DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg2 and Alg2

DIOPT Version :9

Sequence 1:	NP_647772.1	Gene:	Alg2 / 38374	FlyBaseID:	FBgn0035401	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_064382.3	Gene:	Alg2 / 56737	MGIID:	1914731	Length:	415	Species:	Mus musculus

Alignment Length:	413	Identity:	210/413 - (50%)
Similarity:	266/413 - (64%)	Gaps:	18/413 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLFLHPDLGIGGAERLVVDAALALKERGHQVSFLTNHHDSTHCFKETADGTFPVHVVGDWLPR-- 66
            |||||||:|||||||||:||||||:|.|..|...|.|:|..|||.||.:  ..|...||||||
Mouse    17 VLFLHPDMGIGGAERLVLDAALALQEYGCDVKIWTAHYDPNHCFIETRE--LSVQCAGDWLPRSL 79

  Fly    67 GLFGRFYAICAYLRMLYAAIYASFFMPQREQVDVVVCDLISVCIPVLRFAPHRPKVLFYCHFPDQ 131
            |..||..|||:|:||::.|:|..|.  ..|:.||||||.:|.||||.:.|..|.:|||||||||.
Mouse    80 GWGGRGAAICSYVRMVFLALYVLFL--SGEEFDVVVCDQVSACIPVFKLARRRKRVLFYCHFPDL 142

  Fly   132 LLSSREGLLKRLYRLPINWLEEHTIGLADKVLVNSKFTLRVFQDTFRRLS-TVPDVLYPSLHTQY 195
            ||:.|...||:.||.||:|:||:|.|:||::||||::|..||::||:.|| ..||||||||:...
Mouse   143 LLTQRNSALKKFYRAPIDWIEEYTTGMADRILVNSQYTASVFKETFKTLSHRNPDVLYPSLNIGS 207

  Fly   196 FDQMQKKLEQRSALLDEPVHPRVPL-NAFIYLDINRYERKKNHALALHSLRLLGDMLPATDFKRC 259
            ||          ..:.|.:...||. ..|::|.|||||||||..|||.||..|.:.||:.::.:.
Mouse   208 FD----------LAIPEKIDDLVPKGKQFLFLSINRYERKKNLPLALRSLVQLRNRLPSQEWDKV 262

  Fly   260 RLIIAGGYDTRCMENVEHFAELEHLTEELKLQDHVVLLRSPTDEEKCRLLFAAHCLLYTPENEHF 324
            .|.:|||||.|..|||||:.||:.:.:|..|:.||..|||.:|.:|..||....|:||||.||||
Mouse   263 HLFMAGGYDDRIPENVEHYKELKKMVQESDLERHVTFLRSFSDRQKISLLHGCLCVLYTPSNEHF 327

  Fly   325 GIVPLEGMYCSKPVVALNSGGPTETVVSTSTGFLCEKTEKSFGGAMLQLFRDEQLRVKMGDQGHK 389
            ||||||.||...||:|:|:|||.|::|...||||||.....|..||.:......|:..||..|..
Mouse   328 GIVPLEAMYMQCPVIAVNNGGPLESIVHKVTGFLCEPDPVHFSEAMEKFIHKPSLKATMGLAGKA 392

  Fly   390 RVQQKFSFQAFADRLNGIIRDLV 412
            ||.:|||..||||:|...:..||
Mouse   393 RVAEKFSADAFADQLYQYVTKLV 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg2	NP_647772.1	RfaB	1..412	CDD:223515	208/411 (51%)
Alg2	NP_647772.1	GT1_ALG2_like	2..404	CDD:99977	207/403 (51%)
Alg2	NP_064382.3	GT4_ALG2-like	17..407	CDD:340834	200/393 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850329
Domainoid	1	1.000	185	1.000	Domainoid score	I3380
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5930
Inparanoid	1	1.050	390	1.000	Inparanoid score	I1980
Isobase	1	0.950	-	0	Normalized mean entropy	S1110
OMA	1	1.010	-	-		QHG53746
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005034
OrthoInspector	1	1.000	-	-		oto91932
orthoMCL	1	0.900	-	-		OOG6_102563
Panther	1	1.100	-	-	LDO	PTHR45918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R41
SonicParanoid	1	1.000	-	-		X3559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740