DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp5 and usp5

DIOPT Version :9

Sequence 1:	NP_001246589.1	Gene:	Usp5 / 38375	FlyBaseID:	FBgn0035402	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	XP_012821494.1	Gene:	usp5 / 100144735	XenbaseID:	XB-GENE-995356	Length:	855	Species:	Xenopus tropicalis

Alignment Length:	875	Identity:	423/875 - (48%)
Similarity:	577/875 - (65%)	Gaps:	87/875 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSKVNVPCASGAGSPPIYKDECVYSYDNPETPTGLYVCLHSFLGFGEAYVREYADKTGNRVFLHI 72
            |..:.:|.|...    ::||||.|::..|||.:|||:|:::|||||..||....:|||.|.|||:
Frog    12 LPTIRLPRAGDR----VHKDECAYTFHTPETDSGLYICMNTFLGFGRPYVERQYNKTGQRAFLHL 72

  Fly    73 QRVKTIKEGADMEAECAESEAG--PERKITRLAIGVEGGYNESDMAKKYEIKDTYSIVVAPHLDK 135
            :|.      |.|::|.:.|..|  |.:|.||||||:|||::.|:...:||  :...:|:.|..
Frog    73 KRT------AKMKSEESNSGTGDPPRKKPTRLAIGMEGGFDMSEEQCEYE--EVVKLVILPEF-- 127

  Fly   136 KLPYPD------PELPM-RVTQSVEAILAADSAIAKLEKATLMGTWDGEVRQASKYADNLQQLDN 193
             |..|.      ||:.. ||:.:::|||:||||..|.|    :..|||||||.||:|.|||||:.
Frog   128 -LEIPRDGLLGLPEMVRDRVSSAIDAILSADSASRKQE----IQAWDGEVRQVSKHAFNLQQLEG 187

  Fly   194 GKRIPPSGWQCEKCDLTNNLWLNLTDGSIMCGRKFFDGSGGNDHAVEHYRVTGFPLAVKLGTITA 258
            ..||||.||:|..|||..|||||:|||:|:|||::|||||||:||::||:.||:||||||||||.
Frog   188 VPRIPPCGWKCSVCDLRENLWLNMTDGAILCGRRYFDGSGGNNHALQHYQETGYPLAVKLGTITP 252

  Fly   259 DGKSDVFSYPEDEMVLDPHLERHLSHFGINMAAMKKSEKSMVELELDINQRIGEWTALTESESEL 323
            || .||:||.||:|||||:|..|||||||:|..|:|::|:|.|||:|:|||||||..:.||..:|
Frog   253 DG-GDVYSYDEDDMVLDPNLAEHLSHFGIDMMKMQKTDKTMTELEIDMNQRIGEWEVIQESGVQL 316

  Fly   324 QPVAGPGYTGMRNLGNSCYINSVMQVLFVIPDFQQRFVGTGAERYFKEFPSDPANDFNIQMAKLG 388
            ||:.|.||||::|||||||:||.|||:|.||.||:::| ...|:.|::.|:||..|||.|:||||
Frog   317 QPLYGSGYTGIQNLGNSCYLNSTMQVIFSIPAFQRKYV-ERMEQIFQKSPADPTQDFNTQVAKLG 380

  Fly   389 TGLQSGKYSSIA---ENTLDTDH---STGISPAMFKNIVGKNHPDFSTKQQQDANDFYLHLLTLL 447
            .|:.||:||..|   :|....:|   ..||:|.|||.:|||.||:|||.:||||.:|:||.:.::
Frog   381 NGMLSGEYSKPAVEKDNDTAPEHKGLQDGIAPRMFKALVGKGHPEFSTNRQQDAQEFFLHFINMV 445

  Fly   448 DRNSRNQTNPADALKFLLEDRVECLASHKVKYNTREEYSFRLPVPLDKATNLDEVREFQE-RKKA 511
            :||.|:.:||.:..:||:|::::||.|.||||..|.||..:||||::.|.|.||:..::: |.:|
Frog   446 ERNCRSSSNPNEVFRFLVEEKIKCLVSQKVKYTQRVEYILQLPVPMEAALNKDELSAYEQCRLQA 510

  Fly   512 ARETGQRLPDRDIVRHKVPLQACLERFFGPELIEQFYSTAIGSKTNARKITRLATMPDCLMIHVG 576
            .||   ..|..::||.::|..:|||.|..||.:::|:|.|:.:|:||.|.:|.|:.||.|:|.:.
Frog   511 ERE---HRPPPELVRARIPFTSCLEAFAAPEQLDEFWSAALQAKSNALKTSRFASFPDYLVIQIK 572

  Fly   577 KFTLGDDWVPKKLDVSVDMPDELDLSNWRSAGGLQPGEEALPEPA-----TEEVKFA-------- 628
            |||.|.||||||||||:|:|||||||.:| .||||.|||.||:.|     .:|.|.:
Frog   573 KFTFGLDWVPKKLDVSIDVPDELDLSEFR-GGGLQGGEEELPDVAPPLVTPDEPKGSLGFYGLDD 636

  Fly   629 ----------------FDEAVMSELLTMGFPPEACKRACYHTKNSGLEAASNWLMEHIADEDISE 677
                            .||:|:::|:.||||.|||::|.|:|.|||.|||..|:|.|:.|.|.:.
Frog   637 DDSYCSPHFSSPTSPVLDESVVTQLVEMGFPAEACRKAVYYTGNSGAEAAMTWVMSHMDDPDFAL 701

  Fly   678 PFVVPNNSIGDCAANQFVA------NPESLAMLMSMGFDERQAVAALKATDGNVERATDWIFSHA 736
            |       :...:|...|.      :.|.:|.::||||.:.|||.||:||:.|:|||.||||||.
Frog   702 P-------LSGASAPSSVTTGGDPPSEEHVATIISMGFSQEQAVKALRATNNNLERAVDWIFSHI 759

  Fly   737 DSIGVEDAAPAANSSAAAAS---STPNK-TNYRDGRGKYRLVAFISHMGTSAQVGHYVCHIRKKG 797
            |.:..|.|...:...:||.|   |.|.. ...|||.|:|.|.|||||||||...|||||||:|:|
Frog   760 DDLDAEAAMDLSEGRSAAESVSESLPAAGPRVRDGAGRYELFAFISHMGTSTMCGHYVCHIKKEG 824

  Fly   798 EWVIFNDSKVAKSQNPPKDLGYLYLYMREQ 827
            .|||:||.||..|:.|||||||:|.|.|.|
Frog   825 RWVIYNDQKVCASEKPPKDLGYIYFYQRIQ 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp5	NP_001246589.1	UBP14	24..825	CDD:227532	418/855 (49%)
		zf-UBP	204..278	CDD:280334	52/73 (71%)
		Peptidase_C19B	333..823	CDD:239123	248/535 (46%)
		UBA1_UBP5_like	631..674	CDD:270480	23/42 (55%)
		UBA2_UBP5	696..737	CDD:270569	23/46 (50%)
usp5	XP_012821494.1	UBP14	17..853	CDD:227532	420/867 (48%)
usp5	XP_012821494.1	Peptidase_C19B	326..851	CDD:239123	248/536 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	480	1.000	Domainoid score	I418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55758
Inparanoid	1	1.050	790	1.000	Inparanoid score	I504
OMA	1	1.010	-	-		QHG53559
OrthoDB	1	1.010	-	-		D556111at2759
OrthoFinder	1	1.000	-	-		FOG0002129
OrthoInspector	1	1.000	-	-		otm48493
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2324
SonicParanoid	1	1.000	-	-		X1410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110