DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11537 and QDR2

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_012145.1	Gene:	QDR2 / 854685	SGDID:	S000001383	Length:	542	Species:	Saccharomyces cerevisiae

Alignment Length:	561	Identity:	111/561 - (19%)
Similarity:	186/561 - (33%)	Gaps:	149/561 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 RSQGGNSEATPERPKRNRFFEWIRVVCNICCCKSSGIGEPSVHHALVVIFLEFFAW--GLLTMPI 274
            |::....|.....|..:||....:.|....|.                 |..||:.  |.:..|:
Yeast    37 RTESVKPEPEITAPPHSRFSRSFKTVLIAQCA-----------------FTGFFSTIAGAIYYPV 84

  Fly   275 ISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTV---FFTCLPIPLMS 336
            :|.:.:.|.....|:|..|: :..:...|:...:|..:|..||:..:||.:   |..|  |.|..
Yeast    85 LSVIERKFDIDEELVNVTVV-VYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGAC--IGLAC 146

  Fly   337 INTWWFFAMI---------SISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPA 392
            ..|   :|.|         .||...|:...:    :.||||..||....|..:............
Yeast   147 AQT---YAQIIVLRCLQAAGISPVIAINSGI----MGDVTTRAERGGYVGYVAGFQVLGSAFGAL 204

  Fly   393 LGNALMEMYGDTLV---VALSTAIALLDVFFILVAVPESLS--EKMRPASW--GAPI-------- 442
            :|..|...:|...:   :|:.:.|..|..|.||.....::|  ..:.|.|:  .|||
Yeast   205 IGAGLSSRWGWRAIFWFLAIGSGICFLASFLILPETKRNISGNGSVTPKSYLNRAPILVLPTVRK 269

  Fly   443 SWEQADPFLALRKVGTDKTVLM---------LCLTVLLSYLPEAGEYSCMFVYLKLKMGFNY--- 495
            |....:|.....::.|...:|.         :|:.:|::.| :...|:.....|...:...|
Yeast   270 SLHLDNPDYETLELPTQLNLLAPFKILKAYEICILMLVAGL-QFAMYTTHLTALSTALSKQYHLT 333

  Fly   496 -VEVSVFIAIVGILSITVQVTLGSFM------------QVFGAKRTIIM---GLALEIVQLL--- 541
             .:|.:.....||.::...|..|.::            ...|.||:.::   ...|.:||.:
Yeast   334 VAKVGLCYLPSGICTLCSIVIAGRYLNWNYRRRLKYYQNWLGKKRSKLLEEHDNDLNLVQRIIEN 398

  Fly   542 --WYGFGSQKWMMWSAGVVAALGS---------ITYPA-------ISAFVSLYA----------- 577
              .|.|...|..:..|.|...|.|         ||..|       :|.|.||::
Yeast   399 DPKYTFNIFKARLQPAFVTLLLSSSGFCAYGWCITVKAPLAAVLCMSGFASLFSNCILTFSTTLI 463

  Fly   578 ---APESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLNDDHDSHAKSSGSRATNVEKISQH 639
               .|.......|        |..|...:...||.                 .:.:..|||:..
Yeast   464 VDLFPTKTSTATG--------CLNLFRCILSAVFI-----------------AALSKMVEKMKF- 502

  Fly   640 VPGPPFVF-GALCVFCAIIVSAFIPEGQTSTLEKKRASLDV 679
              |..|.| |||....:|::...:.:|:....::|:..|.|
Yeast   503 --GGVFTFLGALTSSSSILLFILLRKGKELAFKRKKQELGV 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	90/447 (20%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	88/435 (20%)
QDR2	NP_012145.1	MFS_Tpo1_MDR_like	64..530	CDD:340881	102/521 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341879
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930