DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11537 and T25D3.4

DIOPT Version :9

Sequence 1:	NP_001097489.1	Gene:	CG11537 / 38373	FlyBaseID:	FBgn0035400	Length:	705	Species:	Drosophila melanogaster
Sequence 2:	NP_493670.2	Gene:	T25D3.4 / 188895	WormBaseID:	WBGene00020798	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	244/461 - (52%)
Similarity:	320/461 - (69%)	Gaps:	39/461 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 EPSVHHALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDI 314
            |.||.|||||||||:|||||||:|:|:.|.:|||.:.|||||||:|:||:||||||||:|||||:
Worm    72 EASVSHALVVIFLEYFAWGLLTVPVINVLAETFPTNKFLMNGLVLGVKGLLSFLSAPLVGALSDV 136

  Fly   315 WGRKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLA 379
            ||||.||::||..||:|||.:.|:.||:|::.|:||.|:|||||:.|||||:|...|||.||||.
Worm   137 WGRKAFLILTVLCTCMPIPCLKISPWWYFSLFSLSGLFSVTFSVILAYVADITDKSERSSAYGLV 201

  Fly   380 SATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASWG--AP- 441
            |||||||||.|||||..:.|:|||:|||.|:|.:::.||.||::.|||||..:....|..  .|
Worm   202 SATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNTGSVSQITPN 266

  Fly   442 --ISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAI 504
              .:|:.||||.:||.|..||.||.|...|.||||||:|::||.||||||.:||:...|:::|.:
Worm   267 EVFNWQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGL 331

  Fly   505 VGILSITVQV-TLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPA 568
            |||||:..|. .|......||.|.||.:||..:::||.|||.|:|.||||||||:||:.|||||:
Worm   332 VGILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITYPS 396

  Fly   569 ISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLNDDHDSHAKSSGSRATNV 633
            ||||||:.:..:.||.|||:|||:||||.|.|||:||.|||||:|||.|:     ||:|...:.|
Worm   397 ISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLFDVDLEDE-----KSTGGALSLV 456

  Fly   634 ------EKIS----------------------QHVPGPPFVFGALCVFCAIIVSAFIPEGQTSTL 670
                  |||.                      |.:|||||:.||:.|..|:::::.:|...|.:.
Worm   457 APRKIPEKILAPTRNESSWIQQQVDRAAAFDWQFIPGPPFLIGAMMVLFALLINSTLPHTPTPSK 521

  Fly   671 EKKRAS 676
            ..:|:|
Worm   522 YFRRSS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11537	NP_001097489.1	MFS	256..612	CDD:119392	214/361 (59%)
CG11537	NP_001097489.1	MFS_1	257..601	CDD:284993	204/349 (58%)
T25D3.4	NP_493670.2	MFS_MFSD14	75..514	CDD:340945	238/443 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167097
Domainoid	1	1.000	419	1.000	Domainoid score	I325
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I840
Isobase	1	0.950	-	0	Normalized mean entropy	S2848
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	1	1.000	-	-		otm14707
orthoMCL	1	0.900	-	-		OOG6_102321
Panther	1	1.100	-	-	LDO	PTHR23504
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4214
SonicParanoid	1	1.000	-	-		X1552
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740