DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45067 and M28.4

DIOPT Version :9

Sequence 1:	NP_001334707.1	Gene:	CG45067 / 38371	FlyBaseID:	FBgn0266437	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001364586.1	Gene:	M28.4 / 353403	WormBaseID:	WBGene00010895	Length:	775	Species:	Caenorhabditis elegans

Alignment Length:	820	Identity:	161/820 - (19%)
Similarity:	275/820 - (33%)	Gaps:	274/820 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GSKVQEDDWEAYLASQKGLKI---LVLLLVLLFLLILILGLLYAC--CCVAWEKNERSSRGCRYC 159
            |:....|.:...:|.|.|..|   |..:||.:.|.:.|:..::.|  .| |.:||...|:    .
Worm    77 GTVTLNDVFADLVAGQPGPTIFWKLGFILVFVTLALCIVTAIWLCFYSC-APKKNSSDSK----I 136

  Fly   160 CGILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKASERLRHLYVI 224
            .||:.|  .||::.|.| |:......|....:|       .:|...:.||:.|.||:|.:.|...
Worm   137 TGIVYA--GLLVITFAI-ALNGLILFNTAESDL-------VDSIDKTMDYVKQIASDRTKVLTEG 191

  Fly   225 NYDQKVKRIKSALNQDPSIKYPNRELEVHAKAIERLIEVLRNMRRIKPVMLRIKNRLLDARRLAT 289
            .|.                           .|.|.|.....|...:...:....:.::|
Worm   192 AYQ---------------------------VACEFLRTTSHNFAHLNSFVSNYTSTVVD------ 223

  Fly   290 QFRDALRGVKRDLMVILIADCTHSECQDFYRANEIKM---------------LDMGC-LHYDSLP 338
               |...||.       |.|....:...:...|:|.:               |||.| .|..:|.
Worm   224 ---DTESGVG-------IVDVNDFDLSGYRDQNQITIKSGNALVNRLRNMNTLDMDCKAHAKNLV 278

  Fly   339 EFEPLLESVQEVIDSKFIDYPLQAVG--------QLRRMSSAIKNRMSDILDSVNKDLN---KGA 392
            :..|:||..          .|:.|..        ||:|::|.||    ||.|.:..:.|   |..
Worm   279 KEIPVLEKT----------LPVSAAATRIIKGSMQLQRINSQIK----DIKDHIQTESNRALKAI 329

  Fly   393 KKLQERYEASLKVLRQVVEEMKKDMPLVVKTNPRSRSTPAADLRRKLGSSWFGTTLCLIVLLMLV 457
            |:.|:..:.|||.:...:...::::       ..:.||..:.....:.||.:.:....:.||:.:
Worm   330 KQAQKIVDGSLKTINTSLIAYQQEV-------TEALSTLNSGHEHFVASSGYSSLKICVRLLVTL 387

  Fly   458 PLLLLFGLLIALFS----------------------PKVASWLLCAVLVALFILFSVGVILVLF- 499
            |:.:  ||:..:..                      ||:|:    .|||..::...|.::|:||
Worm   388 PICI--GLVFCIIGCVAIALSLWKNTPSKFTLPTQFPKLAT----IVLVGFYVSIVVSIVLLLFS 446

  Fly   500 --YLVHGALIYQAFCSRKFPQPVDN--------KSIN----PNKFLPENV----TTFRSMPMVRT 546
              ..:.|..: .|.|...|..  ||        .|||    |..:|  |:    |:.|:..|.
Worm   447 STLFILGWFV-SAICVPTFQD--DNYTMFHSIHVSINRTNGPLDYL--NIGKLFTSCRNPRMT-- 504

  Fly   547 SEILQSCVRNESLYNVLGIKEIYDPYGFRDDVMIDVVKSLEKMGNTSMPGAPKEIHPDAEESAKK 611
               |.|.:..|.|:.:..:.|..:...||:.....::|         :|..........|.|..|
Worm   505 ---LYSAIEGEKLFRLESVTEKLNLNAFRNMTNEKIMK---------LPNLTFSFEKHHEISFDK 557

  Fly   612 LLTG-------NLSTYD----IKDYTKYICPQLVPEPNPGPLDGLTRKLESLANK-VEPGVTLKN 664
            :..|       ||:..|    :::|.:||              .|..|..||::: |:...||.:
Worm   558 ISHGYSTVKKSNLTDCDDEDAVQEYQEYI--------------ELLEKSYSLSDQFVDIVKTLSS 608

  Fly   665 QAIHLRAYQKHLCVPLAAIVQRLIKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKK 729
            .|:::                .||.|....|:..||.:
Worm   609 NALNM----------------TLIARDLNNDYFDSGDW--------------------------- 630

  Fly   730 EADEVARNISKLVKSGLDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADLCNRIAKPMNAIW- 793
                           .:::.:..:....:.::..|.|.|...:...:   .||.::.||::.:|
Worm   631 ---------------SINESITALRTNLQTNIFMCRPFIDIFNNGGI---ILCQQLGKPIHGMWA 677

  Fly   794 ------FWLLLFSSLLLPTICCTHFLRSRLNSLKHSVATP 827
                  ...||.|.|.|   ....:||......|.|.|.|
Worm   678 SAGLAGIAFLLQSILFL---LVYRWLRQSDVDKKDSTAVP 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	None
M28.4	NP_001364586.1	Prominin	101..693	CDD:398888	147/770 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010