Protein Alignment promL and M28.8

DIOPT Version :10

• Sequence 1: NP_647770.1
• Gene: promL / 38372
• FlyBaseID: FBgn0026189
• Length: 1013
• Species: Drosophila melanogaster
• Sequence 2: NP_496294.1
• Gene: M28.8 / 174641
• WormBaseID: WBGene00010899
• Length: 831
• Species: Caenorhabditis elegans
• Alignment Length: 921
• Identity: 167/921 - (18%)
• Similarity: 298/921 - (32%)
• Gaps: 340/921 - (36%)

  Fly    96 PTTNYTKAPPPPTSAMNPIFNFTHFLYDKVLYRDEPIPEGYIVVKNSDTLSLGPKVEENDWRDL- 159
            |..|.|   .|...:|.|.|..::..||..    :.|.:|.....||.|.        :|..||
 Worm    24 PQCNQT---TPQIKSMKPNFGASNAFYDIA----KGISDGLQNTPNSKTY--------DDLNDLI 73

  Fly   160 ----------------LAHYWMVLIWVVILVVLIIVIPF-IAVCYCCFCCCRRCRQGCPPCTSKQ 207
                            :.....::.|.|..|.::..:.| :|.|..         |.|..|..|:
 Worm    74 FGNGAVSYNQVIQDMVINQIGAIIFWSVGFVFVLAALVFGVATCIW---------QICFSCVPKE 129

  Fly   208 DAQRRFCCGIC---LLILIIG------LIFGIIIAFVTNKMIDSGFAETSETMKRGSEDTCTYLK 263
            .:.|....|..   ||:.:..      :||.:....:|:. ||:|....::|    :.|..|.:.
 Worm   130 TSTRSEITGYVYAGLLVTVFAFTLTGLIIFNVAETDLTDS-IDNGMVYINQT----ASDLNTVIN 189

  Fly   264 DVADHVH--------------HLMMYNY--------------------EEMETHVLDQLTHAHRH 294
            |..|.|.              :|.:.||                    |.....:.:..|....:
 Worm   190 DGTDQVTCEVTTTTTQTFGNVNLFISNYSAIVVGGTATEVGLTAVNAFEYRNFQIQNNATIDAAN 254

  Fly   295 IFL----------DLSDTSES-------------NSLAEMERVLENMPEALELMRQVEKMEKDLR 336
            |.|          |...|.:|             |:|:...:.:...||.:.|..|::.::|:::
 Worm   255 ILLTSMDNINTNGDACTTDKSVLQQQIEIMIPTLNALSSGAQTVHTSPEIIALNDQIDLLKKNIQ 319

  Fly   337 FYGSQLRDGVRGIKRDVNFAVANLCQLQMCQKFLISSNIEHIDSSQCLHFDNLPNTKEFVEGMEN 401
            .........:...:..:|.|:.::..:        ..|:::       ..:|:.|:  ......:
 Worm   320 TQADSASGSINSTQGTINDAMTSIRNM--------LGNVQN-------DLNNVMNS--LASAHRD 367

  Fly   402 IVASEYYAIPQRGLSRLKKVSDKVKTQLSFVVPPMMRDLTKGRTIFREHATNVRNIVEGVLSDIH 466
            :|.|..|:    ||        |:..:|...:|
 Worm   368 VVTSSAYS----GL--------KIGIRLLITIP-------------------------------- 388

  Fly   467 IKTLHSTKSFEDVYERFGHDRNVVSLIVCLLILLVLFILIFALLCGCFGRRRTGYGDECCSKSTG 531
                                    :.|.||..:|....::.:||                 |...
 Worm   389 ------------------------ACIGCLFCILAFVAVVLSLL-----------------KKEN 412

  Fly   532 ATCLLLAILLIFCVFSFIALVGLFY----FMLGMVTYQGACAPLRDQENNTLFRQLDASIDLNHY 592
            ...|..|:|:.|.:...|::|.:.:    |:||.:| ..||.|:.:..|.||||.::.:|
 Worm   413 VEFLATAVLVAFYLTILISIVLILFSSAAFVLGWLT-SAACVPIFEDNNYTLFRLMNQTI----- 471

  Fly   593 LPPSESNKEVVQPLKMSSAIKACH----------ANQTIF---DMMRQHNIYDINDLTRIKVMS- 643
            .|....:.:.|   .:...:::|:          ..|||.   .:.:|.|:....|....::||
 Worm   472 APVGTGSPDTV---NIGQLLQSCNNPSMTLYTAVDGQTIISADSINQQINLASYRDAANNEIMSQ 533

  Fly   644 -HSQENTDSIKVFDED-LSTVVLLTKEERDELKTAGESKLAKYHSSLYMPSLCTQFTPMNLNALS 706
             :|....|:..:.|.: |:.:|          ..|.|:.|          |:|
 Worm   534 PNSTYTIDNSYLTDSNSLNQIV----------NAANEANL----------SVC------------ 566

  Fly   707 EQLYKLSNDLEYPAYGWAKVSFWNEGLNTKAFYRNFVPKLTSLVEKMKANLKKIDELISYENHDF 771
                  .||                  :..|.|::::.||.            :.:.:|   :.|
 Worm   567 ------GND------------------DATAKYKDYIQKLA------------VSDALS---NQF 592

  Fly   772 TNTIKILTATAINSEQFIQTRGKDYINALGGNLTNSIDQMIDDYIDMIIKEANESVGHCAPLSYI 836
            ...::.|.|.|.|:....:.:..:|.|.  |:|  ||:|.|.|    :|.....:|..|.|...:
 Worm   593 ITNLQTLAANAPNTTSIAKNQNNNYFNQ--GDL--SINQSISD----LIINLQTNVFMCRPFVDV 649

  Fly   837 YYRGVDLICHRIVDPINGFWVGILLCALLFLPILFVAHRLMCLYKKIYPYLATVGAAGVVEGGSD 901
            |..|..::|.:...||.|.|..:.|..|    .||....|:.|   :|.:|.|         .||
 Worm   650 YNNGGFVMCEQFGKPIQGLWAAVGLTGL----FLFFQSILLLL---VYRWLRT---------NSD 698

  Fly   902 YLYDAYSERDR 912
            .| ..|:.||:
 Worm   699 DL-AMYNYRDK 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
promL	NP_647770.1	Prominin	76..881	CDD:461660	158/888 (18%)
M28.8	NP_496294.1	Prominin	<328..679	CDD:461660	94/544 (17%)