DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45067 and Prom2

DIOPT Version :9

Sequence 1:	NP_001334707.1	Gene:	CG45067 / 38371	FlyBaseID:	FBgn0266437	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_620089.2	Gene:	Prom2 / 192212	MGIID:	2138997	Length:	835	Species:	Mus musculus

Alignment Length:	873	Identity:	184/873 - (21%)
Similarity:	330/873 - (37%)	Gaps:	173/873 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DQGSLVRFRRLS----PQNRYAEPESRSNNGDADSMCPITYLSHVFTGSVVSYAKEV-----PKG 90
            |.|||.|...|:    |:.|...|..|::.       |:..|    .|:|..:...|     |..
Mouse    29 DCGSLGRVEHLAFARVPRTRELAPLVRASG-------PLNSL----YGTVRRFLSVVQLNPFPAE 82

  Fly    91 YISKDGNDIGSKVQEDDWEAYLASQKGLKILVLLLVLLFLLILILGLLYACC-----CVAWEKNE 150
            .|....|| .|.|:.|:...|   :.|..:..::..|..||:.|.||.:.||     |....|.|
Mouse    83 LIKTLLND-PSSVKTDEVVRY---EAGYVVCAVIAGLYLLLVPITGLCFCCCRCRQRCGGRVKTE 143

  Fly   151 RSSRGCRYCCGILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKAS 215
            ..:..|..  |.|: |..||..|.|::.::.|...|.:..:...........:..|...:.....
Mouse   144 HKAMACER--GTLM-IFLLLTTLVLLIGMVCAFATNQHTHSQTGPSVKAVPETLLSLRGLVSDVP 205

  Fly   216 ERLRHLYVINYDQKVKRIKSAL------------NQDPSIKYP--------NRELEV---HAKAI 257
            |.||.: ...:....|::...|            |:..|..||        .:.|:|   |.:|:
Mouse   206 EELRAI-AEQFSVPQKQVSKELDGVGENLGNVIHNRLKSTVYPVLASVHSLGQALQVSIDHLRAL 269

  Fly   258 ERL-IEVLRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVKRDLMVILIAD--CTHSECQDFY 319
            ... :|:....|.::|.:...:.|||                      .|:.|  |....|:..
Mouse   270 NTTSVELQEAQRHLEPPVQAHRERLL----------------------ALLQDSWCHEENCKRV- 311

  Fly   320 RANEIKMLDMGCLHYDSLPEFEPLLESVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSV 384
             .::...|.:|. .:...|..:.:|..:::|.::.|.....:.......:...::.:...::..|
Mouse   312 -LSQAGALQLGA-DFSQTPPVDDVLHRLKDVPETNFSSMVQEEKATFNNLPLLVQVQAVSVVKDV 374

  Fly   385 NKDL---NKGAKKLQERYEASLKVLR--QVVEEMKKDMPLVVKTNPRSRSTP-AADLRRKLGSSW 443
            .|.|   .:|.:.|.:.:..|....|  |.:|.:::            ||.| ..::::.....|
Mouse   375 KKALAEQPEGLRMLAQAFPGSEAASRWSQALEGLEQ------------RSRPYLQEVQQYETYRW 427

  Fly   444 -FGTTLCLIVLLMLVPLLLLFGL----LIALFSP-------KVASWLLCAVLVALFILFSVGVIL 496
             .|..||..:||:::..||...|    |.|...|       :..:.||.|. ||...||:|.:||
Mouse   428 ILGCVLCSAILLVVICNLLGLSLGIWGLFAREDPSHSETKGEAGARLLMAG-VAFSFLFAVPLIL 491

  Fly   497 VLF--YLVHG---ALIYQAFCSRKFPQPVDNKSINPNKFLPENVTTFRSMPMVRTSEILQS---C 553
            ::|  :||.|   .|:.:::.|.:..:..|    .|.. ||.::.....:.:.:...|:|:   |
Mouse   492 LVFVTFLVGGNVQTLVCRSWESGELYEFAD----TPGN-LPPSMNLSYLLGLKKNISIVQAYRQC 551

  Fly   554 VRNESLYNVLGIKEIYDPYGFRDDVMIDVVKSLEKMGN--TSMPGAPKE---IHPDAEESAKKLL 613
            .....|:.||.:.:.||.     |..:|:.:...|:..  .|.....||   :.|.|.:..:.|.
Mouse   552 KAGAVLWKVLQLNDSYDL-----DKHLDIKQYTHKIQQELQSFQVDLKELDLLSPTARQDLEALQ 611

  Fly   614 TGNLSTYDIKDYTKYICPQLVPEPNPGPLDGLTRKLESLANKVEPGV---TLKNQAIHLRAYQKH 675
            ...|.....:.:...|...:|..    .:..|.::||.||......:   .|:.:|..||:..:.
Mouse   612 RSGLEKIHYRGFLVQIQKPVVNT----DMWQLAQELEGLAQAQNDSLLRQQLREEARELRSLYQE 672

  Fly   676 LCVPLAAIVQRL---IKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEVARN 737
            ..||..::|.:|   :|.|:.:...|......|       ||.:.:    |:.:...:.:.:.||
Mouse   673 KVVPQESLVTKLNFSVKTLESLAPSLQVNTSDF-------LDSVTR----LKGELPVQINHILRN 726

  Fly   738 ISKLVKSG----LDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADLCNRIAKPMNAIWFWLLL 798
            .::...:.    ...||..|.....:.:.:|:|.....|..   :..||:.:|.|.||.||.|..
Mouse   727 ATECFLTREMGYFSQYVTWVRAEVTQRIATCQPFSTALDNG---HVILCDMMADPWNAFWFCLGW 788

  Fly   799 FSSLLLPTI-----CCTHF--LRSRLNS 819
            .:..|:|:|     ...:|  :|.||:|
Mouse   789 CTFFLIPSIIFAVKTSKYFRPIRKRLSS 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	None
Prom2	NP_620089.2	Prominin	29..808	CDD:283200	179/863 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850504
Domainoid	1	1.000	129	1.000	Domainoid score	I5224
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4594
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46440
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22730
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090