Protein Alignment CG45067 and Prom2

DIOPT Version :10

• Sequence 1: NP_001334707.1
• Gene: CG45067 / 38371
• FlyBaseID: FBgn0266437
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_620089.2
• Gene: Prom2 / 192212
• MGIID: 2138997
• Length: 835
• Species: Mus musculus
• Alignment Length: 873
• Identity: 184/873 - (21%)
• Similarity: 330/873 - (37%)
• Gaps: 173/873 - (19%)

  Fly    35 DQGSLVRFRRLS----PQNRYAEPESRSNNGDADSMCPITYLSHVFTGSVVSYAKEV-----PKG 90
            |.|||.|...|:    |:.|...|..|::.       |:..|    .|:|..:...|     |..
Mouse    29 DCGSLGRVEHLAFARVPRTRELAPLVRASG-------PLNSL----YGTVRRFLSVVQLNPFPAE 82

  Fly    91 YISKDGNDIGSKVQEDDWEAYLASQKGLKILVLLLVLLFLLILILGLLYACC-----CVAWEKNE 150
            .|....|| .|.|:.|:...|   :.|..:..::..|..||:.|.||.:.||     |....|.|
Mouse    83 LIKTLLND-PSSVKTDEVVRY---EAGYVVCAVIAGLYLLLVPITGLCFCCCRCRQRCGGRVKTE 143

  Fly   151 RSSRGCRYCCGILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKAS 215
            ..:..|..  |.|: |..||..|.|::.::.|...|.:..:...........:..|...:.....
Mouse   144 HKAMACER--GTLM-IFLLLTTLVLLIGMVCAFATNQHTHSQTGPSVKAVPETLLSLRGLVSDVP 205

  Fly   216 ERLRHLYVINYDQKVKRIKSAL------------NQDPSIKYP--------NRELEV---HAKAI 257
            |.||.: ...:....|::...|            |:..|..||        .:.|:|   |.:|:
Mouse   206 EELRAI-AEQFSVPQKQVSKELDGVGENLGNVIHNRLKSTVYPVLASVHSLGQALQVSIDHLRAL 269

  Fly   258 ERL-IEVLRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVKRDLMVILIAD--CTHSECQDFY 319
            ... :|:....|.::|.:...:.|||                      .|:.|  |....|:..
Mouse   270 NTTSVELQEAQRHLEPPVQAHRERLL----------------------ALLQDSWCHEENCKRV- 311

  Fly   320 RANEIKMLDMGCLHYDSLPEFEPLLESVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSV 384
             .::...|.:|. .:...|..:.:|..:::|.::.|.....:.......:...::.:...::..|
Mouse   312 -LSQAGALQLGA-DFSQTPPVDDVLHRLKDVPETNFSSMVQEEKATFNNLPLLVQVQAVSVVKDV 374

  Fly   385 NKDL---NKGAKKLQERYEASLKVLR--QVVEEMKKDMPLVVKTNPRSRSTP-AADLRRKLGSSW 443
            .|.|   .:|.:.|.:.:..|....|  |.:|.:::            ||.| ..::::.....|
Mouse   375 KKALAEQPEGLRMLAQAFPGSEAASRWSQALEGLEQ------------RSRPYLQEVQQYETYRW 427

  Fly   444 -FGTTLCLIVLLMLVPLLLLFGL----LIALFSP-------KVASWLLCAVLVALFILFSVGVIL 496
             .|..||..:||:::..||...|    |.|...|       :..:.||.|. ||...||:|.:||
Mouse   428 ILGCVLCSAILLVVICNLLGLSLGIWGLFAREDPSHSETKGEAGARLLMAG-VAFSFLFAVPLIL 491

  Fly   497 VLF--YLVHG---ALIYQAFCSRKFPQPVDNKSINPNKFLPENVTTFRSMPMVRTSEILQS---C 553
            ::|  :||.|   .|:.:::.|.:..:..|    .|.. ||.::.....:.:.:...|:|:   |
Mouse   492 LVFVTFLVGGNVQTLVCRSWESGELYEFAD----TPGN-LPPSMNLSYLLGLKKNISIVQAYRQC 551

  Fly   554 VRNESLYNVLGIKEIYDPYGFRDDVMIDVVKSLEKMGN--TSMPGAPKE---IHPDAEESAKKLL 613
            .....|:.||.:.:.||.     |..:|:.:...|:..  .|.....||   :.|.|.:..:.|.
Mouse   552 KAGAVLWKVLQLNDSYDL-----DKHLDIKQYTHKIQQELQSFQVDLKELDLLSPTARQDLEALQ 611

  Fly   614 TGNLSTYDIKDYTKYICPQLVPEPNPGPLDGLTRKLESLANKVEPGV---TLKNQAIHLRAYQKH 675
            ...|.....:.:...|...:|..    .:..|.::||.||......:   .|:.:|..||:..:.
Mouse   612 RSGLEKIHYRGFLVQIQKPVVNT----DMWQLAQELEGLAQAQNDSLLRQQLREEARELRSLYQE 672

  Fly   676 LCVPLAAIVQRL---IKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEVARN 737
            ..||..::|.:|   :|.|:.:...|......|       ||.:.:    |:.:...:.:.:.||
Mouse   673 KVVPQESLVTKLNFSVKTLESLAPSLQVNTSDF-------LDSVTR----LKGELPVQINHILRN 726

  Fly   738 ISKLVKSG----LDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADLCNRIAKPMNAIWFWLLL 798
            .::...:.    ...||..|.....:.:.:|:|.....|..   :..||:.:|.|.||.||.|..
Mouse   727 ATECFLTREMGYFSQYVTWVRAEVTQRIATCQPFSTALDNG---HVILCDMMADPWNAFWFCLGW 788

  Fly   799 FSSLLLPTI-----CCTHF--LRSRLNS 819
            .:..|:|:|     ...:|  :|.||:|
Mouse   789 CTFFLIPSIIFAVKTSKYFRPIRKRLSS 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	Prominin	<215..791	CDD:461660	125/642 (19%)
Prom2	NP_620089.2	Prominin	29..808	CDD:461660	179/863 (21%)