DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11537 and ARN1

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_011823.1	Gene:	ARN1 / 856345	SGDID:	S000001032	Length:	627	Species:	Saccharomyces cerevisiae

Alignment Length:	575	Identity:	117/575 - (20%)
Similarity:	199/575 - (34%)	Gaps:	187/575 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 GCDLRQSPPSSSSSSSSTSTSPQTS-RYAAAAAHPSAAFAETAITASSG-----------SGRVC 191
            |.:...:|.:.:.|:|.:...||.| :|.|...:.|....:|.|..|:.           |..:|
Yeast    20 GMEHELNPETHNDSNSDSYGLPQLSEKYNALRQNRSLIIQQTEIIGSAYNKWYLQAILLLSAFIC 84

  Fly   192 G-GSG------------GAAHRRTHSAASYISMRSQ--GGNSEATPERPKR--NRFFEWIR---- 235
            | |.|            ..:....||..|.|::.:.  ...|:....|...  .|.:.:|.
Yeast    85 GYGYGLDGNIRYIYTGYATSSYSEHSLLSTINVINAVVSAASQIIYARLSDVFGRLYLFISAVIL 149

  Fly   236 -VVCNICCCKSSGI------------GEPSVHHALVVIFLEF--FAWGLLTMPIISTLNQTFPDH 285
             ||..|...::..:            |...|...|::|..:|  ..|.|        |.|..|..
Yeast   150 YVVGTIIQSQAYDVQRYAAGAIFYNAGYVGVILILLIILSDFSSLKWRL--------LYQFVPTW 206

  Fly   286 TFLMNGLVMGIKGILSFLSAPLIGALSDI--WGRKFFLLVTVFFTCLPIPLMSINTWWFFAMISI 348
            .|::|   ..|.|.::..:.|::....|:  |...|.|      :|:||.|..::..|
Yeast   207 PFIIN---TWIAGNITSRANPVVNWSWDVGMWAFIFPL------SCVPIVLCMLHMQW------- 255

  Fly   349 SGAFAVTFSVVFAYVADVTTPE----ERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVAL 409
                           ....|||    :..|:|                     .:.:|  .:..|
Yeast   256 ---------------RARKTPEWHALKGQKSY---------------------YQEHG--FIKIL 282

  Fly   410 STAIALLDVFFIL--------VAVPESLSEKMRPASWG--------------APISW-----EQA 447
            .....:|||..:|        :.||.:|:..:: .:|.              .||.|     ...
Yeast   283 KQLFWMLDVVGVLLMGCSLGCILVPLTLAGGVK-TTWNDSRLIGPFVLGFVLIPILWIWEYRFAR 346

  Fly   448 DPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAI-VGILSIT 511
            ||.|..|.| .|:.|..   ::.:|:|.:       |:|.   |..:|:...:.:|: ..:.|.|
Yeast   347 DPILPYRLV-KDRAVWS---SMGISFLID-------FIYY---MAADYLYTVMIVAVNESVKSAT 397

  Fly   512 VQVTLGSFMQVFGA-------------KRTIIMGLALEIVQL-LWYGF--GSQKWMMWSAGVVAA 560
            ...||.||:....:             |..|:.|.||.:|.: |.|.|  |||.    .:|::.|
Yeast   398 RIATLSSFVSTVASPFFALLVTRCTRLKPFIMFGCALWMVAMGLLYHFRGGSQS----HSGIIGA 458

  Fly   561 L-----GS--ITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 608
            |     |:  .||| ::..|....:.|:...|..:...:..:.:.:|.||.|.::
Yeast   459 LCVWGVGTTLFTYP-VTVSVQSAVSHENMATVTALNYTLYRIGSAVGSAVSGAIW 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	86/412 (21%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	82/402 (20%)
ARN1	NP_011823.1	MFS_ARN_like	74..586	CDD:340880	104/521 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930