Protein Alignment Usp5 and Usp13

DIOPT Version :10

• Sequence 1: NP_647773.1
• Gene: Usp5 / 38375
• FlyBaseID: FBgn0035402
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_001013042.1
• Gene: Usp13 / 72607
• MGIID: 1919857
• Length: 858
• Species: Mus musculus
• Alignment Length: 862
• Identity: 387/862 - (44%)
• Similarity: 544/862 - (63%)
• Gaps: 68/862 - (7%)

  Fly     2 EELRKHLSKVNVPCASGAGSPPIYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGN 66
            |.|..|:..:.|| .||   ..:||:||.:|||:|.:..|||||:::||.||..:|..:..|||.
Mouse    24 ELLVPHMPTIRVP-RSG---DRVYKNECAFSYDSPNSEGGLYVCMNTFLAFGREHVERHFRKTGQ 84

  Fly    67 RVFLHIQRVKTIKEGADMEAECAESEAGPERKITR--LAIGVEGGYNESDMAKKYEIKDTYSIVV 129
            .|::|::|  .::|    :...|...|.|:|:.::  |.:.::...|..|    ||.:|...:|:
Mouse    85 SVYMHLKR--HMRE----KVRGASGGALPKRRNSKIFLDLDMDDDLNSDD----YEYEDEAKLVI 139

  Fly   130 AP-HLDKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADNLQQLDN 193
            .| |.:..||..: |||..||.:.:|:|::.|...|.:.    .||:.|| ..||||:||.||||
Mouse   140 FPDHYEIALPNIE-ELPALVTIACDAVLSSKSPYRKQDP----DTWENEV-PVSKYANNLVQLDN 198

  Fly   194 GKRIPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVTGFPLAVKLGTITA 258
            |.|||||||:|.:|||..||||||||||::||:.|||.||||.||:||||..|:||||||||||.
Mouse   199 GVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSGGNGHALEHYRDMGYPLAVKLGTITP 263

  Fly   259 DGKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESESEL 323
            || :||:|:.|:..|.||||.:||:||||:|...:.:|..:  .:.||..|:.||..:.||.::|
Mouse   264 DG-ADVYSFQEEGPVSDPHLAKHLAHFGIDMLHTQGTENGL--RDNDIKPRVSEWEVIQESGTKL 325

  Fly   324 QPVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAKLG 388
            :|:.||||||::|||||||::||||.:|.||:||:.:|| ...|.|...|.||..|||.||.|||
Mouse   326 KPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVG-NLPRIFDYSPLDPTQDFNTQMTKLG 389

  Fly   389 TGLQSGKY------SSIAENTLDTDH---STGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLL 444
            .||.||:|      |.:.|..:..:|   ..||||.|||..|.|:||:||:.:||||.:|:|||:
Mouse   390 HGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLV 454

  Fly   445 TLLDRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREFQERK 509
            .|::||.....||:|..:||:|:|::|..:.||:|..|.:|..:|||.::.|||.||:..::..:
Mouse   455 NLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELITYELMR 519

  Fly   510 KAARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIH 574
            :.|....:.||  ::||.|:|..|||:.|..|:.::.|:|:|:.:|:...|.:|.|:.|:.|::.
Mouse   520 REAEANRRPLP--ELVRAKIPFSACLQAFAEPDNVDDFWSSALQAKSAGVKTSRFASFPEYLVVQ 582

  Fly   575 VGKFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPE-------PATEEVKFA---- 628
            :.|||.|.||||:|.|||:||||.||:|:.| |.|||||||.||:       |...:.:..
Mouse   583 IKKFTFGLDWVPRKFDVSIDMPDLLDISHLR-ARGLQPGEEELPDISPPIVIPDDSKDRLMNQLI 646

  Fly   629 ----FDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDISEPFVVPNNSIGDC 689
                .||:.:.:|..||||.|||::|.|.|.|:|.|.|.||::.|:.:.|.:||..:|  ..|..
Mouse   647 DPSDIDESSVMQLAEMGFPLEACRKAVYFTGNTGAEVAFNWIIVHMEEPDFAEPLAIP--GYGGA 709

  Fly   690 AANQFVAN------PESL-AMLMSMGFDERQAVAALKATDGNVERATDWIFSH----ADSIGVED 743
            .|:.|.|.      ||.: |::.||||...|||.||:||:.|:|||.||||||    .||..|.:
Mouse   710 GASVFGATGLDNQPPEEIVAIITSMGFQRNQAVQALQATNHNLERALDWIFSHPEFEEDSDFVIE 774

  Fly   744 AAPAANSSAAAASSTPNKTNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIRKKGEWVIFNDSKVA 808
            ....||:: ..:.:.|.....:||.|.|.|.|||||||||...|||||||:|:|.|||:||.||.
Mouse   775 MENNANAN-IVSEAKPEGPRVKDGSGMYELFAFISHMGTSTMSGHYVCHIKKEGRWVIYNDHKVC 838

  Fly   809 KSQNPPKDLGYLYLYMR 825
            .|:.|||||||:|.|.|
Mouse   839 ASERPPKDLGYMYFYRR 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_647773.1	zf-UBP_var	11..77	CDD:407678	28/65 (43%)
		zf-UBP	204..278	CDD:460464	49/73 (67%)
		Peptidase_C19B	333..823	CDD:239123	234/524 (45%)
		UBA1_UBP5_like	631..674	CDD:270480	19/42 (45%)
		UBA2_UBP5	696..737	CDD:270569	25/51 (49%)
Usp13	NP_001013042.1	zf-UBP_var	33..96	CDD:407678	28/68 (41%)
		zf-UBP	209..282	CDD:460464	49/73 (67%)
		Peptidase_C19B	335..854	CDD:239123	234/525 (45%)
		UBA1_UBP13	650..698	CDD:270567	21/47 (45%)
		UBA2_UBP5	723..764	CDD:270569	24/40 (60%)