DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11537 and MFSD14A

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_149044.2	Gene:	MFSD14A / 64645	HGNCID:	23363	Length:	490	Species:	Homo sapiens

Alignment Length:	427	Identity:	274/427 - (64%)
Similarity:	334/427 - (78%)	Gaps:	16/427 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 GIGEPSVHHALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGAL 311
            |||.|||:||::|||||||||||||.|.:..|::|||.||||||||:.|:||:||||||||||||
Human    31 GIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGAL 95

  Fly   312 SDIWGRKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAY 376
            ||:||||.|||:||||||.|||||.|:.||:||:||:||.||||||||||||||:|...|||.||
Human    96 SDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAY 160

  Fly   377 GLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAP 441
            ||.|||||||||.|||:|..|..:|||:|||.|:|||||||:.||||||||||.|||||||||||
Human   161 GLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESLPEKMRPASWGAP 225

  Fly   442 ISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVG 506
            |||||||||.:|:|||.|..||::|:||.||||||||:||..|:||:..|.|:...|:.|||::|
Human   226 ISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIAVLG 290

  Fly   507 ILSITVQ-VTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAIS 570
            ||||..| :.|...|:..|.|.||::||..:|:||.||||||:.||||:||.|||:.|||:||:|
Human   291 ILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 355

  Fly   571 AFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLNDDHDSHAKSSGS-RATNVE 634
            |.||..|..:.||.|||||||:||||||||||::|.:||:|:|:|.:     ...:|: ..||..
Human   356 ALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKE-----LPITGTDLGTNTS 415

  Fly   635 KISQH-------VPGPPFVFGALCVFCAIIVSAFIPE 664
              .||       :|||||:|||..|..|::|:.||||
Human   416 --PQHHFEQNSIIPGPPFLFGACSVLLALLVALFIPE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	244/356 (69%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	237/344 (69%)
MFSD14A	NP_149044.2	MFS_MFSD14	37..449	CDD:340945	266/418 (64%)
MFSD14A	NP_149044.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142519
Domainoid	1	1.000	491	1.000	Domainoid score	I371
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1135
Isobase	1	0.950	-	0	Normalized mean entropy	S2848
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	1	1.000	-	-		otm40924
orthoMCL	1	0.900	-	-		OOG6_102321
Panther	1	1.100	-	-	LDO	PTHR23504
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4214
SonicParanoid	1	1.000	-	-		X1552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740