DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11537 and TPO3

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_015482.1	Gene:	TPO3 / 856279	SGDID:	S000006360	Length:	622	Species:	Saccharomyces cerevisiae

Alignment Length:	730	Identity:	147/730 - (20%)
Similarity:	237/730 - (32%)	Gaps:	231/730 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ADRERQESGEQTDSLSTRSSSSTPTTADVADVETISSLPLSPPAFGGRGNQLVKRHSPLKDKQAE 115
            :|.|.|:..:...|.|...|:..|....:...||:.||.          :..|...:|:.|..|.
Yeast    19 SDVESQQPQQYIPSESGSKSNMAPNQLKLTRTETVKSLQ----------DMGVSSKAPVPDVNAP 73

  Fly   116 QADSSSSSSCSQQPDADDVPTVSGCDLRQSPPSSSSSSSSTST--SPQTSRYAAAAAHPSAAFAE 178
            |     ||.....|:...:.|.:|.    .|.::..|...|||  |...:|....|:.||:  .|
Yeast    74 Q-----SSKNKIFPEEYTLETPTGL----VPVATLHSIGRTSTAISRTRTRQIDGASSPSS--NE 127

  Fly   179 TAITASSGSGRVCGGSGGAAHRRTHSAASYISMRSQGGNSEA---------------TPERPKRN 228
            .|:.:.:......|.|.||                   |.||               .||.|  :
Yeast   128 DALESDNNEKGKEGDSSGA-------------------NDEAPDLDPEIEFVTFVTGDPENP--H 171

  Fly   229 RFFEWIR----------VVCNI--CCCKSSGIG--EPSVHHALVVIFLEFFAWGLLTMPIISTLN 279
            .:..|||          |:|..  ..|.|.|:|  |...|..:....|.           :|.:
Yeast   172 NWPAWIRWSYTVLLSILVICVAYGSACISGGLGTVEKKYHVGMEAAILS-----------VSLM- 224

  Fly   280 QTFPDHTFLMNGLVMGIKGILSFLSAPLI-GALSDIWGRKFFLLVTV-FFTCLPIP-LMSINTWW 341
                               ::.|...||| ..:||::||:....|:: .:....|| .::.|...
Yeast   225 -------------------VIGFSLGPLIWSPVSDLYGRRVAYFVSMGLYVIFNIPCALAPNLGS 270

  Fly   342 FFAMISISGAFAVT-FSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALG---NALMEMYG 402
            ..|...:.|.::.: ..:|...:||:...|.|.||.    |.||.:..:.|.:|   |..:.:..
Yeast   271 LLACRFLCGVWSSSGLCLVGGSIADMFPSETRGKAI----AFFAFAPYVGPVVGPLVNGFISVST 331

  Fly   403 DTLVVALSTAIALLDVFFIL-VAVPE--------------------------------SLSEKMR 434
            ..:.:.....:|...|.:|: .|:||                                |:.|.||
Yeast   332 GRMDLIFWVNMAFAGVMWIISSAIPETYAPVILKRKAARLRKETGNPKIMTEQEAQGVSMGEMMR 396

  Fly   435 PASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSY-----LPEA-GEYSCMFVYLKLKMGF 493
             |....|:.:...:|.|.       .|...:||...|.|     .|.. ||   ::.|....:|.
Yeast   397 -ACLLRPLYFSVTEPVLV-------ATCFYVCLIYSLLYAFFFAFPVIFGE---LYGYKDNLVGL 450

  Fly   494 NYVEVSVFIAIVGIL--SITVQVTLGSFMQV------------FGAKRTIIMGLALEIVQLLWYG 544
            .::.:     ::|.|  ..|.......::|:            .|||    :|.....:.|...|
Yeast   451 MFIPI-----VIGALWALATTFYCENKYLQIVKQRKPTPEDRLLGAK----IGAPFAAIALWILG 506

  Fly   545 FGSQKWMMW----SAGVVAALGS--ITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAV 603
            ..:.|.::|    |||:....|.  |.|...:..:..|....|               :.|...|
Yeast   507 ATAYKHIIWVGPASAGLAFGFGMVLIYYSLNNYIIDCYVQYAS---------------SALATKV 556

  Fly   604 F-----GVVFYLFNVDLNDDHDSHAKSSGSRATNVEKISQHVPGPPFVFGALCVFCAIIVSAFIP 663
            |     |..|.||.:.:....:.|..|     ..:..||..:...||.|            ::..
Yeast   557 FLRSAGGAAFPLFTIQMYHKLNLHWGS-----WLLAFISTAMIALPFAF------------SYWG 604

  Fly   664 EGQTSTLEKKRASLD 678
            :|....|.||..|:|
Yeast   605 KGLRHKLSKKDYSID 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	79/426 (19%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	74/409 (18%)
TPO3	NP_015482.1	MFS_Tpo1_MDR_like	182..608	CDD:340881	96/512 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910