Protein Alignment CG45067 and PROM2

DIOPT Version :9

• Sequence 1: NP_001334707.1
• Gene: CG45067 / 38371
• FlyBaseID: FBgn0266437
• Length: 881
• Species: Drosophila melanogaster
• Sequence 2: NP_001159449.1
• Gene: PROM2 / 150696
• HGNCID: 20685
• Length: 834
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 167/845 - (19%)
• Similarity: 316/845 - (37%)
• Gaps: 205/845 - (24%)

  Fly    79 SVVS---YAKEVPKGYISKDGNDIGS-KVQEDDWEAYLASQKGLKILVLLLVLLFLLILILGLLY 139
            |||.   :..|:.|..:    |::.| ||.|     .:..:.|..:..::..|..||:...||.:
Human    72 SVVQLNPFPSELVKALL----NELASVKVNE-----VVRYEAGYVVCAVIAGLYLLLVPTAGLCF 127

  Fly   140 ACC-----CVAWEKNERSSRGC-RYCCGILLAILALLMLLFLILA--------------IMAATQ 184
            .||     |....|.|..:..| |....:.|.:..||:|:.::.|              |.|..:
Human   128 CCCRCHRRCGGRVKTEHKALACERAALMVFLLLTTLLLLIGVVCAFVTNQRTHEQMGPSIEAMPE 192

  Fly   185 LNINLKNLKASGCYPSNSSQSSADYIF--QKASERLRHLYVINYDQKVKRIKSALN-QDPSIKYP 246
            ..::|..|.:.  .|......:..:..  ::.||.|..:.|        .|.||:: |..|..||
Human   193 TLLSLWGLVSD--VPQELQAVAQQFSLPQEQVSEELDGVGV--------SIGSAIHTQLRSSVYP 247

  Fly   247 --------NRELEVHAKAIERL----IEVLRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVK 299
                    .:.|:|....::.|    :|:....:.::|.:...::|||:..:.|     ..:|
Human   248 LLAAVGSLGQVLQVSVHHLQTLNATVVELQAGQQDLEPAIREHRDRLLELLQEA-----RCQG-- 305

  Fly   300 RDLMVILIADCTHSECQDFYRANEIKMLDMGCLHYDSLPEFEPLLESVQEVIDSKFIDYPLQAVG 364
                     ||..:       .:..:.|::|. .:..:|..:.:|..::.|.::.|.....:...
Human   306 ---------DCAGA-------LSWARTLELGA-DFSQVPSVDHVLHQLKGVPEANFSSMVQEENS 353

  Fly   365 QLRRMSSAIKNRMSDILDSVNKDL---NKGAKKLQERY---EASLKVLRQVVEEMKKDMPLVVKT 423
            ....:.:....:.|.::..:.|.:   .:|.:.|.|.:   ||:.:..:.:.|..:...|.:
Human   354 TFNALPALAAMQTSSVVQELKKAVAQQPEGVRTLAEGFPGLEAASRWAQALQEVEESSRPYL--- 415

  Fly   424 NPRSRSTPAADLRRKLGSSWF-GTTLCLIVLLMLVPLLLLFGLLIALFS---------PKV---- 474
                     .:::|.....|. |..||.:||  .|.|..|.||.:.::.         |:.
Human   416 ---------QEVQRYETYRWIVGCVLCSVVL--FVVLCNLLGLNLGIWGLSARDDPSHPEAKGEA 469

  Fly   475 -ASWLLCAVLVALFILFSVGVILVLF--YLVHG---ALIYQAFCSRKFPQPVDNKSINPNKFLPE 533
             |.:|:..  |.|..||:..:||::|  :||.|   .|:.|::         :|..:......|.
Human   470 GARFLMAG--VGLSFLFAAPLILLVFATFLVGGNVQTLVCQSW---------ENGELFEFADTPG 523

  Fly   534 NVTTFRSMPMVRTSEIL------------QSCVRNESLYNVLGIKEIYDPYGFRD---------- 576
            |:.     |.:..|::|            |.|....:|:.||.:.:.||.....|
Human   524 NLP-----PSMNLSQLLGLRKNISIHQAYQQCKEGAALWTVLQLNDSYDLEEHLDINQYTNKLRQ 583

  Fly   577 ---DVMIDVVKSLEKMGNTSMPGAPKEIHPDAEESAKKLLTGNLSTYDIKDYTKYICPQLVPEPN 638
               .:.:| .:||:.:.:.            |....:.|.:..|......|:...|...:|..
Human   584 ELQSLKVD-TQSLDLLSSA------------ARRDLEALQSSGLQRIHYPDFLVQIQRPVVKT-- 633

  Fly   639 PGPLDGLTRKLESLANKVEP---GVTLKNQAIHLRAYQKHLCVPLAAIVQRLIKRLKQMDWLLSG 700
              .::.|.::|:.||...:.   |..|:.:|..||...:...||..::|.:|...::.::
Human   634 --SMEQLAQELQGLAQAQDNSVLGQRLQEEAQGLRNLHQEKVVPQQSLVAKLNLSVRALE----- 691

  Fly   701 GYGSFVKYLHHLLDKIKQGDDLLRQDSKKEADEVARNISKLVKSG----LDDYVRVVEEATKEDM 761
               |....|......:......|:.:....|..:.||:|:...:.    ...||..|.|...:.:
Human   692 ---SSAPNLQLETSDVLANVTYLKGELPAWAARILRNVSECFLAREMGYFSQYVAWVREEVTQRI 753

  Fly   762 ESCEPLIREDDEAMVEYADLCNRIAKPMNAIWFWLLLFSSLLLPTI-----CCTHF--LRSRLNS 819
            .:|:||....|.:.|   .||:.:|.|.||.||.|...:..|:|:|     ...:|  :|.||:|
Human   754 ATCQPLSGALDNSRV---ILCDMMADPWNAFWFCLAWCTFFLIPSIIFAVKTSKYFRPIRKRLSS 815

  Fly   820  819
            Human   816  815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	None
PROM2	NP_001159449.1	Prominin	25..807	CDD:283200	162/835 (19%)
		HrpJ	531..681	CDD:301626	30/166 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46440
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22730
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.050