DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg2 and ALG2

DIOPT Version :9

Sequence 1:	NP_647772.1	Gene:	Alg2 / 38374	FlyBaseID:	FBgn0035401	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_149078.1	Gene:	ALG2 / 85365	HGNCID:	23159	Length:	416	Species:	Homo sapiens

Alignment Length:	413	Identity:	211/413 - (51%)
Similarity:	276/413 - (66%)	Gaps:	18/413 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLFLHPDLGIGGAERLVVDAALALKERGHQVSFLTNHHDSTHCFKETADGTFPVHVVGDWLPRGL 68
            |||||||||:|||||||:||||||:.||..|...|.|:|..|||.|:.:  .||...||||||||
Human    17 VLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTAHYDPGHCFAESRE--LPVRCAGDWLPRGL 79

  Fly    69 --FGRFYAICAYLRMLYAAIYASFFMPQREQVDVVVCDLISVCIPVLRFAPHRPKVLFYCHFPDQ 131
              .||..|:|||:||::.|:|..|...  |:.||||||.:|.||||.|.|..|.|:||||||||.
Human    80 GWGGRGAAVCAYVRMVFLALYVLFLAD--EEFDVVVCDQVSACIPVFRLARRRKKILFYCHFPDL 142

  Fly   132 LLSSREGLLKRLYRLPINWLEEHTIGLADKVLVNSKFTLRVFQDTFRRLSTV-PDVLYPSLHTQY 195
            ||:.|:..||||||.||:|:||:|.|:||.:||||:||..||::||:.||.: ||||||||:...
Human   143 LLTKRDSFLKRLYRAPIDWIEEYTTGMADCILVNSQFTAAVFKETFKSLSHIDPDVLYPSLNVTS 207

  Fly   196 FDQMQKKLEQRSALLDEPVHPRVPL-NAFIYLDINRYERKKNHALALHSLRLLGDMLPATDFKRC 259
            ||          :::.|.:...||. ..|:.|.|||||||||..|||.:|..|...|.:.|::|.
Human   208 FD----------SVVPEKLDDLVPKGKKFLLLSINRYERKKNLTLALEALVQLRGRLTSQDWERV 262

  Fly   260 RLIIAGGYDTRCMENVEHFAELEHLTEELKLQDHVVLLRSPTDEEKCRLLFAAHCLLYTPENEHF 324
            .||:|||||.|.:|||||:.||:.:.::..|..:|..|||.:|::|..||.:..|:||||.||||
Human   263 HLIVAGGYDERVLENVEHYQELKKMVQQSDLGQYVTFLRSFSDKQKISLLHSCTCVLYTPSNEHF 327

  Fly   325 GIVPLEGMYCSKPVVALNSGGPTETVVSTSTGFLCEKTEKSFGGAMLQLFRDEQLRVKMGDQGHK 389
            ||||||.||...||:|:|||||.|::..:.||||||.....|..|:.:..|:..|:..||..|..
Human   328 GIVPLEAMYMQCPVIAVNSGGPLESIDHSVTGFLCEPDPVHFSEAIEKFIREPSLKATMGLAGRA 392

  Fly   390 RVQQKFSFQAFADRLNGIIRDLV 412
            ||::|||.:||.::|...:..|:
Human   393 RVKEKFSPEAFTEQLYRYVTKLL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg2	NP_647772.1	RfaB	1..412	CDD:223515	210/411 (51%)
Alg2	NP_647772.1	GT1_ALG2_like	2..404	CDD:99977	209/403 (52%)
ALG2	NP_149078.1	GT1_ALG2_like	16..407	CDD:99977	209/403 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159958
Domainoid	1	1.000	195	1.000	Domainoid score	I3169
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5930
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1950
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53746
OrthoDB	1	1.010	-	-		D1339573at2759
OrthoFinder	1	1.000	-	-		FOG0005034
OrthoInspector	1	1.000	-	-		oto88362
orthoMCL	1	0.900	-	-		OOG6_102563
Panther	1	1.100	-	-	LDO	PTHR45918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R41
SonicParanoid	1	1.000	-	-		X3559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800