Protein Alignment Usp5 and Usp5

DIOPT Version :10

• Sequence 1: NP_647773.1
• Gene: Usp5 / 38375
• FlyBaseID: FBgn0035402
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_038728.1
• Gene: Usp5 / 22225
• MGIID: 1347343
• Length: 858
• Species: Mus musculus
• Alignment Length: 876
• Identity: 434/876 - (49%)
• Similarity: 588/876 - (67%)
• Gaps: 79/876 - (9%)

  Fly     2 EELRKHLSKVNVPCASGAGSPPIYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGN 66
            |.|...|..:.||.|...    ::||||.:|:|.||:..|||:|:::|||||:.||..:.:|||.
Mouse     7 EALLSVLPTIRVPKAGDR----VHKDECAFSFDTPESEGGLYICMNTFLGFGKQYVERHFNKTGQ 67

  Fly    67 RVFLHIQRVKTIKEGADMEAECAESEAG----PERKITRLAIGVEGGYNESDMAKKYEIKDTYSI 127
            ||:||::|.:..||        .::.||    |.:|.||||||||||::.::  .|:|..:...|
Mouse    68 RVYLHLRRTRRPKE--------EDTSAGTGDPPRKKPTRLAIGVEGGFDLTE--DKFEFDEDVKI 122

  Fly   128 VVAPHL-----DKKLPYPDPELPMRVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADN 187
            |:.|..     |.....|| .:..|||.:|||:|:||||..|.|    :..|||||||.||:|.|
Mouse   123 VILPDYLEIARDGLGGLPD-IVRDRVTSAVEALLSADSASRKQE----VQAWDGEVRQVSKHAFN 182

  Fly   188 LQQLDNGKRIPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVTGFPLAVK 252
            |:||||..||||.||:|.|||:..|||||||||||:|||::|||||||:|||||||.||:|||||
Mouse   183 LKQLDNPARIPPCGWKCSKCDMRENLWLNLTDGSILCGRRYFDGSGGNNHAVEHYRETGYPLAVK 247

  Fly   253 LGTITADGKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALT 317
            |||||.|| :||:||.||:|||||.|..|||||||:|..|:|::|:|.|||:|:|||||||..:.
Mouse   248 LGTITPDG-ADVYSYDEDDMVLDPSLAEHLSHFGIDMLKMQKTDKTMTELEIDMNQRIGEWELIQ 311

  Fly   318 ESESELQPVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNI 382
            ||...|:|:.||||||:||||||||:|||:||||.|||||:::|.. .|:.|:..|:||..||:.
Mouse   312 ESGVPLKPLFGPGYTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDK-LEKIFQNAPTDPTQDFST 375

  Fly   383 QMAKLGTGLQSGKYSSIAENTLDTDH-------STGISPAMFKNIVGKNHPDFSTKQQQDANDFY 440
            |:||||.||.||:||..|..:.|.:.       ..||:|.|||.::||.||:|||.:||||.:|:
Mouse   376 QVAKLGHGLLSGEYSKPALESGDGEQVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFF 440

  Fly   441 LHLLTLLDRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREF 505
            |||:.:::||.|:..||.:..:||:|::::|||:.||||..|.:|..:||||:|.|.|.:|:.|:
Mouse   441 LHLINMVERNCRSSENPNEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEY 505

  Fly   506 QERKKAARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDC 570
            :|:|:.|.|  :::|..::||.:||..:|||.:..||.::.|:|||:.:|:.|.|.||.|:.||.
Mouse   506 EEKKRQAEE--EKVPLPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFASFPDY 568

  Fly   571 LMIHVGKFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPEPA-------------- 621
            |:|.:.|||.|.||||||||||::||:|||:|..|.. |||||||.||:.|
Mouse   569 LVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGT-GLQPGEEELPDIAPPLVTPDEPKGSLG 632

  Fly   622 ----TEEVKFA-----------FDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIA 671
                .:|..|.           .||:|:.:|:.||||.:||::|.|:|.|||.|||.||:|.|:.
Mouse   633 FYGNEDEDSFCSPHFSSPTSPMLDESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMD 697

  Fly   672 DEDISEPFVVPNNS-IGDCAANQFVANP---ESLAMLMSMGFDERQAVAALKATDGNVERATDWI 732
            |.|.:.|.::|.:| .|..:|   .|:|   :.:..::||||...||:.||:||:.::|||.|||
Mouse   698 DPDFANPLILPGSSGPGSTSA---AADPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWI 759

  Fly   733 FSHADSIGVEDAAPAANSSAAAAS---STPNKTNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIR 794
            |||.|.:..|.|...:...:||.|   |.|.....|||.|||:|.|||||||||...|||||||:
Mouse   760 FSHIDDLDAEAAMDISEGRSAAESISESVPVGPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIK 824

  Fly   795 KKGEWVIFNDSKVAKSQNPPKDLGYLYLYMR 825
            |:|.|||:||.||..|:.|||||||:|.|.|
Mouse   825 KEGRWVIYNDQKVCASEKPPKDLGYIYFYQR 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_647773.1	zf-UBP_var	11..77	CDD:407678	30/65 (46%)
		zf-UBP	204..278	CDD:460464	57/73 (78%)
		Peptidase_C19B	333..823	CDD:239123	250/532 (47%)
		UBA1_UBP5_like	631..674	CDD:270480	23/42 (55%)
		UBA2_UBP5	696..737	CDD:270569	21/43 (49%)
Usp5	NP_038728.1	zf-UBP_var	16..79	CDD:407678	29/62 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..98		6/24 (25%)
		zf-UBP	199..272	CDD:460464	54/72 (75%)
		Peptidase_C19B	327..854	CDD:239123	259/547 (47%)
		UBA1_UBP5	655..702	CDD:270566	20/47 (43%)
		rad23	<699..>794	CDD:273167	46/100 (46%)
		UBA2_UBP5	723..765	CDD:270569	19/44 (43%)