DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp5 and usp-5

DIOPT Version :9

Sequence 1:	NP_001246589.1	Gene:	Usp5 / 38375	FlyBaseID:	FBgn0035402	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_491765.2	Gene:	usp-5 / 172296	WormBaseID:	WBGene00020839	Length:	789	Species:	Caenorhabditis elegans

Alignment Length:	822	Identity:	308/822 - (37%)
Similarity:	450/822 - (54%)	Gaps:	79/822 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGNRVFLHIQRVKTIKEGADMEAEC 88
            |:||:|.|.:.:|....|||:.|.::..|...:...|...:||.:|:..:..|.|.|
Worm    25 IFKDQCAYCFKDPHGKDGLYISLKNYHAFCREHAEIYGTTSGNTLFVQFESTKKIIE-------- 81

  Fly    89 AESEAGPERKITRLAIGVEGGYNESDMAKKYEIKDTYSIVVAPHLDKKLPYPDPELPMRVTQSVE 153
            ..::..|..|:|:|.|         |...|:|.:|.|.:||.|...:::.... .|| .:.:::.
Worm    82 ERTDGEPTSKMTKLTI---------DSDPKFEFEDKYCVVVHPEYSQQVKNVQ-NLP-EIAEAIA 135

  Fly   154 AILAADSAIAKLEKATLMGT----WDGEVRQASKYADNLQQLDNGKRIPPSGWQC--EKCDLTNN 212
            .|....||    |:.:|:.:    ||.|::..:|: .||:|.||||.:..:||.|  |.|.|.:|
Worm   136 QIANTTSA----ERLSLLSSTSNAWDAEIKLITKH-QNLEQQDNGKHLALTGWTCEVEGCGLNDN 195

  Fly   213 LWLNLTDGSIMCGRKFF--DG--SGGNDHAVEHYRVTGFPLAVKLGTITADGK-SDVFSYPEDEM 272
            ||||||||::.|||..|  ||  :.||.|..:::..|.|||.||||||:::.: .||:||.||:.
Worm   196 LWLNLTDGAVRCGRSQFLSDGKKTNGNGHMQDYFDSTRFPLVVKLGTISSNLELIDVYSYDEDDA 260

  Fly   273 VLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESESELQPVAGPGYTGMRNL 337
            |:||:||:||.|||::...|:|:.||.:|:|||:|:: .||:..||....|:|:.||||||:.|.
Worm   261 VIDPNLEKHLKHFGLDPTKMEKTAKSTMEMELDMNEK-WEWSKCTEDGLLLEPIFGPGYTGLVNT 324

  Fly   338 GNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPA-NDFNIQMAKLGTGLQSGKYSSIAE 401
            |:|||:|||:|.|..:..||.|:...|.|. ....|.|.. ||||.|.:|:...:.||.|||..:
Worm   325 GSSCYMNSVLQALVTVDSFQTRYGEQGLET-LVNCPLDKLHNDFNAQFSKVVRAMLSGDYSSEMD 388

  Fly   402 NTLDTDHSTGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLLTLLDRNSRNQT-NPADALKFLL 465
            .|  .:|   |.|..||.:...||.||||.:|||..::...|...:..|||.:. :|.|:.||..
Worm   389 PT--NNH---IKPLQFKRVAAGNHRDFSTSKQQDVEEYIRFLFEKIAENSRTEVIDPTDSFKFKA 448

  Fly   466 EDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREFQERKKAARETGQRLPDRDIVRHKVP 530
            .:|.|...:.:|:|..:||...|||:..|..                    :.:||.: .|:.|.
Worm   449 INRFEDRGTRRVRYTDQEEMLIRLPISGDLL--------------------RPIPDTE-NRYSVD 492

  Fly   531 LQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIHVGKFTLGDDWVPKKLDVSVDM 595
            ::|.:..:|..:.|:.:.|...|....|.....:.|.||.|...|.||....|...||||:.:::
Worm   493 MKAAIHAYFDVQKIDDYISPITGEPKGATNTISMKTFPDYLFFQVSKFAYNVDGTQKKLDMELEI 557

  Fly   596 PDELDLSNWRSAGGLQ-----PGEEALPEPATEEVKFAFDEAVMSELLTMGFPPEACKRACYHTK 655
            .:|||||.:|..|.|:     |.||......|.::. |....|..||:.|||...||.||.|::
Worm   558 EEELDLSGYRGHGKLEHEIALPDEEPTAPRTTPDIP-ASVRFVAGELMLMGFCENACYRAAYYS- 620

  Fly   656 NSGLEAASNWLMEHIADEDISEPFVVPNNSIGDCAANQFVANPESLAMLMSMGFDERQAVAALKA 720
            |..:|.||||||||:.|.||::.||:|:   |..:|...| :|..:|.::.|||...||..|||.
Worm   621 NGNVEIASNWLMEHMDDSDINDLFVIPS---GTPSARGEV-DPNLVASIVEMGFSNHQAKYALKQ 681

  Fly   721 TDGNVERATDWIFSHADSIGVEDAAPAANSSAAAASSTPNKT--NYRDGRGKYRLVAFISHMGTS 783
            .. .|..|.:|:|::.|||.||.||...:|.|...|.|.:.|  .::||..||:|:..|||||:.
Worm   682 VP-TVAEAVEWLFANMDSIPVESAAVGLSSDAPEPSVTESATQKTFKDGGEKYKLIGMISHMGSR 745

  Fly   784 AQVGHYVCHIRKKGEWVIFNDSKVAKSQNPPKDLGYLYLYMR 825
            ...||||.|:.|:|:||:|||.|||.||:|||.|.|:|||.|
Worm   746 PDSGHYVAHMLKEGKWVLFNDEKVALSQDPPKKLAYVYLYKR 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_001246589.1	UBP14	24..825	CDD:227532	307/820 (37%)
		zf-UBP	204..278	CDD:280334	41/80 (51%)
		Peptidase_C19B	333..823	CDD:239123	186/498 (37%)
		UBA1_UBP5_like	631..674	CDD:270480	22/42 (52%)
		UBA2_UBP5	696..737	CDD:270569	14/40 (35%)
usp-5	NP_491765.2	UBP14	19..788	CDD:227532	308/822 (37%)
		zf-UBP	185..266	CDD:280334	41/80 (51%)
		Peptidase_C19B	320..786	CDD:239123	187/499 (37%)
		UBA1_scUBP14_like	597..634	CDD:270482	19/37 (51%)
		UBA_atUPL1_2_like	660..695	CDD:270512	13/35 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I776
eggNOG	1	0.900	-	-		E1_COG5207
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I755
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53559
OrthoDB	1	1.010	-	-		D556111at2759
OrthoFinder	1	1.000	-	-		FOG0002129
OrthoInspector	1	1.000	-	-		oto17846
orthoMCL	1	0.900	-	-		OOG6_101380
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2324
SonicParanoid	1	1.000	-	-		X1410
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.770