Protein Alignment Usp5 and Usp29

DIOPT Version :10

• Sequence 1: NP_647773.1
• Gene: Usp5 / 38375
• FlyBaseID: FBgn0035402
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: XP_011248964.1
• Gene: Usp29 / 57775
• MGIID: 1888998
• Length: 876
• Species: Mus musculus
• Alignment Length: 862
• Identity: 162/862 - (18%)
• Similarity: 283/862 - (32%)
• Gaps: 280/862 - (32%)

  Fly    81 GADMEAECAESEAGPE------RKITRLAIGVEGGYNESD-MAKKYEIKDTYSIVVAPHLDKKLP 138
            |...||.|......||      ||:........||....: ..:|.:.:.:.|   :..::|.:|
Mouse   138 GEHQEAACGSLNTTPESGTPLSRKMPLSMSNTTGGQKRGEKQGRKRKTEPSSS---SAEVNKDIP 199

  Fly   139 ---YPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADNLQQLDNGKRIPPS 200
               .||.:...|...|       .:...|.|||..:       |:..|               .|
Mouse   200 KENTPDQKKKSRRYYS-------RNRGGKAEKAVTL-------REQEK---------------RS 235

  Fly   201 GWQCEKCDLTNNLWLNLTDGSIM----CGRKFFDGSGGNDHAVEHYRVTGFPLAVKLGTITADGK 261
            .|:.|....:.:......||:|:    |       |...|       |:.|.|.:    ||.:|
Mouse   236 NWKLEPAFNSKSYGRANLDGTILPIATC-------SDDRD-------VSIFGLEI----ITHNG- 281

  Fly   262 SDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESESELQPV 326
              |.|.|      ||:|.:           :|:.
Mouse   282 --VQSLP------DPYLNQ-----------LKRE------------------------------- 296

  Fly   327 AGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPA--NDFNIQMAKLGT 389
                  |..||||:||:||::|.:|.||.|.:..:..|       .|.:..  :|..:.:::|
Mouse   297 ------GFPNLGNTCYMNSILQSVFGIPTFAKDLLTQG-------IPWEKVSYDDLIMPLSQL-- 346

  Fly   390 GLQSGKYSSIAENTLDTDHSTGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLLTLLDRN---- 450
                    .:.::..|.:....:..::.|:| ......||..:|.||::|....|..|..|
Mouse   347 --------LVLKDIRDVEIKGELLTSVKKSI-STVADTFSGNEQNDAHEFLSLCLDQLKLNMEKV 402

  Fly   451 ------SRNQTNPADA------------LKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKAT 497
                  .|..|....|            .:|.|...:.|....:....|  |.|..|.:.|...|
Mouse   403 NAMWDTERRNTCAGSAGTKRFVCPVGANFEFELHSSIICEGCGEATIKT--EVSNYLSIDLHHGT 465

  Fly   498 NLDEVREFQERKKAARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKIT 562
            .                           .|.:.:|...:.||.||.||. ......:|.:..|.|
Mouse   466 K---------------------------THPLSIQKSFDLFFTPEKIEH-NCEKCKNKNSVLKYT 502

  Fly   563 RLATMPDCLMIHVGKFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPEPATEE--V 625
             |..:|..|::|:.::.:..|.:|.|.:..|::...|::|:........|...|...|...:  :
Mouse   503 -LRRLPRVLIVHLKRYQVTTDLLPVKSEQPVEISKYLNISSHCHENRKLPFPLANTSPDVSQGMM 566

  Fly   626 KFAFDEAVMSE----------LLTMGFPPEA----------CKRACYHTKNSGLEAASNWLMEHI 670
            ...|:::::|:          :|.:|...:|          .:.|....:..|||:.|....|.:
Mouse   567 PGIFNQSMLSKKVISESCDPMVLQVGSSVDAEIQSFQIMYEDEDASEEQQQRGLESGSMLEPELV 631

  Fly   671 ADED------------------------ISEPFVVPNNSIGDCAANQFVANPESLAMLMSMGFDE 711
            ..|:                        :.||..:.:..:.:....:...|||         |..
Mouse   632 KTENRILRQKTSLATDSMMGDGYSFLPMLCEPLSIQDPGLAEMGLQEVPENPE---------FKN 687

  Fly   712 RQAVAALKATDGNVERATDWIF-SHADSI-------------GVEDAAPAANSSAAAASSTPNKT 762
            .:.:.....:||........:: :|...|             ..||.....:.|.......|:..
Mouse   688 YEKINIYGKSDGRTNTELSKLYQNHGSRIKGLFLPASLASVSSQEDPEKDLSRSPELQEDDPHSF 752

  Fly   763 NY-----RDGR-----GKYRLVAFISHMGTSAQVGHYVCHIR--KKGEWVIFNDSKVAKSQNPP- 814
            .:     :||.     ..||||:.:||.|:|...||||..:.  :|..|::::|.:|.:|.:|.
Mouse   753 AFGSDDSKDGEMGDDLQNYRLVSVVSHFGSSPNSGHYVSDVYDFQKQAWLLYSDVQVFESSDPSI 817

  Fly   815 ----KDLGYLYLYMREQ 827
                .:.||::.||..:
Mouse   818 QENRLNSGYIFFYMHNE 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_647773.1	zf-UBP_var	11..77	CDD:407678
		zf-UBP	204..278	CDD:460464	18/77 (23%)
		Peptidase_C19B	333..823	CDD:239123	114/590 (19%)
		UBA1_UBP5_like	631..674	CDD:270480	10/62 (16%)
		UBA2_UBP5	696..737	CDD:270569	7/41 (17%)
Usp29	XP_011248964.1	PH_USP37_like	11..116	CDD:270122
		UCH	297..>544	CDD:425685	63/295 (21%)
		COG5533	539..830	CDD:444284	52/299 (17%)
		Peptidase_C19	<770..830	CDD:470612	20/59 (34%)