DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cht7 and Cht5

DIOPT Version :9

Sequence 1:	NP_647768.3	Gene:	Cht7 / 38370	FlyBaseID:	FBgn0035398	Length:	1013	Species:	Drosophila melanogaster
Sequence 2:	NP_650314.1	Gene:	Cht5 / 41687	FlyBaseID:	FBgn0038180	Length:	595	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	181/536 - (33%)
Similarity:	267/536 - (49%)	Gaps:	84/536 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 TKVDDGTPKIVCYYTNWSQYRVKIGKFVPEDIPADLCTHIIFAFGWLKKNKLSSYESNDETKDNV 180
            |...|...:||||::||:.||..||::..||:|||||||||::|          ...||::.|.:
  Fly    20 TVASDQASRIVCYFSNWAVYRTGIGRYGLEDVPADLCTHIIYSF----------IGVNDKSWDVL 74

  Fly   181 ---------PGLYERMMTLKKANPKLKILLALGGWSFGTQKFKDMSSTRYTRQTFVYSAIPFLRK 236
                     .|.:.:...|||:||.:|:.:|:|||:.|..|:..|.:.|..||:|:.|.:.|:::
  Fly    75 VIDPELDVDQGGFSKFTQLKKSNPNVKLEIAVGGWAEGGSKYSQMVAVRDRRQSFIRSVVRFMKQ 139

  Fly   237 RGFDGLDMDWEYPKGSD------DKKNFVLLLKELREAFEAEAQELKKPRLLLSAAVPVGPDNIR 295
            ..|||.|:|||||..:|      ||..|:..::|||.||:.|.:..:     ::.||||....:.
  Fly   140 YNFDGFDLDWEYPGATDRGGNYGDKDKFLYFVEELRRAFDREGRGWE-----ITMAVPVAKFRLN 199

  Fly   296 GGYDVPAIASYLDFINLMAYDFHGKWERETGHNAPLYAPSTDSEWRKQLSVDNAASLWVKMGAPK 360
            .||.||.:...||.|:.|.||..|.|......::|||....|....::|:|::..:||.:||.|.
  Fly   200 EGYHVPELCEALDAIHAMTYDLRGNWAGFADVHSPLYKRKHDQYAYEKLNVNDGLALWEEMGCPA 264

  Fly   361 EKLVIGMPTYGRSFTLANPDKH---GP--NAPASGGGREGVYTKEGGFLAYYEICEMLLN---GA 417
            .|||:|:|.|||:|||:|.:|:   |.  |..| |||..|.||...|||||||||..:::   |.
  Fly   265 NKLVVGVPFYGRTFTLSNSNKNYNMGTYINKEA-GGGAPGPYTNASGFLAYYEICTEVMDKSKGW 328

  Fly   418 VYVWDDEMKVPYLVDGDQWVGFDDERAIRNKMHWIKSNGFGGAMVWTIDMDDFKGEVCG--GNVK 480
            ...|||...|||.....||||:::|.:|:.||.:||..|:.|||.|.||||||.| :||  ..:.
  Fly   329 TVEWDDAGMVPYTYKDTQWVGYENEASIQIKMDFIKQRGYAGAMTWAIDMDDFHG-MCGRKNGLT 392

  Fly   481 YPLIGAMREELLGISRGKEAKDVNWTAVAATFEDIEE--------------KPEPIKIS------ 525
            ..|...|:...:.....:......|....||..:.:|              ||:|...|
  Fly   393 QILYDNMKNYRVPEPTRQTTPRPEWAKPPATPPNPDEGAVVAPTTSTTKRPKPKPKPTSSPLSPT 457

  Fly   526 -----VDEILNKVRKPQVQKKQRIKSGANAVASNTRPA--------QVFCY----LTSWSAKRPG 573
                 |..:.:...||..:|.::.|.  ....:.|.||        :...|    :.....::|.
  Fly   458 SAPGPVPTVGSSTPKPTTKKPKKPKK--TTTTTTTTPAPEKSTEEPEEVVYPVDPVEPTDPEQPM 520

  Fly   574 AGKFQPENIDPKLCTH 589
            ..:|.|..||   ||:
  Fly   521 GPQFDPNEID---CTN 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht7	NP_647768.3	Glyco_18	124..468	CDD:214753	146/366 (40%)
		GH18_chitolectin_chitotriosidase	125..491	CDD:119351	155/390 (40%)
		Glyco_18	559..898	CDD:214753	8/35 (23%)
		GH18_chitolectin_chitotriosidase	560..919	CDD:119351	8/34 (24%)
		CBM_14	951..1005	CDD:279884
Cht5	NP_650314.1	Glyco_18	28..379	CDD:214753	146/366 (40%)
		GH18_chitolectin_chitotriosidase	29..397	CDD:119351	154/384 (40%)
		Trypan_PARP	367..469	CDD:114603	25/102 (25%)
		CBM_14	531..578	CDD:279884	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	1	1.000	-	-		mtm1002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
	8	7.920