DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment promL and prom2

DIOPT Version :9

Sequence 1:	NP_001261351.1	Gene:	promL / 38372	FlyBaseID:	FBgn0026189	Length:	1013	Species:	Drosophila melanogaster
Sequence 2:	NP_001289158.1	Gene:	prom2 / 556596	ZFINID:	ZDB-GENE-080723-16	Length:	830	Species:	Danio rerio

Alignment Length:	926	Identity:	187/926 - (20%)
Similarity:	345/926 - (37%)	Gaps:	232/926 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 RP---TTNYTKAPPPPTSA-MNPIFNFTHFLYDKVLYRDEPIPEGYIV--VKNSDTLSLGPKVEE 153
            ||   |.|.|::.....|| |.||.:  .||   .|.:..|.|:..:|  :.|.::.:....|:|
Zfish    34 RPELQTPNETQSQLTLNSAFMTPIVH--SFL---GLVQPNPFPKDLLVRMINNFNSNTQTEMVKE 93

  Fly   154 NDWRDLLAHYWMVLIWVVILVVLIIVIPFIAVCYCCFCCCRRC------RQGCPPCTSKQDAQRR 212
                 :|.:....|:.|.|.::.|:::|.|.:.:.|..||..|      :|     ||..:.:||
Zfish    94 -----VLNYEKGFLVCVAIGILYIVLMPLIGLIFACCRCCGNCGGRMQQKQ-----TSSTNCKRR 148

  Fly   213 --FCCGICLLILIIGLIFGIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLKDVADHVHHLMMY 275
              :|....:.:||:.   |.|..|::.       ..||||:|..|.:....|.||..:|..:
Zfish   149 SIYCSTFIITVLILA---GNICMFLST-------TYTSETVKSSSNEITGILDDVKGYVSSI--- 200

  Fly   276 NYEEMETHVLDQLTHAHRHIFLDLSDTSESNSLAEMERVLENMPEALELMRQVEKMEKDLRFYGS 340
              .:....|||:                   |...:::|..|:.|...|:             |.
Zfish   201 --PQQIQQVLDE-------------------SFLTVDQVKNNLNETGPLL-------------GG 231

  Fly   341 QLRDGVRGIKRDVNFAVANLCQLQMCQKFLISSNIEHIDSSQCLHF-DNLPNTKEFVEGMENIVA 404
            .:::   |:|..:|.|..::.|:..    :|:|.     |:..||. :.|...|..::.::
Zfish   232 LIQN---GLKDSLNPAFNSITQIAQ----VINST-----STGLLHVNETLGQPKPKIDALK---- 280

  Fly   405 SEYYAIPQR-----------GLSRLKKVSDKV----------KTQLSFVV-----PPMMRDLTKG 443
            :.:.|:.||           ..|.:::|.||:          :..||..|     ..::....||
Zfish   281 TNFSAVRQRINNTMNQPECMNCSSIQQVVDKLSLEGSLEFSDQNDLSSAVDKARNADVIGQANKG 345

  Fly   444 RTIFREHATNVRNIVEG-------VLSDI---------------------HIKTLHSTKS-FEDV 479
            |..|......|:|..:|       .|:||                     .|.||..:.| :...
Zfish   346 RDFFDSIPQKVKNETQGSVESALSKLNDIKGQISGVSKDLPLDFLKTIPKEISTLQQSVSVYSPE 410

  Fly   480 YERFGHDRNVVSLIVCLLILLVLFILIFALLCGCFG-RRRTGYGDECCSKSTGATCLLLAILLIF 543
            .||.......:.||:..|||||:......||.|..| ..:....|...:.:.|...|::.:...|
Zfish   411 VERASLISRAIGLILSCLILLVVVCNFLGLLLGAVGLNAKQSPTDRSGTSNCGGVFLMVGVGFSF 475

  Fly   544 CVFSFIALVGLFYFMLGMVTYQGACAPLRDQENNTLFRQLDASIDLNHYLPPSESNKEVVQPLKM 608
            .:.....||.|..|::...||...|.|.:.       :||...||....:|....:|.:  .||:
Zfish   476 LISWIFMLVVLILFIVVGNTYTLVCVPWQS-------KQLIQIIDTPGMIPGFNLSKNL--NLKI 531

  Fly   609 SSAI----KACHANQTIFDMMRQHNIYDINDLTRIKVMSHSQENTDSIKVFDEDLSTVVLLTKEE 669
            |..|    ..|..|..::..:..:.:.|:|..  :.|.:::||...|.:....:::.:.:|:.:.
Zfish   532 SLNIYDIYSNCEQNAPLWTTLHLNELVDLNKY--LNVSNYTQEIYQSFEAAQINIANITILSPDI 594

  Fly   670 RDELKTAGESKLAKYHSSLYMPSLCTQFTPMNLNALSEQL---------YKLSNDLEYPAYGWAK 725
            :.:|.....|......|::...  ....:..||::.::.|         ..:||.|    :|.||
Zfish   595 KSQLNNFSNSASTMNFSTIIQH--INDVSGTNLSSAADSLDFLAGKQSNQNISNQL----HGEAK 653

  Fly   726 VSFWNEGLNTKAFYRNFVPKLTSLVEKMKANLKKIDELISYENHDFTNTI-------KILTATAI 783
                    :.:....:....:..|:.::.:.:..:..:.|..|....|.:       :||.   .
Zfish   654 --------DLRDIQADITSNIMPLLLELNSTINNLSAVASQINASVQNVLQNVGYAQEILN---Y 707

  Fly   784 NSEQFIQTRGKDYINALGGNLTNSIDQM--IDDYIDMIIKEANESVGHCAPLSYIYYRGVDLICH 846
            |..|.::...|.:::.          ||  ...||....:....:||.|.|.:....|..:|:|.
Zfish   708 NISQIVRAESKVFVDC----------QMKIFLAYIQWANQTITGNVGRCRPAAAAIDRTENLLCK 762

  Fly   847 RIVDPINGFWVGILLCALLFLPILFVAHRLMCLYKKIYPYLATVGAAGVVEGGSDYLYDAYSE-R 910
            .:|..:|.||..:..|.|..:|.:.::.:|...|:::                      .||: .
Zfish   763 HLVGSLNAFWFSLGWCMLFLIPSIILSVKLAKYYRRM----------------------KYSDVY 805

  Fly   911 DREHVPLANVPKKRRK 926
            :..::|:...||...|
Zfish   806 ENNNLPMHPFPKANLK 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
promL	NP_001261351.1	Prominin	76..881	CDD:283200	180/878 (21%)
prom2	NP_001289158.1	Prominin	20..797	CDD:283200	180/878 (21%)
prom2	NP_001289158.1	mycoplas_twoTM	156..>296	CDD:275320	39/202 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46440
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	1	1.000	-	-		otm24618
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3755
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.850