DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45067 and prom2

DIOPT Version :9

Sequence 1:	NP_001334707.1	Gene:	CG45067 / 38371	FlyBaseID:	FBgn0266437	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001243221.1	Gene:	prom2 / 100485371	XenbaseID:	XB-GENE-853506	Length:	788	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	157/820 - (19%)
Similarity:	301/820 - (36%)	Gaps:	223/820 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 GLKILVLLLVLLFLLILILGLLYACCCVAWEKNERSSRGCR--YCCGILLAILALLMLLFLILAI 179
            |.....::.:|..:.:|:.|::|   ||...:.||..:.|.  :|..:.:.:|..|....|:..:
Frog    54 GYVACAVIAILFLIFMLVFGIIY---CVFQCRGERIFKRCEGMFCHRVPVFLLLFLTCTVLLAGV 115

  Fly   180 MAATQLNINLKNLKASGCYPSNSS----QSSADYIFQKASERLRHLYVINYDQKVKRIKSALNQD 240
            :....||..::...|.|.|....|    :||.|                |....:::|.|    |
Frog   116 ICTFCLNQKVQEEFAPGVYEVTDSLQRFRSSID----------------NLPLVLEKISS----D 160

  Fly   241 PSIKYPNR----ELEVHAKAIERLIEVLRNMRRIKPVMLRIKNRLLDARRLATQFRDALRGVKRD 301
            .||  |.:    ||:.....|.|.:....| :.|.|:       |.|:.:.|.|.::|.:.|. |
Frog   161 FSI--PKQKVLDELQSFGPDINRTLSAKLN-QEIYPL-------LQDSYQTAKQLKEAAQAVV-D 214

  Fly   302 LMVI----------LIAD-----------CTHSECQDFYRANEIKMLDMGCLHYDSLPEFEPLLE 345
            :.|.          |:|:           .:.::|::...|..|........:|..:|..:..::
Frog   215 VNVAVKLLQKSQSKLVAELSSHRQNLERTLSDTQCKECKEAAAIVPQLQQTANYSQIPSLDDYVK 279

  Fly   346 SVQEVIDSKFIDYPLQAVGQLRRMSSAIKNRMSDILDSVNKDLNKGAKKLQERYEASLKVLRQVV 410
            .:.:|.........||.:.....|...:              :.:.:|.:.|..:| |..:...:
Frog   280 KLTQVRKINLTGIFLQGIRLFNEMPQFV--------------ITQASKSISETKKA-LDTIEGKI 329

  Fly   411 EEMKKDMPLVVKTNPRSRSTPAADLRRKLGSS---------W-FGTTLCLIVLLMLVPLLLLFGL 465
            ..:...:|:...|.|..::...|:.:..:...         | .|.|||.:  |:|:.:....||
Frog   330 NSLISSVPIQQYTEPIHKALLEAEEKSAVYGKEAERYEYYRWVIGITLCCV--LLLITICTFLGL 392

  Fly   466 LIALF-----------SPKVASWLLCAVLVALFILFS-VGVILVLFYLVHGALIYQAFCSRKFPQ 518
            |:.::           :.:...:||....|.:...|| :.:|||....:.|..:....|     :
Frog   393 LLGVWYLYLQQDGVSSNLRQTGYLLLKGEVYVSFCFSWLLIILVYVTFLVGGNVQTLLC-----E 452

  Fly   519 PVDNKSI-----NPNKFLPENVTTFRSMPM---VRTSEILQSCVRNESLYNVLGIKEIYDPYGFR 575
            |..|..|     :||. ||.:|:....:.:   |..|.:.|.|.....:::||   ::.||.|..
Frog   453 PWANGEIYSFLDDPNN-LPPSVSLSNRLGLREDVNISYMYQLCKEGAPIWDVL---QVDDPTGML 513

  Fly   576 DDVMID--------------------------VVKSLEKMGNTSMPGAP-----KEIHPDAEESA 609
            ..:.|.                          .:|:|.:..::.:...|     .:|.|.
Frog   514 QSINITQYTAEIQNKVNNFTVDLSGLTIMTIIAIKTLYEYSHSGIEKVPYDAMLAQIQPP----- 573

  Fly   610 KKLLTGNLSTYDIKDYTKYICPQLVPEPNPGPLDGLTRKLESLANK---VEPGVTLKNQAIH--- 668
                   |.|.|:......:......:.|    |.:..:|::.||.   ::.| |::.|.:|
Frog   574 -------LVTLDLGHLASMLKSLATVQNN----DTIRTQLQNEANALGGIQNG-TVREQNVHLSK 626

  Fly   669 ----LRAYQKHLCVP-LAAIVQRLIKRLKQMDWLLSGGYGSFVKYLHHLLDKIKQGDDLLRQDSK 728
                |.:..:||  | :.|.:...|:.::.:...|.||              |.|   ||:.:|
Frog   627 LNDSLHSLAEHL--PNMQANINHTIENIRSLQDTLIGG--------------IIQ---LLKNES- 671

  Fly   729 KEADEVARNISKLVKSGLDDYVRVVEEATK---EDMESCEPLIREDDEAMVEYADLCNRIAKPMN 790
                      :.|::..:..:.:.::..||   ||:.||:.:.|..|..   :..:|:.|..|.|
Frog   672 ----------TCLLRKAIAHFTQYLDWVTKLITEDVSSCQSVPRTLDNI---HTVVCDNITNPWN 723

  Fly   791 AIWFWLLLFSSLLLPTICCTHFLRSRLNSLKH-SVATPVS 829
            ..||.|...:..|:|.|..:      :.|::| |:..|:|
Frog   724 GFWFCLAWCTFFLIPNILLS------IKSVEHFSLLKPIS 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45067	NP_001334707.1	None
prom2	NP_001243221.1	Prominin	38..745	CDD:368462	152/806 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5091
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1129032at2759
OrthoFinder	1	1.000	-	-		FOG0002387
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22730
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.110