DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45067 and prom1a

DIOPT Version :9

Sequence 1:	NP_001334707.1	Gene:	CG45067 / 38371	FlyBaseID:	FBgn0266437	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_021336643.1	Gene:	prom1a / 322857	ZFINID:	ZDB-GENE-030131-1577	Length:	902	Species:	Danio rerio

Alignment Length:	794	Identity:	167/794 - (21%)
Similarity:	304/794 - (38%)	Gaps:	181/794 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 GLKILVLLLVLLFLLILILGLLYA-C-CC--VAWEKNERSSRGCRYCCGILLAILALLMLLFLIL 177
            |..:...|.:|..:|:.::|||:. | ||  ...|.::|..:......|:|..:  ||...|:|.
Zfish   113 GFVVCAALGLLFTVLLPLVGLLFCLCRCCDNCGGEMHQRQRKNADCLRGLLTTL--LLTTTFIIT 175

  Fly   178 A-IMAATQLNINL------------KNLKASGCYPSNSSQSSADYIFQK---ASERLRH----LY 222
            | ::.|...|.||            .|||....: :|.:.:..||:..:   ..|::.|    :.
Zfish   176 AGVLCAYAANQNLSSQLKGMRRLVKSNLKDLHTF-ANQTPAQIDYLISRYGTVKEQVLHDLENVG 239

  Fly   223 VI----NYDQKVKRIKSALNQDPSIKYPNRELEVHAKAIERLIEVLRN----MRRIKPVMLRIKN 279
            ||    .:::..|.:|.||  |.::.....::|...||:....:.|.|    :..::...::::.
Zfish   240 VILGGRIHEELGKEVKPAL--DATLSMTGIKVEKAIKAMRDTKDALENVSLTLETLQEGTVKLQA 302

  Fly   280 RLLDARRLATQFRDALRGVKRDLMVILIADCTHSECQDFYR--ANEIKMLDMGCLHYDSLPEFEP 342
            .|       :..|::||....|.:      |..:...:..|  .|.|..|::.. :|.|||:...
Zfish   303 NL-------SVVRNSLRNALNDPV------CVDAPAPEICRNIRNSIPKLEIAA-NYSSLPDVTD 353

  Fly   343 LLESVQEVID-----------SKFIDYPLQAVGQLRRMSSAIKNRMSDILDSVNKDLNKGAKKLQ 396
            .|..|.:|:.           :.|.|.|.....|.|.:...:|    .:||.:..::...:|.|.
Zfish   354 QLNKVNDVLKTDLSQIVAKGIASFNDTPAMVTAQTRNIVEGVK----VLLDDIGNNITSFSKMLP 414

  Fly   397 ERYEASL----KVLRQVVEEMKKDMPLVVKTNPRSRSTPAADLRRKLGSSWFG--TTLCLIVLLM 455
              ..:||    :::.....:::...|.:          ...|..|     |.|  |..|:|||::
Zfish   415 --VHSSLANFTRMISHTHSQIEDIYPQI----------DQMDFYR-----WIGCITLCCMIVLIL 462

  Fly   456 LVPLLLLFGLLIALF------SPKV--------ASWLLCAVLVALFILFS---VGVILVLFYLVH 503
            ....|   |||..:.      ||..        .::|:..  |....|||   :|||..|| |..
Zfish   463 TFNFL---GLLCGILGFDRHASPTTRGCVSNTGGNFLMAG--VGFSFLFSWVLMGVITALF-LAG 521

  Fly   504 G---ALIYQAFCSRKFPQPVDNK-SINP--NKFLPENVTTFRSMPMVRTSEILQSCVRNESLYNV 562
            |   .|:.:.|.:|:..:.:|.. .:|.  ..|:|..:.....|.:...| :..:|..|..:|:.
Zfish   522 GNLEKLVCEPFQTRQLFKVLDTPYLVNSAWRNFIPGYLYNDPEMDLTAYS-LYSNCKDNRGIYSA 585

  Fly   563 LGIKEIYDPYGFRDDVMIDVVKSLEKMGNTSMPGAPKEIHPDAE------------ESAKKLLTG 615
            |.:..|:               ::....|||:  ..|::....|            ||..|:...
Zfish   586 LHLDRIF---------------NISSFFNTSV--YSKDVSRKFEGLKVDLRGIILLESEGKVNLN 633

  Fly   616 NLSTYDIK--DYTKYICPQLVPEPNPG----PLDGLTRKLESLANKVEPG---VTLKNQAIHLRA 671
            |.|...|.  |:..|:     .|.|.|    .|.....:|::.|:::..|   .:||..|..:|.
Zfish   634 NFSETGINEIDFAAYL-----EEVNKGVTRIDLIDFANQLDAQADQLSKGTLQTSLKGHANTIRQ 693

  Fly   672 YQKHLCVPLAAIVQRLIKR--LKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDS----KKE 730
            ......|||...::.:..|  |.|...||..........:..:|..:....:|:..::    .:|
Zfish   694 IHIQQVVPLEQSMKYVKARSTLNQSIRLLERTSSDLPLRVEDVLKAVDDAQNLISYNATFVINQE 758

  Fly   731 ADEVARNISKLVKSGLDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADL--CNRIAKPMNAIW 793
            .::..:||....|    .|:..:..:...::.:|:||     ..:|:..::  |..:...||..|
Zfish   759 TEKYKQNIIGYFK----QYIDWIRTSLALEVATCKPL-----SNIVDTVEILGCGFLLDSMNTFW 814

  Fly   794 FWLLLFSSLLLPTI 807
            |.|...:..|||:|
Zfish   815 FGLGCCTLFLLPSI 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	None
prom1a	XP_021336643.1	Prominin	50..839	CDD:310226	167/794 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596457
Domainoid	1	1.000	110	1.000	Domainoid score	I6244
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4849
OMA	1	1.010	-	-		QHG46440
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22730
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.010