Protein Alignment promL and prmn-1

DIOPT Version :10

• Sequence 1: NP_647770.1
• Gene: promL / 38372
• FlyBaseID: FBgn0026189
• Length: 1013
• Species: Drosophila melanogaster
• Sequence 2: NP_509907.1
• Gene: prmn-1 / 181330
• WormBaseID: WBGene00008571
• Length: 866
• Species: Caenorhabditis elegans
• Alignment Length: 908
• Identity: 195/908 - (21%)
• Similarity: 364/908 - (40%)
• Gaps: 215/908 - (23%)

  Fly   114 IFNFTHFLYDK-VLYRDEPIPEGYIV---VKNSDTLSLGPKVEENDWRDLLAHYWMVLI--WVVI 172
            :.:|.:...|: :.:...|.|...::   ....|.:.|...||:..|:      |:...  |:|:
 Worm    48 VLSFYYTTIDQFITFVSYPFPHQELLNDQALTGDLVELQSSVEKKYWQ------WIEFQKGWIVL 106

  Fly   173 LVVLIIVIPFIAVCY----CCFCCCRRCRQGCPPCTSKQDAQRRF--C----CGICLLILIIGLI 227
            .|.|:.:.....|.|    ||.|.|.|       .:.||:...|:  |    |.:.|.:|:....
 Worm   107 SVGLVAISVLFVVFYFFYKCCVCICSR-------SSKKQNTDARYDGCKRSMCNLLLFVLVSANA 164

  Fly   228 FGIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLKDVADHVHHLMMYNYEEMETHVLDQ----- 287
            |......:|::....|..:....|.:..:|..:|.:|....:..|::.:|:.:.:.:..|
 Worm   165 FVAFTLLMTSQYAQIGLDKLPNRMNQCVDDLQSYKRDSDMRIRKLLIDDYQVLNSTITKQLSTAG 229

  Fly   288 ---------LTHAH-RHIFLDLSDTSESNSLAEMERVLENMPEALELMRQVEKMEKDLRFYG--S 340
                     ||.|| ..:|:::|..::     ||...||::...:..:.     |:..||..  |
 Worm   230 YNVVDRVKKLTGAHVIDVFMNISKVAQ-----EMHDGLESVHGKVRFLN-----EEGSRFEAEFS 284

  Fly   341 QLRDG-----VRGIKRDVNFAVANLC-------------QLQMCQKFL-----------ISSNIE 376
            :||:.     |:.::.::. .|.::|             |.::.||||           :::||.
 Worm   285 RLRNTANEELVKCLENELE-PVRSMCAKAERLLESLAVTQFKIDQKFLPDATETGLSEIVNANIT 348

  Fly   377 HIDSSQCLHFDNLPNTKEFVEGMENIVASEYYAIPQRGLSRLKKVSDKVKTQLSFVVPPMMRDLT 441
            .:.::....|:.|.:.      :::.:..|.|:    ..:.||::.|.:     |:|
 Worm   349 QVLAASNNQFEQLESR------IQHEIDKETYS----AQNMLKQIGDDL-----FLV-------- 390

  Fly   442 KGRTIFREHATNVRNIVEGVLSDIHIKTLHSTKSFED--------VYERFGHDRNVVSLIVCLLI 498
             ..||    :|.:|.:.        .:.|:||.|:..        .|.::..   ..||::..|.
 Worm   391 -AETI----STQLRKVT--------FEALYSTVSYVSDPKKTPTLKYMQYSW---YASLVITSLF 439

  Fly   499 LLVLFILIFALLCGCFGRRRTGYGDECCSKSTGATCLLLAILLIFCVFSFIALVGLFYFMLGMVT 563
            :|:..|.:|.:|.|..|||.|.|.|:||.:|||.......|.....:|.|:| ||....|..:..
 Worm   440 ILLALIFLFGVLYGICGRRPTYYNDDCCVRSTGGKFYSFGIGAFLLIFVFLA-VGTSALMFAVGN 503

  Fly   564 YQG-ACAPLRDQENNTLFRQL-DASIDL---NHYLPPSESNKEVVQPLKMSSAIKACHANQTIFD 623
            :.. .|.|:|:..::.....| |..|:|   ||  .|....:..:|....:..|:||..|:|:::
 Worm   504 FSNLVCQPMRNPLSHPESLSLADRYINLWKANH--TPENDIEVTLQSKSPAEIIRACSRNETLYN 566

  Fly   624 MMRQHNIYDINDLTRIKVMSHSQ---------ENTDSIKVFDEDLSTVVLLTKEERDELKTAGES 679
            .......|.:|.|...:..:::|         ||...|:..|..:|         |.||:..  .
 Worm   567 FYGFDKKYHLNKLQDFEKDAYNQLQISLRTTMENMPEIRPLDAFIS---------RSELRDL--E 620

  Fly   680 KLAKYHSSLYMPSLCTQFTPMNLNALSEQLYKLSNDLEYPAYGWAKVSFWNEGLNT--------- 735
            |||..:.|        :.:...|||:...:.:|  ||.      :|...:.|.|:.
 Worm   621 KLASVNVS--------KVSQQGLNAIKHAMDEL--DLA------SKTREFEESLDANSGRPKAVT 669

  Fly   736 ------KAFYRNFVPKLTSLVEKMKANLKKIDELISYENHDFTN-TIKILTATAINSEQFIQTRG 793
                  :.....|...|.|.:|.:.:|:..:||.:|......:: .:|:..|.|:.:|...:..|
 Worm   670 LVLEQIRELEIQFAKPLRSRLEALYSNITSLDEKLSQLQVPVSSLLVKLQHAQALLAENMREHFG 734

  Fly   794 ---KDYINALGGNLTNSIDQMIDDYIDMIIKEANESVGHCAPLSYIYYRGVDLICHRIVDPINGF 855
               |:...    .:.|:|||    ||..:..:....|..|.||:.|..:....:|...:||.||.
 Worm   735 RAAKEEFQ----QMVNNIDQ----YIVHVKSQMESEVTSCQPLTQIARQTTAAVCAYTIDPYNGT 791

  Fly   856 WVGILLCALLFLPILFVAHRLMCLYKKIYPYLATVGAAGVVEGGSD------YLYDAYSERDR 912
            |:.:|:|.:|.:||:.:::.|:.||.|::.:     ...:||..|:      ::.|.|..|.:
 Worm   792 WMCMLICLVLLIPIVIISNSLIGLYSKMHAF-----PKYIVEPPSETHHMSSFITDTYDTRPK 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
promL	NP_647770.1	Prominin	76..881	CDD:461660	187/869 (22%)
prmn-1	NP_509907.1	Prominin	14..816	CDD:461660	186/868 (21%)