DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11537 and SLC18A1

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001129163.1	Gene:	SLC18A1 / 6570	HGNCID:	10934	Length:	525	Species:	Homo sapiens

Alignment Length:	375	Identity:	72/375 - (19%)
Similarity:	138/375 - (36%)	Gaps:	104/375 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVT 355
            |::...|.::..|..|.:|.|::..|  :.:.:...|.     :|.::|    .|.:.||.:.:.
Human   140 GVLFASKAVMQLLVNPFVGPLTNRIG--YHIPMFAGFV-----IMFLST----VMFAFSGTYTLL 193

  Fly   356 F--------SVVFAYVADV-------TTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTL 405
            |        ...|:.||.:       |...||.:|.|.|....|..|::....|:.:.|..|.:.
Human   194 FVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSA 258

  Fly   406 VVALSTAIALLD-VFFILVAVPESLSEKMRPASWGAPISWEQADPF-------LALRKVGT---D 459
            ...:...:|||| ...:.:..|..:|.:   ::.|.|:.....||:       :....:|.   :
Human   259 PFLILAFLALLDGALQLCILQPSKVSPE---SAKGTPLFMLLKDPYILVAAGSICFANMGVAILE 320

  Fly   460 KTVLMLCLTVL--------LSYLPEAGEY---SCMFVYLKLKMGFNYVEVSVFIAIVGI------ 507
            .|:.:..:..:        |::||.:..|   :.:|..|..||| .::...:.:.:||.
Human   321 PTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMG-RWLCSLIGMLVVGTSLLCVP 384

  Fly   508 --------------LSITVQVTLGSFMQVFG-----------------AKRTIIMGLAL------ 535
                          |.:.:.:...|.|.:.|                 |.....||.|:
Human   385 LAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRHTSVYGSVYAIADVAFCMGFAIGPSTGG 449

  Fly   536 EIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAISAFVSLYAAPESQGAV 585
            .||:.:  ||   .|:|...||:    :|.|..:..::....|.|.:.|:
Human   450 AIVKAI--GF---PWLMVITGVI----NIVYAPLCYYLRSPPAKEEKLAI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	72/375 (19%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	72/375 (19%)
SLC18A1	NP_001129163.1	MFS_1	139..445	CDD:284993	59/319 (18%)
		2_A_01_02	140..281	CDD:273318	32/151 (21%)
		MFS	302..>479	CDD:119392	31/186 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..525
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910