Protein Alignment CG45067 and Prom1

DIOPT Version :10

• Sequence 1: NP_001334707.1
• Gene: CG45067 / 38371
• FlyBaseID: FBgn0266437
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_001157049.1
• Gene: Prom1 / 19126
• MGIID: 1100886
• Length: 867
• Species: Mus musculus
• Alignment Length: 864
• Identity: 185/864 - (21%)
• Similarity: 326/864 - (37%)
• Gaps: 192/864 - (22%)

  Fly    47 PQNRYAEPESRSNNGDADSMCPITYLSHVFTGSVVSYAKEVPKGYISKDGNDIGSKVQEDDWEAY 111
            |..:| |.:...|.|   .:.|:..:.|:|..  |....:.|...|.|       .:|..:::..
Mouse    37 PTTKY-ETQDTFNAG---IVGPLYKMVHIFLN--VVQPNDFPLDLIKK-------LIQNKNFDIS 88

  Fly   112 LASQK------GLKIL-----VLLLVLLFLLILILGLLYAC------CC--VAWEKNERSSRGC- 156
            :.|::      .|||.     ||:..:|.||.:||..|..|      ||  ...|.::|..:..
Mouse    89 VDSKEPEIIVLALKIALYEIGVLICAILGLLFIILMPLVGCFFCMCRCCNKCGGEMHQRQKQNAP 153

  Fly   157 --RYCCGILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKASERLR 219
              |.|.|:.|.::.|||.|.:|...:|..|....:|           .:|..|...|:.....|.
Mouse   154 CRRKCLGLSLLVICLLMSLGIIYGFVANQQTRTRIK-----------GTQKLAKSNFRDFQTLLT 207

  Fly   220 HL-----YVINYDQKVK----------------RIKSALNQDPSIKYPNRELEVHAKAIERLIEV 263
            ..     ||:......|                |||..|.  |.:.....|::..|.||::..:.
Mouse   208 ETPKQIDYVVEQYTNTKNKAFSDLDGIGSVLGGRIKDQLK--PKVTPVLEEIKAMATAIKQTKDA 270

  Fly   264 LRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVKRDLMVIL-IADCTHSECQDFYRANEIKML 327
            |:||          .:.|...:..|||....|..|:..:...| .:|||.........:....:.
Mouse   271 LQNM----------SSSLKSLQDAATQLNTNLSSVRNSIENSLSSSDCTSDPASKICDSIRPSLS 325

  Fly   328 DMG-CLHYDSLPEFEPLLESVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSVNKDLNKG 391
            .:| .|:...||..:..|.:|.||..:.......:....:..:.:.|:|:..|::..|...|:..
Mouse   326 SLGSSLNSSQLPSVDRELNTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTVDVIKDVKNTLDSI 390

  Fly   392 AKKLQERYEASLKVLRQVVEEMKKDMPLVVKTNPR--SRSTPAADLRRKLGSSWFGTTLCLIVLL 454
            :..:::..::.      .:|:|...:...:..:.|  ::..|..:   :..|.|:...|.:..||
Mouse   391 SSNIKDMSQSI------PIEDMLLQVSHYLNNSNRYLNQELPKLE---EYDSYWWLGGLIVCFLL 446

  Fly   455 MLVPLLLLFGLLIALF------SPKVASWLLCAVLV-ALFILFSVG---------VILVLFYLVH 503
            .|:......|||..:|      :|....   |.... .:|::..||         :|||:...|.
Mouse   447 TLIVTFFFLGLLCGVFGYDKHATPTRRG---CVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVV 508

  Fly   504 GALIYQAFCSRKFPQPVDNKS----INPNKFLPENVTTFRSMPMVRT-------SEILQSCVRNE 557
            ||.:.:..|     :|.:||.    ::....|.|....:.|..:...       .::.:.|.|..
Mouse   509 GANVEKLLC-----EPYENKKLLQVLDTPYLLKEQWQFYLSGMLFNNPDINMTFEQVYRDCKRGR 568

  Fly   558 SLY------NVLGIKEIYDPYGFRDDVMIDV------VKSLEKMGNTSMPGAPKEIHPDAEESAK 610
            .:|      ||:.:.:.::.....:::..::      :.|:|.:.||.........|
Mouse   569 GIYAAFQLENVVNVSDHFNIDQISENINTELENLNVNIDSIELLDNTGRKSLEDFAH-------- 625

  Fly   611 KLLTGNLSTYDIKDYTKYICPQLVPEPNPGPLDGLT--RKLESLANKVEPGVTLKNQAI----HL 669
                   |..|..||:.|:   ...|.:|..::.||  ..||:.||::..| .||...:    ::
Mouse   626 -------SGIDTIDYSTYL---KETEKSPTEVNLLTFASTLEAKANQLPEG-KLKQAFLLDVQNI 679

  Fly   670 RAYQKHLCVPLAAIVQRLIKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEV 734
            ||..:||..|    ||:.:..|:|..|.|.       :..:.|.:|:|:  .|...||.:..  :
Mouse   680 RAIHQHLLPP----VQQSLNTLRQSVWTLQ-------QTSNKLPEKVKK--ILASLDSVQHF--L 729

  Fly   735 ARNISKLV-----KSG------LDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADLCNRIAKP 788
            ..|:|.:|     |.|      .:.|:..|..|..|.|.||:|:....|.|:  ...||..:|.|
Mouse   730 TNNVSLIVIGETKKFGKTILGYFEHYLHWVFYAITEKMTSCKPMATAMDSAV--NGILCGYVADP 792

  Fly   789 MNAIWFWLLLFSSLLLPTI 807
            :|..||.:...:.||||.:
Mouse   793 LNLFWFGIGKATVLLLPAV 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	Prominin	<215..791	CDD:461660	133/656 (20%)
Prom1	NP_001157049.1	Prominin	19..822	CDD:461660	185/864 (21%)