAARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIH 574
            :.|....:.||  ::||.|:|..|||:.|..|:.::.|:|:|:.:|:...|.:|.|:.|:.|::.
Mouse   520 REAEANRRPLP--ELVRAKIPFSACLQAFAEPDNVDDFWSSALQAKSAGVKTSRFASFPEYLVVQ 582

  Fly   575 VGKFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPE-------PATEEVKFA---- 628
            :.|||.|.||||:|.|||:||||.||:|:.| |.|||||||.||:       |...:.:..
Mouse   583 IKKFTFGLDWVPRKFDVSIDMPDLLDISHLR-ARGLQPGEEELPDISPPIVIPDDSKDRLMNQLI 646

  Fly   629 ----FDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDISEPFVVPNNSIGDC 689
                .||:.:.:|..||||.|||::|.|.|.|:|.|.|.||::.|:.:.|.:||..:|  ..|..
Mouse   647 DPSDIDESSVMQLAEMGFPLEACRKAVYFTGNTGAEVAFNWIIVHMEEPDFAEPLAIP--GYGGA 709

  Fly   690 AANQFVAN------PESL-AMLMSMGFDERQAVAALKATDGNVERATDWIFSH----ADSIGVED 743
            .|:.|.|.      ||.: |::.||||...|||.||:||:.|:|||.||||||    .||..|.:
Mouse   710 GASVFGATGLDNQPPEEIVAIITSMGFQRNQAVQALQATNHNLERALDWIFSHPEFEEDSDFVIE 774

  Fly   744 AAPAANSSAAAASSTPNKTNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIRKKGEWVIFNDSKVA 808
            ....||:: ..:.:.|.....:||.|.|.|.|||||||||...|||||||:|:|.|||:||.||.
Mouse   775 MENNANAN-IVSEAKPEGPRVKDGSGMYELFAFISHMGTSTMSGHYVCHIKKEGRWVIYNDHKVC 838

  Fly   809 KSQNPPKDLGYLYLYMR 825
            .|:.|||||||:|.|.|
Mouse   839 ASERPPKDLGYMYFYRR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_001246589.1	UBP14	24..825	CDD:227532	379/838 (45%)
		zf-UBP	204..278	CDD:280334	49/73 (67%)
		Peptidase_C19B	333..823	CDD:239123	234/524 (45%)
		UBA1_UBP5_like	631..674	CDD:270480	19/42 (45%)
		UBA2_UBP5	696..737	CDD:270569	25/51 (49%)
Usp13	NP_001013042.1	UBP14	28..856	CDD:227532	385/858 (45%)
		zf-UBP	209..282	CDD:280334	49/73 (67%)
		Peptidase_C19B	335..854	CDD:239123	234/525 (45%)
		UBA1_UBP13	650..698	CDD:270567	21/47 (45%)
		UBA2_UBP5	723..764	CDD:270569	24/40 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	488	1.000	Domainoid score	I380
eggNOG	1	0.900	-	-		E1_COG5207
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	829	1.000	Inparanoid score	I457
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53559
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002129
OrthoInspector	1	1.000	-	-		otm43346
orthoMCL	1	0.900	-	-		OOG6_101380
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1410
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830