DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alg2 and Alg2

DIOPT Version :9

Sequence 1:	NP_647772.1	Gene:	Alg2 / 38374	FlyBaseID:	FBgn0035401	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_001094180.1	Gene:	Alg2 / 313231	RGDID:	1309940	Length:	415	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	212/413 - (51%)
Similarity:	267/413 - (64%)	Gaps:	18/413 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLFLHPDLGIGGAERLVVDAALALKERGHQVSFLTNHHDSTHCFKETADGTFPVHVVGDWLPR-- 66
            |||||||:|||||||||:||||||:|.|.||...|.|:|..|||.||.:  ..|...||||||
  Rat    17 VLFLHPDMGIGGAERLVLDAALALQEYGCQVKIWTAHYDPNHCFIETRE--LSVQCAGDWLPRSL 79

  Fly    67 GLFGRFYAICAYLRMLYAAIYASFFMPQREQVDVVVCDLISVCIPVLRFAPHRPKVLFYCHFPDQ 131
            |..||..|||:|:||::.|:|..|.  ..|:.||||||.:|.||||.:.|..|.:|||||||||.
  Rat    80 GWGGRGAAICSYVRMVFLALYVLFL--SGEEFDVVVCDQVSACIPVFKLARRRKRVLFYCHFPDL 142

  Fly   132 LLSSREGLLKRLYRLPINWLEEHTIGLADKVLVNSKFTLRVFQDTFRRLS-TVPDVLYPSLHTQY 195
            ||:.|...||:.||.||:|:||:|.|:||::||||::|..||::||:.|| ..||||||||:...
  Rat   143 LLTQRNSSLKKFYRAPIDWIEEYTTGMADRILVNSQYTASVFKETFKTLSHRNPDVLYPSLNIGS 207

  Fly   196 FDQMQKKLEQRSALLDEPVHPRVPL-NAFIYLDINRYERKKNHALALHSLRLLGDMLPATDFKRC 259
            ||          ..:.|.:...||. ..|::|.|||||||||..|||.||..|...||..::::.
  Rat   208 FD----------LAVPEKIDDLVPKGKQFLFLSINRYERKKNLPLALSSLVQLRARLPPQEWEKV 262

  Fly   260 RLIIAGGYDTRCMENVEHFAELEHLTEELKLQDHVVLLRSPTDEEKCRLLFAAHCLLYTPENEHF 324
            .|.:|||||.|.:|||||:.||:.:.:|..|:.||..|||.:|.:|..||....|:||||.||||
  Rat   263 HLFMAGGYDDRVLENVEHYKELKKIVQESDLERHVTFLRSFSDRQKISLLHGCLCVLYTPSNEHF 327

  Fly   325 GIVPLEGMYCSKPVVALNSGGPTETVVSTSTGFLCEKTEKSFGGAMLQLFRDEQLRVKMGDQGHK 389
            ||||||.||...||:|:|||||.|::|...||||||.....|..||.:......|:..||..|..
  Rat   328 GIVPLEAMYMQCPVIAVNSGGPLESIVHKVTGFLCEPDPVHFSEAMEKFIHKPSLKATMGLAGKA 392

  Fly   390 RVQQKFSFQAFADRLNGIIRDLV 412
            ||.:|||..||||:|...:..||
  Rat   393 RVAEKFSADAFADQLYQYVTKLV 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg2	NP_647772.1	RfaB	1..412	CDD:223515	210/411 (51%)
Alg2	NP_647772.1	GT1_ALG2_like	2..404	CDD:99977	209/403 (52%)
Alg2	NP_001094180.1	GT4_ALG2-like	17..407	CDD:340834	202/393 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354027
Domainoid	1	1.000	187	1.000	Domainoid score	I3246
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5930
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1921
OMA	1	1.010	-	-		QHG53746
OrthoDB	1	1.010	-	-		D1339573at2759
OrthoFinder	1	1.000	-	-		FOG0005034
OrthoInspector	1	1.000	-	-		oto95505
orthoMCL	1	0.900	-	-		OOG6_102563
Panther	1	1.100	-	-	LDO	PTHR45918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3559
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770