DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45067 and Prom1

DIOPT Version :9

Sequence 1:	NP_001334707.1	Gene:	CG45067 / 38371	FlyBaseID:	FBgn0266437	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001157049.1	Gene:	Prom1 / 19126	MGIID:	1100886	Length:	867	Species:	Mus musculus

Alignment Length:	864	Identity:	185/864 - (21%)
Similarity:	326/864 - (37%)	Gaps:	192/864 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PQNRYAEPESRSNNGDADSMCPITYLSHVFTGSVVSYAKEVPKGYISKDGNDIGSKVQEDDWEAY 111
            |..:| |.:...|.|   .:.|:..:.|:|..  |....:.|...|.|       .:|..:::..
Mouse    37 PTTKY-ETQDTFNAG---IVGPLYKMVHIFLN--VVQPNDFPLDLIKK-------LIQNKNFDIS 88

  Fly   112 LASQK------GLKIL-----VLLLVLLFLLILILGLLYAC------CC--VAWEKNERSSRGC- 156
            :.|::      .|||.     ||:..:|.||.:||..|..|      ||  ...|.::|..:..
Mouse    89 VDSKEPEIIVLALKIALYEIGVLICAILGLLFIILMPLVGCFFCMCRCCNKCGGEMHQRQKQNAP 153

  Fly   157 --RYCCGILLAILALLMLLFLILAIMAATQLNINLKNLKASGCYPSNSSQSSADYIFQKASERLR 219
              |.|.|:.|.::.|||.|.:|...:|..|....:|           .:|..|...|:.....|.
Mouse   154 CRRKCLGLSLLVICLLMSLGIIYGFVANQQTRTRIK-----------GTQKLAKSNFRDFQTLLT 207

  Fly   220 HL-----YVINYDQKVK----------------RIKSALNQDPSIKYPNRELEVHAKAIERLIEV 263
            ..     ||:......|                |||..|.  |.:.....|::..|.||::..:.
Mouse   208 ETPKQIDYVVEQYTNTKNKAFSDLDGIGSVLGGRIKDQLK--PKVTPVLEEIKAMATAIKQTKDA 270

  Fly   264 LRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVKRDLMVIL-IADCTHSECQDFYRANEIKML 327
            |:||          .:.|...:..|||....|..|:..:...| .:|||.........:....:.
Mouse   271 LQNM----------SSSLKSLQDAATQLNTNLSSVRNSIENSLSSSDCTSDPASKICDSIRPSLS 325

  Fly   328 DMG-CLHYDSLPEFEPLLESVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSVNKDLNKG 391
            .:| .|:...||..:..|.:|.||..:.......:....:..:.:.|:|:..|::..|...|:..
Mouse   326 SLGSSLNSSQLPSVDRELNTVTEVDKTDLESLVKRGYTTIDEIPNTIQNQTVDVIKDVKNTLDSI 390

  Fly   392 AKKLQERYEASLKVLRQVVEEMKKDMPLVVKTNPR--SRSTPAADLRRKLGSSWFGTTLCLIVLL 454
            :..:::..::.      .:|:|...:...:..:.|  ::..|..:   :..|.|:...|.:..||
Mouse   391 SSNIKDMSQSI------PIEDMLLQVSHYLNNSNRYLNQELPKLE---EYDSYWWLGGLIVCFLL 446

  Fly   455 MLVPLLLLFGLLIALF------SPKVASWLLCAVLV-ALFILFSVG---------VILVLFYLVH 503
            .|:......|||..:|      :|....   |.... .:|::..||         :|||:...|.
Mouse   447 TLIVTFFFLGLLCGVFGYDKHATPTRRG---CVSNTGGIFLMAGVGFGFLFCWILMILVVLTFVV 508

  Fly   504 GALIYQAFCSRKFPQPVDNKS----INPNKFLPENVTTFRSMPMVRT-------SEILQSCVRNE 557
            ||.:.:..|     :|.:||.    ::....|.|....:.|..:...       .::.:.|.|..
Mouse   509 GANVEKLLC-----EPYENKKLLQVLDTPYLLKEQWQFYLSGMLFNNPDINMTFEQVYRDCKRGR 568

  Fly   558 SLY------NVLGIKEIYDPYGFRDDVMIDV------VKSLEKMGNTSMPGAPKEIHPDAEESAK 610
            .:|      ||:.:.:.::.....:::..::      :.|:|.:.||.........|
Mouse   569 GIYAAFQLENVVNVSDHFNIDQISENINTELENLNVNIDSIELLDNTGRKSLEDFAH-------- 625

  Fly   611 KLLTGNLSTYDIKDYTKYICPQLVPEPNPGPLDGLT--RKLESLANKVEPGVTLKNQAI----HL 669
                   |..|..||:.|:   ...|.:|..::.||  ..||:.||::..| .||...:    ::
Mouse   626 -------SGIDTIDYSTYL---KETEKSPTEVNLLTFASTLEAKANQLPEG-KLKQAFLLDVQNI 679

  Fly   670 RAYQKHLCVPLAAIVQRLIKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEV 734
            ||..:||..|    ||:.:..|:|..|.|.       :..:.|.:|:|:  .|...||.:..  :
Mouse   680 RAIHQHLLPP----VQQSLNTLRQSVWTLQ-------QTSNKLPEKVKK--ILASLDSVQHF--L 729

  Fly   735 ARNISKLV-----KSG------LDDYVRVVEEATKEDMESCEPLIREDDEAMVEYADLCNRIAKP 788
            ..|:|.:|     |.|      .:.|:..|..|..|.|.||:|:....|.|:  ...||..:|.|
Mouse   730 TNNVSLIVIGETKKFGKTILGYFEHYLHWVFYAITEKMTSCKPMATAMDSAV--NGILCGYVADP 792

  Fly   789 MNAIWFWLLLFSSLLLPTI 807
            :|..||.:...:.||||.:
Mouse   793 LNLFWFGIGKATVLLLPAV 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	None
Prom1	NP_001157049.1	Prominin	19..822	CDD:368462	185/864 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850503
Domainoid	1	1.000	129	1.000	Domainoid score	I5224
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4594
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46440
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22730
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.010