DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment promL and prom1a

DIOPT Version :9

Sequence 1:	NP_001261351.1	Gene:	promL / 38372	FlyBaseID:	FBgn0026189	Length:	1013	Species:	Drosophila melanogaster
Sequence 2:	XP_021336643.1	Gene:	prom1a / 322857	ZFINID:	ZDB-GENE-030131-1577	Length:	902	Species:	Danio rerio

Alignment Length:	911	Identity:	194/911 - (21%)
Similarity:	354/911 - (38%)	Gaps:	182/911 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 AMNPIFNFTH-FLYDKVLYRDEPIPEGYIVVKNSD---TLSLGPKVEENDWRDLLAHYWMV--LI 168
            |:..:||..| ||:   :.:..|.||..::....|   .:....:..||....|...|:.:  ::
Zfish    55 AIGILFNMMHAFLF---VVQPNPFPEDLVISAAKDKFGAIQSEYQKPENIVLTLQVIYYELGFVV 116

  Fly   169 WVVILVVLIIVIPFIAVCYCCFCCCRRC------RQGCPPCTSKQDAQRRFCCGICLLILIIGLI 227
            ...:.::..:::|.:.:.:|...||..|      ||       :::|.   |....|..|::...
Zfish   117 CAALGLLFTVLLPLVGLLFCLCRCCDNCGGEMHQRQ-------RKNAD---CLRGLLTTLLLTTT 171

  Fly   228 F----GIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLKDVADHVHHLMMYNYEEMETHVLDQL 288
            |    |::.|:..|:.:.|........:|...:|..|:.......:.:|:. .|..::..||..|
Zfish   172 FIITAGVLCAYAANQNLSSQLKGMRRLVKSNLKDLHTFANQTPAQIDYLIS-RYGTVKEQVLHDL 235

  Fly   289 THA--------HRHIFLDLSDTSES-------------NSLAEMERVLENMPEALELMRQ-VEKM 331
            .:.        |..:..::....::             .::.:.:..|||:...||.::: ..|:
Zfish   236 ENVGVILGGRIHEELGKEVKPALDATLSMTGIKVEKAIKAMRDTKDALENVSLTLETLQEGTVKL 300

  Fly   332 EKDLRFYGSQLRDGVRGIKRD---VNFAVANLCQLQMCQKFLISSNIEHIDSSQCLHFDNLPNTK 393
            :.:|    |.:|:.:|....|   |:.....:|:                            |.:
Zfish   301 QANL----SVVRNSLRNALNDPVCVDAPAPEICR----------------------------NIR 333

  Fly   394 EFVEGMENIVASEYYAIPQRGLSRLKKVSDKVKTQLSFVVPPMMRDLTKGRTIFREHATNV---- 454
            ..:..:|  :|:.|.::|. ...:|.||:|.:||.||.:|       .||...|.:....|
Zfish   334 NSIPKLE--IAANYSSLPD-VTDQLNKVNDVLKTDLSQIV-------AKGIASFNDTPAMVTAQT 388

  Fly   455 RNIVEGV---LSDI------HIKTL--------------HSTKSFEDVY---ERFGHDRNVVSLI 493
            |||||||   |.||      ..|.|              |:....||:|   ::....|.:..:.
Zfish   389 RNIVEGVKVLLDDIGNNITSFSKMLPVHSSLANFTRMISHTHSQIEDIYPQIDQMDFYRWIGCIT 453

  Fly   494 VCLLILLVLFILIFALLCGCFGRRR----TGYGDECCSKSTGATCLLLAILLIFCVFSFIALVGL 554
            :|.:|:|:|......||||..|..|    |..|   |..:||...|:..:...| :||:: |:|:
Zfish   454 LCCMIVLILTFNFLGLLCGILGFDRHASPTTRG---CVSNTGGNFLMAGVGFSF-LFSWV-LMGV 513

  Fly   555 F--YFMLGMVTYQGACAPLRDQENNTLFRQLDASIDLN----HYLPPSESNKEVVQPLKMSSAIK 613
            .  .|:.|....:..|.|.:.::   ||:.||....:|    :::|....| :....|...|...
Zfish   514 ITALFLAGGNLEKLVCEPFQTRQ---LFKVLDTPYLVNSAWRNFIPGYLYN-DPEMDLTAYSLYS 574

  Fly   614 ACHANQTIFDMMRQHNIYDINDLTRIKVMSHS-QENTDSIKVFDEDLSTVVLLTKEERDELKTAG 677
            .|..|:.|:..:....|::|:......|.|.. ....:.:||   ||..::||..|.:..|....
Zfish   575 NCKDNRGIYSALHLDRIFNISSFFNTSVYSKDVSRKFEGLKV---DLRGIILLESEGKVNLNNFS 636

  Fly   678 ESKLAKYHSSLYMPSLCTQFTPMNL----NALSEQLYKLS-NDLEYPAYGWAKVSFWNEGLNT-- 735
            |:.:.:...:.|:..:....|.::|    |.|..|..:|| ..|:....|.|         ||
Zfish   637 ETGINEIDFAAYLEEVNKGVTRIDLIDFANQLDAQADQLSKGTLQTSLKGHA---------NTIR 692

  Fly   736 KAFYRNFVPKLTSL-VEKMKANLKKIDELISYENHDFTNTIKILTATAINSEQFIQTRGKDYINA 799
            :...:..||...|: ..|.::.|.:...|:...:.|....::.:.....:::..|.......||.
Zfish   693 QIHIQQVVPLEQSMKYVKARSTLNQSIRLLERTSSDLPLRVEDVLKAVDDAQNLISYNATFVINQ 757

  Fly   800 LGGNLTNSIDQMIDDYIDMIIKEANESVGHCAPLSYIYYRGVDLI----CHRIVDPINGFWVGIL 860
            .......:|......|||.|.......|..|.|||.|    ||.:    |..::|.:|.||.|:.
Zfish   758 ETEKYKQNIIGYFKQYIDWIRTSLALEVATCKPLSNI----VDTVEILGCGFLLDSMNTFWFGLG 818

  Fly   861 LCALLFLPILFVAHRLMCLYKK-----IYPYLATVGAAGVVEGGSDYLYDAYSERDREHVPLANV 920
            .|.|..||.:.::.:|...|::     :|..:.|.....:..|.:.| |:...|..:.|| :.::
Zfish   819 CCTLFLLPSIILSVKLAKFYRRMDTEDVYDDIETFPMKTMEIGYNGY-YNELLEGIQSHV-MESI 881

  Fly   921 P 921
            |
Zfish   882 P 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
promL	NP_001261351.1	Prominin	76..881	CDD:283200	184/864 (21%)
prom1a	XP_021336643.1	Prominin	50..839	CDD:310226	184/864 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596454
Domainoid	1	1.000	110	1.000	Domainoid score	I6244
eggNOG	1	0.900	-	-		E1_KOG4331
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4849
OMA	1	1.010	-	-		QHG46440
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	1	1.000	-	-		otm24618
orthoMCL	1	0.900	-	-		OOG6_105166
Panther	1	1.100	-	-	O	PTHR22730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3755
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800