Protein Alignment promL and Prom1

DIOPT Version :10

• Sequence 1: NP_647770.1
• Gene: promL / 38372
• FlyBaseID: FBgn0026189
• Length: 1013
• Species: Drosophila melanogaster
• Sequence 2: NP_001157049.1
• Gene: Prom1 / 19126
• MGIID: 1100886
• Length: 867
• Species: Mus musculus
• Alignment Length: 943
• Identity: 198/943 - (20%)
• Similarity: 360/943 - (38%)
• Gaps: 198/943 - (20%)

  Fly    82 GQP--HWPPVQYTVYRPTTNYTKAPPPPTSAMNPIFNFTHFLYDKVLYRDEPIP--EGYIVVKNS 142
            |||  |..|.......|||.|..........:.|::...|...:.|...|.|:.  :..|..||.
Mouse    21 GQPAFHNTPGAMNYELPTTKYETQDTFNAGIVGPLYKMVHIFLNVVQPNDFPLDLIKKLIQNKNF 85

  Fly   143 DTLSLGPKVEENDWRDL-LAHYWM-VLIWVVILVVLIIVIPFIAVCYCCFC-CCRRC------RQ 198
            | :|:..|..|.....| :|.|.: |||..::.::.||::|.:. |:.|.| ||.:|      ||
Mouse    86 D-ISVDSKEPEIIVLALKIALYEIGVLICAILGLLFIILMPLVG-CFFCMCRCCNKCGGEMHQRQ 148

  Fly   199 GCPPCTSKQDAQ-RRFCCGICLLILIIGLIFGIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYL 262
                   ||:|. ||.|.|:.||::.:.:..|||..||.|:...:....|.:..|....|..|.|
Mouse   149 -------KQNAPCRRKCLGLSLLVICLLMSLGIIYGFVANQQTRTRIKGTQKLAKSNFRDFQTLL 206

  Fly   263 KDVADHVHHLMMYNYEEMETHVLDQLTHAHRHIFLDLSDTSE----------------------- 304
            .:....:            .:|::|.|:.....|.||.....
Mouse   207 TETPKQI------------DYVVEQYTNTKNKAFSDLDGIGSVLGGRIKDQLKPKVTPVLEEIKA 259

  Fly   305 -SNSLAEMERVLENMPEALELMRQVEKMEKDLRFYGSQLRDGVRGIKRDV-NFAVANLCQLQMCQ 367
             :.::.:.:..|:||..:|          |.|:...:||...:..::..: |...::.|......
Mouse   260 MATAIKQTKDALQNMSSSL----------KSLQDAATQLNTNLSSVRNSIENSLSSSDCTSDPAS 314

  Fly   368 KFL--ISSNIEHIDSSQCLHFDNLPNTKEFVEGMENIVASEYYAIPQRGLSRLKKVSDKVKTQLS 430
            |..  |..::..:.||  |:...||:....:..:..:..::..::.:||.:.:.::.:.::.|..
Mouse   315 KICDSIRPSLSSLGSS--LNSSQLPSVDRELNTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTV 377

  Fly   431 FVVPPMMRDLTKGRTIFREHATNVRNIVEGVLSDIHIKTLHSTKSFEDVYERFGHDRN------- 488
            .|:                  .:|:|.::.:.|  :||.:..:...||:..:..|..|
Mouse   378 DVI------------------KDVKNTLDSISS--NIKDMSQSIPIEDMLLQVSHYLNNSNRYLN 422

  Fly   489 --------------VVSLIVCLLILLVLFILIFALLCGCFGRRR----TGYGDECCSKSTGATCL 535
                          :..||||.|:.|::......||||.||..:    |..|   |..:||...|
Mouse   423 QELPKLEEYDSYWWLGGLIVCFLLTLIVTFFFLGLLCGVFGYDKHATPTRRG---CVSNTGGIFL 484

  Fly   536 LLAI--LLIFCVFSFIALVGLFYFMLGMVTYQGACAPLRDQENNTLFRQLDASIDLNH----YLP 594
            :..:  ..:||....|.:|  ..|::|....:..|.|   .||..|.:.||....|..    ||.
Mouse   485 MAGVGFGFLFCWILMILVV--LTFVVGANVEKLLCEP---YENKKLLQVLDTPYLLKEQWQFYLS 544

  Fly   595 PSESNKEVVQPLKMSSAIKACHANQTIFDMMRQHNIYDINDLTRIKVMSHSQENTDS-IKVFDED 658
            ....|...:. :......:.|...:.|:...:..|:.:::|...|..:|   ||.:: ::..:.:
Mouse   545 GMLFNNPDIN-MTFEQVYRDCKRGRGIYAAFQLENVVNVSDHFNIDQIS---ENINTELENLNVN 605

  Fly   659 LSTVVLLTKEERDELKTAGESKLAKYHSSLYMPSLCTQFTPMNLNALSEQLYKLSNDLEYPAYGW 723
            :.::.||....|..|:....|.:.....|.|:.......|.:||...:..|...:|.|   ..|.
Mouse   606 IDSIELLDNTGRKSLEDFAHSGIDTIDYSTYLKETEKSPTEVNLLTFASTLEAKANQL---PEGK 667

  Fly   724 AKVSFWNEGLNTKAFYRNFVPKL------------------TSLVEKMKANLKKIDELISYENHD 770
            .|.:|..:..|.:|.:::.:|.:                  ..|.||:|..|..:|.:    .|.
Mouse   668 LKQAFLLDVQNIRAIHQHLLPPVQQSLNTLRQSVWTLQQTSNKLPEKVKKILASLDSV----QHF 728

  Fly   771 FTNTIKILTATAINSEQFIQTRGKDYINALGGNLTNSIDQMIDDYIDMIIKEANESVGHCAPLSY 835
            .||.:.::...  .:::|.:|       .||         ..:.|:..:.....|.:..|.|::.
Mouse   729 LTNNVSLIVIG--ETKKFGKT-------ILG---------YFEHYLHWVFYAITEKMTSCKPMAT 775

  Fly   836 IYYRGVD-LICHRIVDPINGFWVGILLCALLFLPILFVAHRLMCLYKK-----IYPYLATVGAAG 894
            .....|: ::|..:.||:|.||.||....:|.||.:.:|.:|...|::     :|..:.||....
Mouse   776 AMDSAVNGILCGYVADPLNLFWFGIGKATVLLLPAVIIAIKLAKYYRRMDSEDVYDDVETVPMKN 840

  Fly   895 VVEGGS----DYLYDAYSERDREHVPLANVPKK 923
            :..|.:    |:||..       |.|:...|.:
Mouse   841 LEIGSNGYHKDHLYGV-------HNPVMTSPSR 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
promL	NP_647770.1	Prominin	76..881	CDD:461660	187/890 (21%)
Prom1	NP_001157049.1	Prominin	19..822	CDD:461660	187/890 (21%)