DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11537 and mfsd14a1

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_998692.2	Gene:	mfsd14a1 / 406848	ZFINID:	ZDB-GENE-040426-2935	Length:	485	Species:	Danio rerio

Alignment Length:	425	Identity:	269/425 - (63%)
Similarity:	334/425 - (78%)	Gaps:	15/425 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 GIGEPSVHHALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGAL 311
            |.|.|||:||::|||||||||||||.|.:..|::|||.||||||||:.|:||:||||||||||||
Zfish    29 GFGSPSVYHAVIVIFLEFFAWGLLTAPTLGALDETFPKHTFLMNGLIQGVKGLLSFLSAPLIGAL 93

  Fly   312 SDIWGRKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAY 376
            ||:||||.|||:||||||.|||||.|:.||:|||||:||.|||||||:||||||:|...|||.||
Zfish    94 SDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAMISVSGVFAVTFSVIFAYVADITQEHERSMAY 158

  Fly   377 GLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAP 441
            |:.|||||||||||||:|..|..:|||||||.|::|||:||:.||||||||||.|||||||||||
Zfish   159 GMVSATFAASLVISPAIGAYLSHVYGDTLVVVLASAIAMLDICFILVAVPESLPEKMRPASWGAP 223

  Fly   442 ISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVG 506
            |||||||||.:|||||.|.|||::|:||.||||||||:.|..|:||:..|||:...|:.|||::|
Zfish   224 ISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQNSSFFLYLQQIMGFSSESVAAFIAVLG 288

  Fly   507 ILSITVQ-VTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAIS 570
            :||:..| |.|...|:..|.|.||::||..:|:||.||||||:.||||:||.|||:.|||:||:|
Zfish   289 LLSVVAQTVVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS 353

  Fly   571 AFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLN------DDHDSHAKSSGSR 629
            |.:|..|.|:.||..|||:||:||||||||||::|.:||:|:|:|:      .|...|
Zfish   354 ALISRTADPDQQGVGQGMVTGIRGLCNGLGPALYGFIFYIFHVELDKVPEKGPDVQHH------- 411

  Fly   630 ATNVEKISQHVPGPPFVFGALCVFCAIIVSAFIPE 664
             .::.:.|..:|||||:|||..|..|::|:.||||
Zfish   412 -RDLHQQSAIIPGPPFLFGACSVLLALLVALFIPE 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	242/356 (68%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	235/344 (68%)
mfsd14a1	NP_998692.2	MFS	38..395	CDD:119392	242/356 (68%)
mfsd14a1	NP_998692.2	MFS_1	40..384	CDD:284993	235/343 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575223
Domainoid	1	1.000	510	1.000	Domainoid score	I315
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	1	1.000	-	-		otm26206
orthoMCL	1	0.900	-	-		OOG6_102321
Panther	1	1.100	-	-	LDO	PTHR23504
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4214
SonicParanoid	1	1.000	-	-		X1552
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790