Protein Alignment Usp5 and USP20

DIOPT Version :10

• Sequence 1: NP_647773.1
• Gene: Usp5 / 38375
• FlyBaseID: FBgn0035402
• Length: 827
• Species: Drosophila melanogaster
• Sequence 2: NP_006667.3
• Gene: USP20 / 10868
• HGNCID: 12619
• Length: 914
• Species: Homo sapiens
• Alignment Length: 839
• Identity: 162/839 - (19%)
• Similarity: 245/839 - (29%)
• Gaps: 334/839 - (39%)

  Fly   176 GEVRQASKYADNLQQLDNGKRIPPSGWQCEKCDLTN-NLW--LNLTDGSIMCGRKFFDGSGGNDH 237
            |:.|....:.|::.::.....:..|...|:.|.:|. |||  |.:....:.||..|      .||
Human     2 GDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYVGCGESF------ADH 60

  Fly   238 AVEHYRVTGFPLAVKLGTITADGKSDVFSYP-EDEMVLDPHLERHLSHFGINMAAMKKSEKS--- 298
            :..|.:.....|.|.|.|..      ::.|. |.|:.|:..|...|  .|   ::.|.||:.
Human    61 STIHAQAKKHNLTVNLTTFR------LWCYACEKEVFLEQRLAAPL--LG---SSSKFSEQDSPP 114

  Fly   299 ----MVELELDINQRIGEWTALTESESELQPVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQR 359
                :..:.:.:...       .|||||...:...|.|||:|||||||:|:.:|.|...|...|.
Human   115 PSHPLKAVPIAVADE-------GESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPPLTQF 172

  Fly   360 FVGTGAERYFKEFPSDPANDFNIQMAKLGTGLQSGKYSSIAENTLDTDHSTGISPAMFKNIVGKN 424
            |:..|.   .......||      :.|        .|..:..........:.:.|....:.:...
Human   173 FLECGG---LVRTDKKPA------LCK--------SYQKLVSEVWHKKRPSYVVPTSLSHGIKLV 220

  Fly   425 HPDFSTKQQQDANDFYLHLLTLLDRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRL 489
            :|.|....|||..:|   |..|:|:.......|..|...|.|.|.
Human   221 NPMFRGYAQQDTQEF---LRCLMDQLHEELKEPVVATVALTEARD-------------------- 262

  Fly   490 PVPLDKATNLDEVREFQERKKAARETGQRLPDRDIVRHKVPLQACLERFFGPE------------ 542
                ..:::.||.||           |.|.|..|   ..:...:..:|..|..
Human   263 ----SDSSDTDEKRE-----------GDRSPSED---EFLSCDSSSDRGEGDGQGRGGGSSQAET 309

  Fly   543 --LIEQFYSTAIGSK--------------TNARKI-------TRLATMPD--------------- 569
              ||......||..|              ||:.::       |.:|.:.|
Human   310 ELLIPDEAGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMAALDDQPAEAQPPSPRSSSP 374

  Fly   570 ------------------CLMIH--------------VGKFTLGDDWVPKKLDVSVDMPDELDLS 602
                              |..:|              .....:...:|.||..|
Human   375 CRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPRASPVRMAPSYVLKKAQV----------- 428

  Fly   603 NWRSAGGLQPGEE------------------------------------ALPEPATEEVKFAFDE 631
              .|||..:..|:                                    :||.|..|      |.
Human   429 --LSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKE------DL 485

  Fly   632 AVMSELLTMGFP--PEACKRACYHTKNSGLEAASNWL---MEHIADEDISEPFVV---------P 682
            |.:...:....|  |.||         ....||..||   :|:|      ..|||         |
Human   486 AKLHSAIYQNVPAKPGAC---------GDSYAAQGWLAFIVEYI------RRFVVSCTPSWFWGP 535

  Fly   683 NNSIGDCAANQFVAN----------------------------PESLAMLMSMGFDERQAVAALK 719
            ..::.||.|..|.|:                            ||.|.:.:..  ...:.:.:.|
Human   536 VVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKR--FRHEVMYSFK 598

  Fly   720 ATDGNVERATDWIFSHADSIGVE--DAAPAANSSAAAASSTPNKTNYRDGRGKYRLVAFISHMGT 782
                        |.||. |..:|  |..|.......:..:|            |.|::.|.|.||
Human   599 ------------INSHV-SFPLEGLDLRPFLAKECTSQITT------------YDLLSVICHHGT 638

  Fly   783 SAQVGHYVCHIRK--KGEWVIFNDSKVAK-----SQNPPKDLGYLYLY-------MREQ 827
            :.. |||:.:.:.  .|:|..|:|..|.:     .||..   ||:..|       |||:
Human   639 AGS-GHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNAE---GYVLFYRKSSEEAMRER 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_647773.1	zf-UBP_var	11..77	CDD:407678
		zf-UBP	204..278	CDD:460464	21/77 (27%)
		Peptidase_C19B	333..823	CDD:239123	120/658 (18%)
		UBA1_UBP5_like	631..674	CDD:270480	11/47 (23%)
		UBA2_UBP5	696..737	CDD:270569	8/68 (12%)
USP20	NP_006667.3	zf-UBP	30..90	CDD:460464	19/71 (27%)
		UCH	145..682	CDD:425685	121/659 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..347		20/127 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..415		2/54 (4%)
		DUSP	702..785	CDD:197831
		DUSP	810..895	CDD:197831