DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11537 and mfsd8

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_001038513.1	Gene:	mfsd8 / 564342	ZFINID:	ZDB-GENE-060818-29	Length:	504	Species:	Danio rerio

Alignment Length:	520	Identity:	104/520 - (20%)
Similarity:	188/520 - (36%)	Gaps:	152/520 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 SVHHALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWG 316
            ||...:|:..:    |     |.:..:::: .|.:||  |.|:....:...:::|..|..|:...
Zfish    42 SVGFTIVITSI----W-----PYLKKIDES-ADASFL--GWVVAAYSLGQMVASPFFGLWSNHRP 94

  Fly   317 RKFFLLVTVFFTCLPIPLMSINTWWFFAMISIS-------------GAFAVTFSVVFAYVADVTT 368
            |:..|:.::|..      :|.|.::.:..:..|             |..|...:||.:|||..|:
Zfish    95 RREPLVCSIFIN------VSANIYYSYVYLPPSHNQIHMLLARTFVGIGAGNVAVVRSYVAGATS 153

  Fly   369 PEERSKAYGLASATFAASLVISPALGNALMEMYGDT--------LVVALSTAIALLDVFF----- 420
            .:||:.|....||..|...::.||| .|::...|:|        |.|.:.||.|||...|
Zfish   154 LKERTSAMANMSACQALGFILGPAL-QAVLSFIGETGVSVDVIKLQVNMYTAPALLAACFGVINI 217

  Fly   421 ---ILVAVPESLSE---KMRPASW------GAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSY 473
               |||....|:.:   ::||.::      ..|...|.....:|   |.|...:..:.|.:...:
Zfish   218 LLVILVLREHSVDDHGNRIRPINYTPEERVDVPPEVEGDIDHIA---VFTSNVLFFIILFIFAVF 279

  Fly   474 LPEAGEYSC-MFVYL-KLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALE 536
            ...:...|. ||.:. |..:.:|    .:.:|.:|..||.|.:.:.......|.:..::.||.|.
Zfish   280 ETISTPLSMDMFAWTRKEAVLYN----GIILAAIGFESILVFLVVKVVSARVGDRPLLLGGLILI 340

  Fly   537 IV-------------QLLWYGFGS--------------------------QKWMMWSAGVVAA-- 560
            .|             ::.|....:                          |.|.:::..:..|
Zfish   341 FVGFFMLLPWGNQYPKIQWTDINNNTIPPIQLAPTPASNSSLEPIGCPSEQTWCLFTPVIHLAQY 405

  Fly   561 -----LGSITYPAISAF-VSLYA---APESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLN 616
                 |..:.||..:.. .:||:   .|:.||...|.:|........||| ||...||.
Zfish   406 ITSDILIGVGYPTCNVMSYTLYSKILGPKPQGVYMGWLTASGSGARTLGP-VFVSHFYT------ 463

  Fly   617 DDHDSHAKSSGSRATNVEKISQHVPGPPFVFGALCVFCAIIVSAFIPEGQTSTLEKKRASLDVQY 681
                                   :.||.:.|.|:   |.|:::|.:   ..|.:.|:..:..:::
Zfish   464 -----------------------ILGPRWAFSAI---CGIVLAAIV---MLSAMYKRLVAFSIRH 499

Fly 682 681
Zfish 500 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	93/445 (21%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	87/433 (20%)
mfsd8	NP_001038513.1	Dileucine internalization motif. /evidence=ECO:0000250	12..13
		MFS	31..489	CDD:119392	103/508 (20%)
		MFS_1	34..455	CDD:284993	89/438 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910