DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45067 and Prom2

DIOPT Version :9

Sequence 1:	NP_001334707.1	Gene:	CG45067 / 38371	FlyBaseID:	FBgn0266437	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_620212.2	Gene:	Prom2 / 192211	RGDID:	621435	Length:	834	Species:	Rattus norvegicus

Alignment Length:	799	Identity:	167/799 - (20%)
Similarity:	310/799 - (38%)	Gaps:	155/799 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SKVQEDDWEAYLASQKGLKILVLLLVLLFLLILILGLLYACC-----CVAWEKNERSSRGCRYCC 160
            |.|:.|:...|   :.|..:..::..|..||:.|.||.:.||     |....|.|..:..|..
  Rat    92 SSVKTDEVVRY---EAGYVVCAVIAGLYLLLVPITGLCFCCCRCRRRCGGRVKTEHKAMACER-- 151

  Fly   161 GILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKASERLRHLYVIN 225
            |.|:..| ||..|.|::.::.|...|              ..:.|......:...|.|..|..:.
  Rat   152 GTLMTFL-LLTTLMLLIGMVCAFATN--------------QFTHSQTGPSVEAVPETLLSLRGLV 201

  Fly   226 YDQKVKRIKSALNQDPSIKYPNRELEVHAKAI-ERLIEVLRNMRR--IKPVMLRIK--------- 278
            .|.. |::::..:|   ...|.:::......: |.|..::.|..:  :.||:..:.
  Rat   202 SDVP-KKLQAVADQ---FSLPQKQVSKDLDGVGENLGNIIHNQLKSTVYPVLASVHGLGQALQVS 262

  Fly   279 -NRLLDARRLATQFRDA-------LRGVKRDLMVILIADCTHSECQDFYRANEIKMLDMGCLHYD 335
             :.|......:.:.|:.       ::..:..|:.:|.....|..|:.  ..::...|.:|. .:.
  Rat   263 IDHLQSVNATSVELREGQQHLGPPVQAHRERLLALLQESWCHENCKG--ALSQASALQLGA-DFS 324

  Fly   336 SLPEFEPLLESVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSVNKDLNK-------GAK 393
            .:|..:.:|..:|.|.::.|.....:.......:...:..:|.    ||.|||.|       |.:
  Rat   325 QMPPVDDVLHRLQGVPEANFSSMVQEENATFNNLPILVHMQMV----SVVKDLKKALAEQPEGVR 385

  Fly   394 KLQERYEASLKVLR--QVVEEMKKDMPLVVKTNPRSRSTP-AADLRRKLGSSW-FGTTLCLIVLL 454
            .|.:.:..|....|  |.:|.:::            ||.| ..|::|.....| .|..||..:||
  Rat   386 MLAQAFPGSEATSRWSQALEGLEQ------------RSRPYLQDVQRYETYRWILGCVLCSAILL 438

  Fly   455 MLVPLLLLFGL----LIALFSPK--------VASWLLCAVLVALFILFSVGVILVLF--YLVHG- 504
            :::..||...|    |.|...|.        .|.:|:..  ||...||:..:||::|  :||.|
  Rat   439 VVICNLLGLSLGIWGLFAREDPSHSETKGEAGARFLMAG--VAFSFLFAAPLILLVFATFLVGGN 501

  Fly   505 --ALIYQAFCSRKFPQPVDNKSINPNKF-------LPENVTTFRSMPMVRTSEILQSCVRNESLY 560
              .|:.:::.|.:..:.||.....|...       |.:|::.|::         .:.|....:|:
  Rat   502 VQTLVCRSWESGELYEFVDTPGNLPPSMNLSYLLGLRKNISVFQA---------YRQCKAGTALW 557

  Fly   561 NVLGIKEIYDPYGFRDDVMIDVVKSLEKMGN--TSMPGAPKE---IHPDAEESAKKLLTGNLSTY 620
            .||.:.:.||.     |..:|:.:...|:..  .|.....|:   ::|.|.::.:.|.:..|...
  Rat   558 KVLQLNDSYDL-----DKHLDIKQYTHKLQQELQSFKVDLKDLDLLNPAARQNLEALQSSGLEKI 617

  Fly   621 DIKDYTKYICPQLVPEPNPGPLDGLTRKLESLA---NKVEPGVTLKNQAIHLRAYQKHLCVPLAA 682
            ..:|:...|...:|..    .:..|.::||.||   |:......|:.:|..||:..:...||...
  Rat   618 HYRDFLVQIQKPVVKT----DMGQLAKELEGLAQAHNESLRRQQLQEEARELRSLYQEKVVPQEN 678

  Fly   683 IVQRLIKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEVARNISKLVKSG-- 745
            :|.:|...::    :|.............|||.:.:    |:.:...:.:.:.||.::...:.
  Rat   679 LVAKLNPSIR----VLESSAPKLQVNTSDLLDIVAR----LKGELPAQLNHILRNATECFLTREM 735

  Fly   746 --LDDYVRVVEEATKEDMESCEPLIRE-DDEAMVEYADLCNRIAKPMNAIWFWLLLFSSLLLPTI 807
              ...||..|.|...:.:.:|:|..:. ||..|:    ||:.:|.|.||.||.|...:..|:|:|
  Rat   736 GYFSQYVTWVREEVTQHIATCQPFSKALDDGHMI----LCDMMANPWNAFWFCLGWCTFFLIPSI 796

  Fly   808 -----CCTHF--LRSRLNS 819
                 ...:|  :|.||:|
  Rat   797 IFAVKTSKYFRPIRKRLSS 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	None
Prom2	NP_620212.2	Prominin	27..807	CDD:398888	162/789 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354197
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46440
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22730
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960