DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg2 and ALG2

DIOPT Version :9

Sequence 1:	NP_647772.1	Gene:	Alg2 / 38374	FlyBaseID:	FBgn0035401	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_011450.1	Gene:	ALG2 / 852815	SGDID:	S000003033	Length:	503	Species:	Saccharomyces cerevisiae

Alignment Length:	448	Identity:	167/448 - (37%)
Similarity:	237/448 - (52%)	Gaps:	65/448 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLFLHPDLGIGGAERLVVDAALALKERGHQVSFLTNHHDSTHCFKETADGTFPVHVVGDWLPRGL 68
            :.|:||||||||||||||||||.|:::||.|...|:|.|.:|||:|..:|...|.|.||:||...
Yeast     9 IAFIHPDLGIGGAERLVVDAALGLQQQGHSVIIYTSHCDKSHCFEEVKNGQLKVEVYGDFLPTNF 73

  Fly    69 FGRFYAICAYLRMLYAAIYASFFMPQREQVDVVVCDLISVCIPVLRFAPHRPKVLFYCHFPDQLL 133
            .|||:.:.|.:|.||..|.. ....:.....:::.|.:|.|||:|... ....::||||||||||
Yeast    74 LGRFFIVFATIRQLYLVIQL-ILQKKVNAYQLIIIDQLSTCIPLLHIF-SSATLMFYCHFPDQLL 136

  Fly   134 SSREGLLKRLYRLPINWLEEHTIGLADKVLVNSKFTLRVFQDTFRRLSTVPDVLYP--SLHTQYF 196
            :.|.||||::||||.:.:|:.::..||.|:|||.||...|..||:.||..|||:||  .|.|...
Yeast   137 AQRAGLLKKIYRLPFDLIEQFSVSAADTVVVNSNFTKNTFHQTFKYLSNDPDVIYPCVDLSTIEI 201

  Fly   197 DQMQKKLEQRSALLDEPVHPRVPLNAFIYLDINRYERKKNHALALHSLRLLGDMLPATDFKRCRL 261
            :.:.||..:  .:.:|        ....||.|||:|:||:.|||:.:..|..|.:.    ...:|
Yeast   202 EDIDKKFFK--TVFNE--------GDRFYLSINRFEKKKDVALAIKAFALSEDQIN----DNVKL 252

  Fly   262 IIAGGYDTRCMENVEHFAELEHLTEELKL----------------------QDHVVLLRSPTDEE 304
            :|.||||.|..||||:..||:.|.:|.:|                      ...::.|.|.:...
Yeast   253 VICGGYDERVAENVEYLKELQSLADEYELSHTTIYYQEIKRVSDLESFKTNNSKIIFLTSISSSL 317

  Fly   305 KCRLLFAAHCLLYTPENEHFGIVPLEGMYCSKPVVALNSGGPTETV--------VSTSTGFL--- 358
            |..||.....|||||..|||||||||.|...|||:|:|:|||.||:        .|::||:|
Yeast   318 KELLLERTEMLLYTPAYEHFGIVPLEAMKLGKPVLAVNNGGPLETIKSYVAGENESSATGWLKPA 382

  Fly   359 --------CEKTEKSFGGAMLQLFRDEQLRVKMGDQGHKRVQQKFSFQAFADRLNGII 408
                    .:::.|......:...|:..||||      |...::...|:|.:.:..:|
Yeast   383 VPIQWATAIDESRKILQNGSVNFERNGPLRVK------KYFSREAMTQSFEENVEKVI 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg2	NP_647772.1	RfaB	1..412	CDD:223515	167/448 (37%)
Alg2	NP_647772.1	GT1_ALG2_like	2..404	CDD:99977	166/442 (38%)
ALG2	NP_011450.1	GT4_ALG2-like	7..426	CDD:340834	165/438 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346618
Domainoid	1	1.000	156	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5930
Inparanoid	1	1.050	270	1.000	Inparanoid score	I604
Isobase	1	0.950	-	0	Normalized mean entropy	S1110
OMA	1	1.010	-	-		QHG53746
OrthoFinder	1	1.000	-	-		FOG0005034
OrthoInspector	1	1.000	-	-		oto98956
orthoMCL	1	0.900	-	-		OOG6_102563
Panther	1	1.100	-	-	LDO	PTHR45918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R41
SonicParanoid	1	1.000	-	-		X3559
TreeFam	1	0.960	-	-
	16	15.740