DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11537 and mfsd14a2

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_955878.1	Gene:	mfsd14a2 / 322115	ZFINID:	ZDB-GENE-030131-834	Length:	493	Species:	Danio rerio

Alignment Length:	450	Identity:	293/450 - (65%)
Similarity:	347/450 - (77%)	Gaps:	6/450 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 TPERPKRNRFFEWIRVVCNICCCKS---SGIGEPSVHHALVVIFLEFFAWGLLTMPIISTLNQTF 282
            |.|:.|:.|....|.:...|.....   .|||||||:||:||||||||||||||.|:::.|.|||
Zfish     2 TGEKKKKKRLNRSILLAKKIIIKDGGTPQGIGEPSVYHAVVVIFLEFFAWGLLTTPMLAVLRQTF 66

  Fly   283 PDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSINTWWFFAMIS 347
            |.||||||||:.|:||:||||||||||||||:||||.|||:||||||.|||||.|:.||:||:||
Zfish    67 PQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVIS 131

  Fly   348 ISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 412
            :||.|||||||:||||||:|...|||.||||.|||||||||.|||:|..|.|:|||||||.|:||
Zfish   132 MSGVFAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSEVYGDTLVVILATA 196

  Fly   413 IALLDVFFILVAVPESLSEKMRPASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEA 477
            |||||:.||||||||||.||||||||||||||||||||.:|||||.|.|||::|:||.|||||||
Zfish   197 IALLDICFILVAVPESLPEKMRPASWGAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEA 261

  Fly   478 GEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQ-VTLGSFMQVFGAKRTIIMGLALEIVQLL 541
            |.||..|:||:..:||....|:.|||:||||||..| |.||..|:..|.|.||::||..:|:||.
Zfish   262 GPYSSFFLYLRQVIGFTSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLA 326

  Fly   542 WYGFGSQKWMMWSAGVVAALGSITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGV 606
            |||||||.||||:||.|||:.|||:|||||.||..|.|:.||.|||||||:||||||||||::|.
Zfish   327 WYGFGSQPWMMWAAGAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGF 391

  Fly   607 VFYLFNVDLN--DDHDSHAKSSGSRATNVEKISQHVPGPPFVFGALCVFCAIIVSAFIPE 664
            |||||:|:|:  |..:|..|.......|....|..:|||||:|||..|..:::|:.||||
Zfish   392 VFYLFHVELSEMDPAESPEKGVKPNMANPTDESAIIPGPPFLFGACSVLLSLLVALFIPE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	257/356 (72%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	248/344 (72%)
mfsd14a2	NP_955878.1	MFS	40..393	CDD:119392	253/352 (72%)
mfsd14a2	NP_955878.1	MFS_1	42..386	CDD:284993	248/343 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575219
Domainoid	1	1.000	510	1.000	Domainoid score	I315
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	1	1.000	-	-		otm26206
orthoMCL	1	0.900	-	-		OOG6_102321
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4214
SonicParanoid	1	1.000	-	-		X1552
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790